A5066971246- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Innovation and Knowledge Management
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Innovation Policy and R&D
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Connective tissue disorders research
- Cancer Immunotherapy and Biomarkers
- Firm Innovation and Growth
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- Galectins and Cancer Biology
- Cell death mechanisms and regulation
Kyungpook National University
2016-2025
Sanford Burnham Prebys Medical Discovery Institute
2007-2023
Convergence
2023
Institute for Medical Research
2007-2023
Kwangwoon University
2011-2019
Daewoong Pharmaceutical (South Korea)
2016
Kyungil University
2012
Korea Institute of Science and Technology
2010-2012
Korea National Institute of Health
2012
Kyungpook National University Hospital
2010
Abstract Inhibitors of the secretion cancer exosomes, which promote progression and metastasis, may not only accelerate exosome biology research but also offer therapeutic benefits for patients. Here we identify sulfisoxazole (SFX) as an inhibitor small extracellular vesicles (sEV) from breast cells through interference with endothelin receptor A (ETA). SFX, FDA-approved oral antibiotic, showed significant anti-tumor anti-metastatic effects in mouse models xenografts, reduced expression...
βig-h3 is a transforming growth factor-β-inducible cell adhesion molecule that has four characteristic homologous repeated domains. We made recombinant proteins, which were highly active in mediating human corneal epithelial (HCE) and spreading. The 2nd the 4th domains sufficient to mediate HCE adhesion. A sequence analysis showed aspartic acid (Asp) isoleucine (Ile) of are conserved many fasciclin 1 (fas-1) Substitution mutational study identified these two amino acids essential for...
Herein, we prepared tumor-targeting peptide (AP peptide; CRKRLDRN) conjugated pH-responsive polymeric micelles (pH-PMs) in cancer therapy by active and tumor targeting delivery systems, simultaneously. The tumoral were mixing AP PEG-poly(d,l-lactic acid) block copolymer (AP-PEG-PLA) into the of methyl ether poly(ethylene glycol) (MPEG)-poly(β-amino ester) (PAE) (MPEG-PAE). These mixed amphiphilic copolymers self-assembled to form stable peptide-conjugated AP-PEG-PLA/MPEG-PAE (AP-pH-PMs) with...
Bone formation involves several tightly regulated gene expression patterns of bone-related proteins. To determine the proteins during MC3T3-E1 osteoblast-like cell differentiation, we used Northern blotting, enzymatic assay, and histochemistry. We found that were in a temporal manner successive developmental stages including proliferation (days 4-10), bone matrix formation/maturation 10-16), mineralization 16-30). During period cell-cycle related genes such as histone H3 H4, ribosomal...
Bone formation involves several tightly regulated gene expression patterns of bone-related proteins. To determine the proteins during MC3T3-E1 osteoblast-like cell differentiation, we used Northern blotting, enzymatic assay, and histochemistry. We found that were in a temporal manner successive developmental stages including proliferation (days 4–10), bone matrix formation/maturation 10–16), mineralization 16 –30). During period cell-cycle related genes such as histone H3 H4, ribosomal...
// Jong-Lyel Roh 1 , Eun Hye Kim Jin Young Park Ji Won Minsu Kwon and Byung-Heon Lee 2 Department of Otolaryngology, Asan Medical Center, University Ulsan College Medicine, Seoul, Republic Korea Biochemistry Cell Biology, School Kyungpook National University, Daegu, Correspondence: Roh, email: Keywords : piperlongumine, reactive oxygen species, head neck cancer, cisplatin, cell death Received June 06, 2014 Accepted August 26, Published 27, Abstract Adaptation to cellular stress is not a...
Significance Expression and function of odorant receptors (ORs) are being increasingly reported in nonolfactory sites. However, ORs that can be targeted by drugs to treat diseases remain poorly identified. Here, we hypothesized the macrophage OR Olfr78 functions as a tumor-derived lactate sensor shapes macrophage–tumor axis. G protein–coupled receptor Gpr132 form heterodimer senses tumor microenvironment, leading generation tumor-associated macrophages with protumoral M2 phenotype, which...
βig-h3 is a TGF-β-induced matrix protein known to mediate the adhesion of several cell types. In this study, we found that all four fas-1 domains in MRC-5 fibroblast and was specifically inhibited by function-blocking monoclonal antibody specific for αvβ5 integrin. Using deletion mutants fourth domain revealed motif (denoted YH motif) located amino acids 548–614. Experiments with substitution showed tyrosine 571, histidine 572, their flanking leucine isoleucine acids, which are highly...
Protein-cage nanoparticles are promising multifunctional platforms for targeted delivery of imaging and therapeutic agents owing to their biocompatibility, biodegradability, low toxicity. The major advantage protein-cage is the ability decorate surfaces with multiple functionalities through genetic chemical modification achieve desired properties and/or diagnostic purposes. Specific peptides identified by phage display can be genetically fused onto surface cage proteins promote association a...
Nab-paclitaxel (Abx) is widely employed in malignant tumor therapy. In cells and pro-tumoral M2-type macrophages, the IL4 receptor (IL4R) upregulated. This study aimed to elucidate selective delivery of Abx macrophages by targeting IL4R reprogramming them into an anti-tumoral M1-type.
betaig-h3 is an extracellular matrix protein that mediates adhesion and migration of several cell types through interaction with integrins. In the present study, we tested whether endothelial migration, thereby regulating angiogenesis. this demonstrate not only itself but also all four fas-1 domains mediate alphavbeta3 integrin. We found integrin-interacting motif same YH reported previously to interact alphavbeta5 The peptide inhibited in a dose-dependent manner. has anti-angiogenic...
Abstract Bladder cancer is one of the most common tumors genitourinary tract. Here, we use phage display to identify a peptide that targets bladder tumor cells. A library containing random peptides was screened for binding cells from human xenografts. Phage clones were further selected cell line in culture. Six displaying consensus sequence CXNXDXRX/RC showed selective primary tissue. Of these, CSNRDARRC study as synthetic peptide. Fluorescein-conjugated selectively bound frozen sections...
Targeted delivery of imaging agents and therapeutics to tumors would provide early detection increased therapeutic efficacy against cancer. Here we have screened a phage-displayed peptide library identify peptides that selectively bind lung tumor cells. Evaluation individual phage clones after screening revealed clone displaying the CSNIDARAC bound H460 cells at higher extent than other clones. The synthetic strongly was efficiently internalized into cells, while little binding control seen....