A5008737588- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Toxin Mechanisms and Immunotoxins
- Advanced Drug Delivery Systems
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Transgenic Plants and Applications
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Immune Cell Function and Interaction
- Advanced Nanomaterials in Catalysis
- Lung Cancer Research Studies
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
Shanghai Institute of Materia Medica
2016-2025
Chinese Academy of Sciences
2016-2025
Nanjing University of Chinese Medicine
2022-2025
Zhongshan Hospital
2025
Sun Yat-sen University
2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Guangzhou University of Chinese Medicine
2023-2024
University of Chinese Academy of Sciences
2017-2024
Southern Medical University
2023-2024
Guiyang Medical University
2024
Nutrient transporters have been explored for biomimetic delivery targeting the brain. The albumin-binding proteins (e.g., SPARC and gp60) are overexpressed in many tumors transport of albumin as an amino acid energy source fast-growing cancer cells. However, their application brain has rarely investigated. In this work, gp60 overexpression was found on glioma tumor vessel endothelium; therefore, such pathways were use brain-targeting delivery. We developed a green method blood-brain barrier...
Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed further improve the in situ penetration efficiency of chemo-drug-loaded delivery-system formulations release profiles at tumor site. Here, a macrophage-membrane-coated nanoparticle developed for tumor-targeted chemotherapy with controlled profile...
A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the into cytosol, where cationic polymer subsequently oxidized by intracellular reactive oxygen species converts being negatively charged, efficiently releasing DNA. The delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin. As a service our authors readers, this journal provides supporting information supplied authors. Such...
The intrinsic or acquired drug resistance is the main challenge for cancer chemotherapy today. So far, many nanosized delivery systems (NDDS) have been exploited to combat resistance. However, therapy efficacy of current NDDS severely impaired by limited tumor penetration nanoparticles due existence physiological and pathological barriers in solid tumor. In this study, we report on design fabrication intracellularly acid-switchable multifunctional micelles combinational photo- drug-resistant...
A dual-targeting biomimetic codelivery and treatment strategy was developed for anti-glioma activity.
Chemotherapy is one of the most important strategies for glioma treatment. However, "impermeability" blood-brain barrier (BBB) impedes chemotherapeutics from entering brain, thereby rendering very few drugs suitable therapy, letting alone application a combination chemotherapeutics. Thereby, there pressing need to overcome obstacles. A dual-targeting strategy was developed by magnetic guidance and transferrin receptor-binding peptide T7-mediated active targeting delivery. The T7-modified...
Epithelial-mesenchymal transition (EMT) is closely associated with the development of drug resistance.Lipid metabolism plays an important role in EMT.This work was to study cholesterol-lowering simvastatin for reversing EMT-associated resistance chemotherapy via lipid metabolism.Methods: The combination and paclitaxel used overcome resistance.For dual-action on both cancer cells tumor-associated macrophages (TAM), tumor microenvironment-activatable multifunctional liposomes were developed...
Remodeling tumor immune microenvironment (TIME) is an important strategy to lift the immunosuppression and achieve normalization. In this work, a mannosylated lactoferrin nanoparticulate system (Man-LF NPs) developed for dual-targeting biomimetic codelivery of shikonin JQ1 via mannose receptor LRP-1 that are overexpressed in both cancer cells tumor-associated macrophages. The Man-LF NPs can serve as multitarget therapy inducing cell death cells, repressing glucose metabolism repolarizing...
Abstract Multidrug resistance (MDR) is an issue that not only related to cancer cells but also associated with the tumor microenvironments. MDR involves complicated cellular events and crosstalk between their surroundings. Ideally, effective system against should take dual action on both The authors find drug‐resistant colon protumor M2 macrophages highly express two nutrient transporters, i.e., secreted protein acidic rich in cysteine (SPARC) mannose receptors (MR). By targeting SPARC MR, a...
Disulfiram (DSF), an alcohol-aversion drug, has been explored for cancer treatment. Copper diethyldithiocarbamate (Cu(DDC)2) complex formed by DSF and copper ions is a major active ingredient its anticancer activity. Direct administration of Cu(DDC)2 promising strategy to enhance the efficacy DSF. However, efficient drug delivery remains significant challenge hinders clinical use. In this study, we developed facile stabilized metal ion ligand (SMILE) method prepare nanoparticles (NPs). The...
Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and crucial metastasis relapse. Combination therapy an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine combination effect <i>in vivo</i>, especially when greatly physicochemical properties (e.g., those macromolecules small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They...
Gefitinib is a first-line therapy in the EGFR-mutated nonsmall cell lung cancer (NSCLC). However, development of drug resistance almost unavoidable, thus leading to an unsustainable regimen. EGFRT790M mutation major cause responsible for molecular-targeting failure NSCLC. Although recently approved osimertinib effective EGFRT790M-positive NSCLC, osimertinib-resistant EGFR rapidly developed, too. In this study, we proposed tumor-associated macrophage (TAM) reprogramming strategy overcoming...
Background Glioblastoma (GBM) treatment is undermined by the suppressive tumor immune microenvironment (TIME). Seek for effective methods brain TIME modulation a pressing need. However, there are two major challenges against achieving goal: first, to screen drugs with TIME-remodeling functions and, second, develop targeting system delivering drugs. Methods In this study, an α7 nicotinic acetylcholine receptors (nAChRs)-binding peptide D CDX was used modify codelivery liposomes achieve...