Menglu Ouyang
A5032910468- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Clinical practice guidelines implementation
- Health Policy Implementation Science
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Delphi Technique in Research
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Cardiovascular Health and Risk Factors
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
- Global Maternal and Child Health
- Renal and Vascular Pathologies
- Global Public Health Policies and Epidemiology
The George Institute for Global Health
2019-2025
UNSW Sydney
2019-2025
Peking University
2019-2024
George Institute for Global Health
2019-2024
Tongji University
2024
Shanghai University of Traditional Chinese Medicine
2024
Seventh People's Hospital of Shanghai
2024
Shanghai East Hospital
2024
Shanghai University of Medicine and Health Sciences
2024
Fudan University
2024
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols early intensive lowering and management algorithms hyperglycaemia, pyrexia, abnormal anticoagulation, implemented in hospital setting, could improve outcomes patients with spontaneous
Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated stroke uncertain.
BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, substantial defined as ≥1, ≥2, ≥3, ≥4 points decrease, respectively, National Institutes Health Stroke Scale 24 hours to 7 days...
Background: Hematoma volume is an important predictor of outcome in spontaneous intracerebral hemorrhage (ICH). Location-specific hematoma thresholds are associated with poor and can inform surgical trial inclusion criteria clinical decision rules for evacuation. In a pooled dataset, we evaluated associations between ICH location, thresholds, patient outcomes. Methods: We performed secondary analysis the ATACH-2 trial. intraparenchymal location-specific cutoffs (thalamic, basal ganglia,...
Abstract The Optimising Blood Pressure in acute intracerebral hemorrhage (ICH) study aims to conduct an IPDMA of pooling the four INTERACT trial provide reliable information on optimal blood pressure (BP) treatment target for patients with ICH. This protocol outlines methods systematic review, research questions, and approach statistical analysis. An intention-to-treat principle (ITT) will be applied all analyses. Baseline characteristics summarised by group. BP lowering effect outcomes...
BACKGROUND: Cerebral swelling in relation to cytotoxic edema is a predictor of poor outcome acute ischemic stroke (AIS) and elevated blood pressure (BP) promotes its development. Whether intensive BP-lowering treatment reduces cerebral uncertain. We aimed determine whether BP lowering the severity after thrombolysis for AIS. METHODS: A secondary analysis ENCHANTED (Enhanced Control Hypertension Thrombolysis Stroke Study), partial factorial, international, multicenter, open-label, blinded end...
Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing disproportionately high burden poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, organized units being either absent or rarely available, contributing to the rates in region. To address this issue, Tanzania Project (TSP) was launched, aimed at establishing services two largest tertiary centers collaboration Tanzanian Ministry Health, World Organization Hospital...
Background Dysphagia is associated with aspiration pneumonia after stroke. Data are limited on the influences of dysphagia screen and assessment in clinical practice. Aims To determine associations between a “brief” “detailed” outcomes acute stroke patients. Methods A prospective cohort study analyzed retrospectively using data from multicenter, cluster cross-over, randomized controlled trial (Head Positioning Acute Stroke Trial [HeadPoST]) 114 hospitals nine countries. HeadPoST included...
BACKGROUND: The optimal cut point of baseline National Institutes Health Stroke Scale (NIHSS) and Glasgow Coma scores for prognosticating acute intracerebral hemorrhage (ICH) is unknown. METHODS: Secondary analyses participant data are from the INTERACT (Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trials) 1 2 studies. Receiver operating characteristic were used to compare predictive performance NIHSS scores, ICH score, max-ICH score. Optimal points predicting 90-day...
<b><i>Introduction:</i></b> We aimed to determine predictors of early (END) and delayed neurological deterioration (DND) their association with the functional outcome in patients acute ischemic stroke (AIS) who participated international Enhanced Control Hypertension Thrombolysis Stroke Study (ENCHANTED). <b><i>Methods:</i></b> END DND (without END) were defined as scores a ≥2-point increase on National Institutes Health Scale (NIHSS) or...
Abstract Background Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment risk intracranial ischemic stroke (IS). We present the design fourth INTEnsive ambulance-delivered Reduction hyper-ACute Trial (INTERACT4). Methods A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed...
Abstract Background and aims Uncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered Reduction hyper-Acute stroke Trial (INTERACT4) to determine efficacy safety hyperacute intensive BP patients with suspected Given concerns this treatment pre-hospital setting, particularly relation intracerebral hemorrhage, we provide an update on progress study profile participants date. Methods INTERACT4 is ongoing multicentre,...
Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly. We aimed illustrate how the services were interrupted during in China. Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who involved treating patients with from 1 February 31 March 2020. Results total 415 respondents online survey after informed consent obtained. Of respondents, 37.8%,...