A5038243976- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Pharmacological Effects of Natural Compounds
- Protein Structure and Dynamics
- Folate and B Vitamins Research
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Salivary Gland Disorders and Functions
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Simulation and Modeling Applications
- Advanced Computational Techniques and Applications
- Oral Health Pathology and Treatment
- Natural product bioactivities and synthesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Redox biology and oxidative stress
Shandong University
2024-2025
Chinese Academy of Sciences
2014-2025
University of Science and Technology of China
2025
First Affiliated Hospital of Henan University
2025
Suzhou Institute of Nano-tech and Nano-bionics
2025
Dalian Medical University
2021-2024
Dalian University
2021-2024
York University
2024
Huashan Hospital
2024
Fudan University
2024
Software debugging is tedious and time consuming. To reduce the manual effort needed for debugging, researchers have proposed a considerable number of techniques to automate process fault localization; in particular, based on information retrieval (IR) drawn increased attention recent years. Although reportedly effective, these some potential limitations that may affect their performance. First, effectiveness likely depend heavily quality bug reports; unfortunately, high-quality reports...
Bisphenol A (BPA) can interact with nuclear receptors and affect the normal function of in very low doses, which causes BPA to be one most controversial endocrine disruptors. However, detailed molecular mechanism about how interferes is still undiscovered. Herein, dynamics simulations were performed explore interaction between three typical receptors, including hERα, hERRγ hPPARγ. The simulation results calculated binding free energies indicate that bind these receptors. affinities slightly...
Abstract Background Oral microbiota is not only important for maintaining oral health but also plays a role in various diseases. However, studies regarding microbiome changes lichen planus (OLP) are very limited. To the best of our knowledge, there has been two investigating salivary OLP. Therefore, purpose this study was to identify characteristic microbial profile saliva OLP patients, with or without erosive lesions, and compare that recurrent aphthous ulcer (RAU), common immunological...
Emerging evidence suggests the therapeutic role of autophagic modulators in cancer therapy. This study aims to identify novel traditional Chinese medicinal herbs as potential anti-tumor agents through induction, which finally lead autophagy mediated-cell death apoptosis-resistant cells. Using bioactivity-guided purification, we identified tetrandrine (Tet) from herbal plant, Radix stephania tetrandrae, an inducer autophagy. Across a number cell lines, found that breast cells treated with...
Nanomaterials (NMs) have been widely used in the biomedical field. To explore biological effects of graphene as one most NMs, we studied adsorption behavior and induced conformational changes proteins representing different secondary structures on graphene: β-strands (WW domain), mixed α/β structure (BBA protein), α-helices (λ-repressor). Our results indicate these model were adsorbed onto surface quickly tightly, however, varied degrees observed. During process, found β motif is a stiffer...
Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cells hence gains increasing interest of inhibitor discovery. Only few PGAM1 inhibitors have been reported the molecular potency remains very limited. In an effort discover inhibitors, we carried out biochemical assay-based screen was...
Natural polyphenols are one of the most actively investigated categories amyloid inhibitors, and resveratrol has recently been reported to inhibit remodel human islet polypeptide (hIAPP) oligomers fibrils. However, exact mechanism its action is still unknown, especially for full-length hIAPP1-37. To this end, we performed all-atom molecular dynamics simulations hIAPP1-37 pentamer with without resveratrol. The obtained results show that binding able cause remarkable conformational changes...
In this article, a new application of the room temperature ionic liquid, tetramethylammonium tetrafluoroborate, is described. This liquid used as stabilizing agent and reaction medium for synthesis CoFe Prussian blue analogue nanoparticles using N,N-dimethyl formamide complexing agent. The as-synthesized analogues were characterized by various techniques to catalyze epoxidation styrene. catalytic activity prepared in was superior that aqueous solution.
EGCG possesses the ability of disaggregating existing amyloid fibrils which were associated with many age-related degenerative diseases. However, molecular mechanism to disaggregate these is poorly known. In this work, study influence on full-length human islet polypeptide 1–37 (hIAPP1–37) oligomers, dynamics simulations hIAPP1–37 pentamer and decamer performed, respectively. The obtained results indicate that indeed destabilized oligomers. nematic order parameter secondary structure...
Lung cancer and breast both are extremely threatening to humans, so it is needed develop safe effective drugs for the treatment of these two ailments. To improve activity selectivity bioactive natural product oleanolic acid (OA), triphenylphosphonium moieties were introduced at different sites OA core skeleton. The in vitro antiproliferative screening results displayed that anticancer all target compounds was significantly improved, some derivatives strong cells (MCF-7) lung (A549) over...