A5057097309- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Phytochemistry and Biological Activities
- MicroRNA in disease regulation
- Molecular Sensors and Ion Detection
- Sesquiterpenes and Asteraceae Studies
- Crystallography and molecular interactions
- Circular RNAs in diseases
- Microbial Natural Products and Biosynthesis
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Redox biology and oxidative stress
- Pharmacological Effects of Natural Compounds
- Synthesis of Organic Compounds
- Luminescence and Fluorescent Materials
- Traditional Chinese Medicine Analysis
- Catalytic C–H Functionalization Methods
- Synthesis of Indole Derivatives
- Biological Activity of Diterpenoids and Biflavonoids
- Genomics, phytochemicals, and oxidative stress
- Thyroid Cancer Diagnosis and Treatment
- Oxidative Organic Chemistry Reactions
- Plant Toxicity and Pharmacological Properties
Gansu University of Traditional Chinese Medicine
2019-2025
Ministry of Education of the People's Republic of China
2024
Nanchang University
2024
Renji Hospital
2000-2020
Lanzhou City University
2016-2020
Shanghai Jiao Tong University
2017
Lanzhou University
2011-2016
State Council of the People's Republic of China
2016
State Key Laboratory of Applied Organic Chemistry
2012-2014
Beijing Forestry University
2011
Trichalcogenasumanenes were synthesized on a multigram scale through two-step approach that takes advantage of non-pyrolytic cyclization and solventless ring contraction. Solid-state structure photophysical investigations demonstrate these compounds are promising candidates for electronic materials.
The well-known 8-aminoquinoline framework offers an ideal model for the development of fluorescence-enhanced chemosensors through simple and convenient syntheses. Herein, a novel molecule chemosensor, 5-diethylamino-2-(quinolin-8-yliminomethyl)-phenol (HL), has been designed by combining moiety 4-(diethylamino)salicylaldehyde in single to prove selectivity sensitivity Mg2+, Zn2+, Co2+ dual-channel mode (fluorescence emission UV/Vis). When binding HL not only showed obvious fluorescence...
Traditional Chinese medicine (TCM) has been extensively employed for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). However, there is demand discovering more SARS-CoV-2 Mpro inhibitors with diverse scaffolds to optimize anti-SARS-CoV-2 lead compounds. In this study, comprehensive in silico and vitro assays were utilized determine potential from TCM compounds against Mpro, which an important therapeutic target SARS-CoV-2. The...
The rapid emergence of cross-resistance to the integrase strand transfer inhibitors (INSTIs) has become a serious problem in therapy human immunodeficiency virus type 1 (HIV-1) infection. Understanding detailed molecular mechanism INSTIs is therefore critical for development new effective against cross-resistance. On basis homology modeling constructed structure tetrameric HIV-1 intasome, mutation E138K/Q148K three important (Raltegravir (RAL, FDA approved 2007), Elvitegravir (EVG, 2012),...
Recent advances in nanotechnologies have led to wide use of nanomaterials biomedical field. However, nanoparticles are found interfere with protein misfolding and aggregation associated many human diseases. It is still a controversial issue whether inhibit or promote aggregation. In this study, we used molecular dynamics simulations explore the effects three kinds carbon including graphene, nanotube C₆₀ on behavior islet amyloid polypeptide fragment 22-28 (IAPP₂₂₋₂₈). The diverse behaviors...
Fusarium, a large genus of filamentous fungi, is widely distributed in soil and plants. Fusarium prolific source novel chemical constituents with various bioactivities. In search for antibiotics from endophytic the secondary metabolites avenaceum SF-1502 proliferatum AF-04 were investigated. An alkaloid (1), depsipeptide (6), five sesquiterpenoids (7–11) isolated extracts fungus F. SF-1502. Three alkaloids (2–4), (5), three (9, 11, 12), sesterterpene (13), four 1,4-naphthoquinones (14–17)...
Background: PARP1 (poly ADP-ribose polymerase 1, also known as ADPRT1) plays a significant role in DNA repair and has become an attractive target for treating PARP1-related diseases, such cancer. Objective: This study aimed to discover inhibitors targeting from the phytochemicals of Huangbai (Phellodendron chinense Schneid.), Baixianpi (Dictamnus dasycarpus Turcz.), Shechuangzi (Cnidium monnieri (L.) Spreng.). Methods: The chemical compositions Huangbai, Baixianpi, were extracted HERB...
Caffeic acid (CA) is a prevalent polyphenolic compound commonly found in various plant-derived foods. Due to its diverse pharmacological properties, including antioxidant activity, cardiovascular protection, and immune regulation, CA has garnered significant attention. Ionizing radiation (IR) extensively utilized across industrial sectors, agriculture, defense applications, scientific research, clinical medicine; however, the detrimental effects of on human health cannot be ignored. IR can...
Abstract Trichalcogenasumanenes were synthesized on a multigram scale through two‐step approach that takes advantage of non‐pyrolytic cyclization and solventless ring contraction. Solid‐state structure photophysical investigations demonstrate these compounds are promising candidates for electronic materials.
A tumor-related hypoxic microenvironment can promote the proliferation of gastric cancer cells, and hypoxic-induced autophagy is main mechanism protection against hypoxia in cells. Isorhamnetin (ISO) a chemical substance derived from plants, mainly sea buckthorn. Previous studies have shown that ISO has antitumor effects, but effects environment are still unknown. In this study, we investigated mechanisms underlying ISO-induced cell death. The results show targeted PI3K blocked PI3K–AKT–mTOR...
Five new polyketides, plakortoxides A (1) and B (2), simplextones C (3) D (4), plakorsin (5), together with six known analogues (6–11) were isolated from the South China Sea sponge Plakortis simplex. Their structures identified by spectroscopic chemical methods, including NMR, MS, IR. Experimental calculated ECD spectra modified Mosher's method used to determine absolute configurations. Structurally, both feature a butenolide coupled an epoxide moiety, while consist of γ-butyrolactone...
Cutaneous melanoma is a highly malignant skin tumor, and most patients have poor prognosis. In recent years, immunotherapy has assumed an important role in the treatment of advanced cutaneous melanoma, but only small percentage benefit from immunotherapy. A growing number studies demonstrated that prognosis with closely related to long non-coding RNA tumor immune microenvironment.We downloaded expression data immune-related gene lists separately The Cancer Genome Atlas database ImmPort...
The Huashi Baidu Formula (HSBDF), a key Chinese medical drug, has remarkable clinical efficacy in treating acute lung injury (ALI), and it been officially approved by the National Medical Products Administration of China for drug trials. Nevertheless, regulated mechanisms HSBDF its active compounds plasma against ALI were rarely studied. Based on these considerations, anti-inflammatory screened molecular docking binding free energy. further identified LC/MS. Network pharmacology was employed...