A5101558960- Allelopathy and phytotoxic interactions
- Phytochemistry and Biological Activities
- Weed Control and Herbicide Applications
- Plant Parasitism and Resistance
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Chemical synthesis and alkaloids
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Analysis
- Anesthesia and Neurotoxicity Research
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Photodynamic Therapy Research Studies
- Healthcare and Venom Research
- Nanoparticles: synthesis and applications
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Soft Robotics and Applications
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactivity Studies
Changzhi Medical College
2025
Chengdu University of Traditional Chinese Medicine
2023-2025
Chinese PLA General Hospital
2022-2025
Second People's Hospital of Yunnan Province
2024
Yunnan University
2024
Chinese Academy of Sciences
2015-2023
Kunming Institute of Botany
2019-2023
Guiyang Medical University
2023
Nanjing Tech University
2022
Soochow University
2019-2021
Targeted delivery of imaging agents and therapeutics to tumors would provide early detection increased therapeutic efficacy against cancer. Here we have screened a phage-displayed peptide library identify peptides that selectively bind lung tumor cells. Evaluation individual phage clones after screening revealed clone displaying the CSNIDARAC bound H460 cells at higher extent than other clones. The synthetic strongly was efficiently internalized into cells, while little binding control seen....
Autotoxicity, defined as a deleterious allelopathic effect among individuals of the same plant species, is considered one factors that contributes to replant failure. Tobacco, an important cultured and economic crop over world, has been often hampered by In view seriousness this problem, allelochemicals flue-cured tobacco their effects were investigated. The extracts rhizosphere soil exhibited phytotoxic activities against Lactuca sativa autotoxic itself. Bioassay-guided fractionation...
Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit activity α-glucosidase with an IC50 value 21.0 μg/mL. Bioactivity-guided isolation afforded two new compounds (1 2), together 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D 2D NMR, MS, IR UV). Compounds 1-17 21-25 evaluated for their inhibitory activities. Compound 11...
Four new phenolic compounds, hemerodiphenylethanes A-D (1-4), along with eight known compounds methyl 2,4-dihydroxy-6-[2-(4-hydroxyphenyl) ethyl] benzoate (5), 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (6), neochlorogenic acid (7), isoquercetin (8), isorhamnetin-3-O-β-D-galactoside (9), velutin (10), rutin (11), and (+)-syringaresinol (12), were isolated from the stems leaves of Hemerocallis citrina Baroni (Daylily). Their structures elucidated based on HR-ESI-MS, 1D- 2D-NMR...
Wound dressing diligently facilitate healing by fostering hemostasis, immunoregulation, the angiogenesis, and collagen deposition. Our methodology entails fabricating chitosan-taurine nanoparticles (CS-Tau) through an ionic gelation method. The morphology of CS-Tau was observed utilizing Transmission electron microscopy (TEM), scanning (SEM) Dynamic Light Scattering (DLS). are subsequently incorporated into carboxymethyl chitosan hydrogels for crosslinking EDC-NHS, yielding hydrogel...
Astragalus hoantchy, a widely cultivated medicinal plant species in traditional Chinese and Mongolian medicine, has been often hampered by replant failure during cultivation, like many other herbs of the genus Astragalus. Root aqueous extracts were reported to exhibit allelopathic activity against plants autotoxic on their own seedlings, but allelochemicals released have not specified so far. Ten compounds isolated from rhizosphere soil extract A. hoantchy elucidated spectroscopic analysis....
Helicobacter pylori (Hp) is a primary risk factor for gastric cancer. The fat mass and obesity-associated (FTO) gene associated with the development progression of various cancer types such as glioma, leukemia, breast colorectal aim present study was to investigate effect Hp infection on expression FTO its roles in It found that levels both mRNA protein were significantly increased Hp-infected human mucosal epithelial cells Mongolian gerbil tissues. tissues higher than para-cancer Data from...
Nf-E2-related transcription factor 2 (Nrf2) helps cells fight oxidative stress events in vivo and vitro by promoting the expression of antioxidants detoxification enzymes. The necessary factors regulating Nrf2 activity stability during analgesic nephropathy are not fully understood. Our results suggest that acetaminophen produces nephrotoxicity HK-2 inhibiting keap1 degradation. APAP subsided nuclear accumulation inhibition degradation, thereby reducing binding to ARE, leading loss...
This study measured the effect of Sika deer (Cervus nippon Temminck) antler protein (SDAPR), glycoproteins (SDAG), and polysaccharides (SDAPO) on cisplatin-induced cytotoxicity in HEK 293 cells, investigated SDAPR against nephrotoxicity mice.Cell viability was by MTT assay. ICR mice were randomly divided into five groups: control, cisplatin with vehicle, at three concentrations: 5, 10, or 20 mg/kg, p.o., 10 d. Cisplatin injected 7th day (25 i.p.). Renal function, oxidative stress, levels...
A strain SMrs28 was isolated from the rhizosphere soil of a toxic plant Stellera chamaejasme and identified as Bacillus sp. on basis morphological partial 16S rRNA gene sequence analysis. The crude extract fermentation broth showed strong nematocidal activities in preliminary test. To define active metabolites SMrs28, novel compound ( 1 ), 4‐oxabicyclo[3.2.2]nona‐1(7), 5,8‐triene, along with five known compounds 2 – 6 were by various column chromatographic techniques characterized...
Sevoflurane is a new type of inhalation anesthetic used widely in the clinic. It has characteristics rapid induction, recovery, and less irritative to airway. Studies have shown that sevoflurane can affect invasion migration variety malignant tumors. However, its effects on human glioma cells related mechanisms are not clear. Cultured U251 U87 were pretreated with sevoflurane. The effect proliferation was evaluated by MTT, cell assay, apoptosis, ability wound-healing Transwell assays....