A5079752398- Granular flow and fluidized beds
- Landslides and related hazards
- Pharmacological Effects and Toxicity Studies
- Particle Dynamics in Fluid Flows
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Fiber Laser Technologies
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Soil and Unsaturated Flow
- Systemic Lupus Erythematosus Research
- Neurosurgical Procedures and Complications
- Immune Cell Function and Interaction
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Trigeminal Neuralgia and Treatments
- Nanoplatforms for cancer theranostics
- Advanced Fiber Optic Sensors
- Immune cells in cancer
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Drug Transport and Resistance Mechanisms
- Heavy Metal Exposure and Toxicity
Sichuan University
2006-2025
West China Hospital of Sichuan University
2023-2025
University of Missouri–Kansas City
2025
Saint Luke's Hospital
2025
University of Virginia
2023-2024
Zhujiang Hospital
2024
Southern Medical University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Huazhong University of Science and Technology
2021-2024
A dual-targeting biomimetic codelivery and treatment strategy was developed for anti-glioma activity.
Abstract Multidrug resistance (MDR) is an issue that not only related to cancer cells but also associated with the tumor microenvironments. MDR involves complicated cellular events and crosstalk between their surroundings. Ideally, effective system against should take dual action on both The authors find drug‐resistant colon protumor M2 macrophages highly express two nutrient transporters, i.e., secreted protein acidic rich in cysteine (SPARC) mannose receptors (MR). By targeting SPARC MR, a...
Postencephalitic epilepsy (PEE) is a severe neurological complication following encephalitis. Early identification of individuals at high risk for PEE important timely intervention. To develop large self-supervised vision foundation model using big dataset multi-contrast head MRI scans, followed by fine-tuning with data and follow-up outcomes from patients to association model. Retrospective. Fifty-seven thousand six hundred twenty-one contrast-enhanced scans 34,871 construction, 144...
In the initially published version of this article, Figure 8A contains misplaced images.The corrected 8 is provided below.The correction does not affect conclusions work.The authors apologize for any inconvenience or misunderstanding that error might have caused.CorreCtion 8.In vivo imaging NPs biodistribution in mice bearing HCT8/ADR subcutaneous xenograft tumors.A) Whole body from 0.5 to 24 h.B) radiant efficiency tumor sites.C) Imaging major organs dissected mice.D) tumors mice.E) Ex tumors.
Fucoidan is a natural bioactive product with broad therapeutic applications. Hepatocellular carcinoma (HCC) common malignancy of the liver associated relatively high mortality rate; thus, effective treatments are urgently needed. Here, effects fucoidan on HCC and underlying mechanism were explored.The proliferation apoptosis two cell lines (BEL-7402 LM3) treated different concentrations or saline assessed. The levels proliferating nuclear antigen (PCNA) CCK8 assay used to determine...
OBJECT Trigeminal neuralgia is often associated with nerve atrophy, in addition to vascular compression. The authors evaluated whether cross-sectional areas of different portions the trigeminal on preoperative imaging could be used predict outcome after microvascular decompression (MVD). METHODS A total 26 consecutive patients unilateral Type 1a underwent high-resolution fast-field echo MRI cerebellopontine angle followed by MVD. Preoperative images were reconstructed and reviewed 2...
This study proposes a UI interface generation method based on diffusion model, aiming to achieve high-quality, diversified, and personalized design through generative artificial intelligence technology. The model is its step-by-step denoising process. By combining the conditional mechanism, optimization module, user feedback can generate that meets requirements multimodal inputs such as text descriptions sketches provided by users. In study, complete experimental evaluation framework was...
Abstract In this study, the PtCu bimetallic electrode is employed as anode for electrolysis of liquid ammonia. A simple co-doping approach adopted to fabricate alloys with improved activity and durability. The synthesized electrocatalysts are characterized by cyclic voltammetry (CV), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy
(EDS). electrochemical performance, crystal structure, surface morphology, elemental distribution electrodes...
Background No randomized controlled trial has successfully compared outcomes between endovascular coiling and microsurgical clipping for unruptured intracranial aneurysms (UIAs). Objective To perform a cost comparison index hospitalizations of patients with UIAs treated coil embolization or surgical to identify the current primary drivers costs either management approach. Methods We obtained hospitalization 125 cases from 2010 2012 at our institution. Comparisons were stratified based on...
Mechanical thrombectomy is effective in acute ischemic stroke secondary to emergent large-vessel occlusion, but optimal efficacy contingent on fast and complete recanalization. First-pass recanalization does not occur the majority of patients. The authors undertook this study determine if anatomical parameters intracranial vessels impact likelihood first-pass
Flowing granular materials segregate due to differences in particle size (driven by percolation) and density buoyancy). Modelling the segregation of mixtures large/heavy particles small/light is challenging opposing effects two mechanisms. Using discrete element method (DEM) simulations combined we show that velocity well described a model depends linearly on local shear rate quadratically species concentration. Concentration profiles predicted incorporating this into continuum...
Abstract Aims This multicenter prospective cohort study (registration no. ChiCTR2000032089) aimed to investigate the relationship between saliva and plasma levetiracetam concentrations determine whether could be used for routine monitoring of during pregnancy. Methods The slot in simultaneously obtained samples were measured using UPLC–MS/MS. correlations dose‐normalized compared among pregnant women different stages nonpregnant control participants with epilepsy. Results In total, 231...
Abstract Thermal degradation behaviors of polyoxymethylene in nitrogen are systematically studied by Thermogravimetry–Fourier Transform infrared spectroscopy (TG–FTIR). Two primary mechanisms definitely determined the production formaldehyde and carbon monoxide collected from successive FTIR spectrum. First, POM tends to split off starting at unstable chain‐ends, then random chain scission occurs elevated temperature, several related reactions possibly occur during process. The results prove...
Abstract Background Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment risk intracranial ischemic stroke (IS). We present the design fourth INTEnsive ambulance-delivered Reduction hyper-ACute Trial (INTERACT4). Methods A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed...
In recent years, social network sentiment classification has been extensively researched and applied in various fields, such as opinion monitoring, market analysis, commodity feedback. The ensemble approach achieved remarkable results tasks due to its superior performance. primary reason behind the success of methods is enhanced diversity base classifiers. boosting method employs a sequential structure construct diverse data while also utilizing erroneous by assigning higher weights...
Although a growing body of research has indicated strong link between oxidative stress and epilepsy, the exact nature their interaction remains elusive. To elucidate this intricate relationship, we conducted bidirectional Mendelian randomization (MR) analysis employing two independent datasets.
Granular materials are characterized by large collections of discrete particles, where the particle-particle interactions significantly more important than particle-fluid interactions. The current kinetic theory captures fairly accurately granular flow behavior in dilute case, when only binary significant, but is not accurate at all dense regime, multi-particle and contacts must be modeled. To improve results for flows we propose a Modified Kinetic Theory (MKT) model that utilizes contact...
A kinetic-theory-based model of granular flow which predicts the depth-varying segregation velocities rising and sinking particles in density-bidisperse mixtures is presented. The velocity results from a balance between buoyant force, due to particle density concentration, interspecies drag force kinetic theory, depends on interparticle friction local conditions.
Abstract Background Our previous studies have suggested that bromodomain protein 4 (BRD4) is increased in the lung of stable chronic obstructive pulmonary disease (COPD) patients, which has been shown to be involved inflammatory responses. We investigated its role viral exacerbation COPD. Methods BRD4, interleukin (IL)-6 and IL-8 were measured blood sputum COPD patients with exacerbation. Mice exposed cigarette smoke (CS) and/or infected influenza virus as an vivo model. IL-6...