A5018031518- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- HIV-related health complications and treatments
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Vitamin D Research Studies
- HIV Research and Treatment
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Disaster Response and Management
- Hepatitis B Virus Studies
- COVID-19 and healthcare impacts
- Mycobacterium research and diagnosis
- Hepatitis Viruses Studies and Epidemiology
- Iron Metabolism and Disorders
- Viral Infections and Vectors
- Infectious Diseases and Tuberculosis
- ICT in Developing Communities
- Acute Ischemic Stroke Management
Ministry of Health, Community Development, Gender, Elderly and Children
2023-2025
Muhimbili University of Health and Allied Sciences
2014-2024
Muhimbili National Hospital
2021-2024
Ministry of Health and Social Welfare
2023
Bugando Medical Centre
2023
Management and Development for Health
2017-2021
Karolinska Institutet
2014-2018
Karolinska University Hospital
2017
Hepatitis B vaccination for healthcare workers (HCWs) is a key component of the WHO Elimination Strategy 2016–2021. Data on current hepatitis vaccine coverage among health care in Sub-Saharan Africa are scarce, but these data vital effective programming. We assessed proportion HCWs vaccinated and factors associated with adequate at national hospital Tanzania. A descriptive cross-sectional study was conducted consenting between 30th July September 2015. Vaccination histories were obtained...
To evaluate the prevalence of HIV/hepatitis B virus (HBV) co-infection and relationship between HIV/HBV health outcomes in a cohort HIV-infected adults receiving antiretroviral treatment (ART) urban Tanzania.Clinical immunologic responses to ART were compared longitudinally HIV mono (HIV) co-infected (HIV/HBV) enrolled November 2004 September 2011 at Management Development for Health (MDH)-PEPFAR Care Treatment program Dar es Salaam, Tanzania.The was 6.2% (1079/17,539). Compared patients,...
Background Pulmonary tuberculosis and anemia are both prevalent in Tanzania. There is limited inconsistent literature on the association between sputum conversion following treatment. Methods Newly diagnosed smear positive pulmonary patients aged ≥15 years initiating standard anti therapy were recruited from 14 of 54 clinics Dar es Salaam. Patients receiving medication according to recommended short course Directly Observed Therapy (DOT) strategy followed up prospectively until completion...
Background: Studies from the Sub-Saharan African (SSA) countries suggest an underestimate of SARS-CoV-2 infections early in pandemic. To understand and inform infection control strategies to protect key vulnerable populations, this study investigated seroprevalence factors associated with anti-SARS CoV-2 seropositivity among healthcare workers (HCWs) Dar es Salaam, Tanzania. Methods: This cross-sectional was conducted three tertiary national hospitals Employed HCWs aged >=18 years were...
Tanzania is currently scaling-up access to anti-retro viral therapy (ART) reach as many eligible persons possible. Hepatitis co-infections are known influence progression, management well outcome of HIV infection. However, information scarce regarding the prevalence and predictors hepatitis co-infection among HIV-infected individuals presenting at care treatment clinics in country. A cross-sectional study conducted between April September 2006 enrolled 260 HIV-1 infected, HAART naïve...
Introduction In March 2023, a Marburg Virus Disease (MVD) outbreak was declared in Kagera region, Northwestern Tanzania. This the first MVD country. We describe epidemiological characteristics of cases and contacts. Methods The Ministry Health activated an response team. Outbreak investigation methods were applied to identified through standard case definitions confirmed reverse-transcriptase polymerase chain reaction (RT PCR). All contacts added into contact listing form followed up...
Background The emergence of HIV drug resistance mutations (DRMs) is significant threat to achieving viral suppression (VS) in the quest achieve global elimination targets. We hereby report virologic outcomes and patterns acquired DRMs its associated factors among adolescents young adults (AYA) from a broader surveillance conducted Tanzania. Methods Data AYA was extracted cross-sectional study 36 selected facilities using two-stage cluster sampling design. Dried blood spot (DBS) samples were...
Viral Haemorrhagic Fever Outbreak presents a significant public health threat, requiring timely, robust, and well-coordinated response. This paper aims to describe the roles of Tanzania Field Epidemiology Laboratory Training Program (TFELTP) graduates residents in responding Tanzania’s first Marburg Disease (MVD) outbreak. We performed secondary data analysis using range documents, such as rosters deployed responders TFELTP graduate resident database, count them. Additionally, we conducted...
Marburg viral disease (MVD) is a highly infectious with case fatality rate of up to 90%, particularly impacting resource-limited countries where implementing Infection Prevention and Control (IPC) measures challenging. This paper shares the experience how Tanzania has improved its capacity prevent control diseases, this was utilized during outbreak MVD that occurred for first time in country 2023.In 2016 subsequent years, conducted self external assessments revealed limited IPC responding...
HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months treatment. Observational studies high-income resource-limited settings indicate that with low vitamin D levels may be at increased risk mortality, HIV disease progression, incidence pulmonary tuberculosis (TB). As a result, D3 supplementation improve survival treatment outcomes for ART. The Trial Vitamins-4 (ToV4) is an...
The scale and impact of background isoniazid resistance in TB- HIV-endemic countries requires definition to improve treatment success guide the scale-up preventive therapy (IPT). We describe effects on TB outcomes among patients with or without HIV infection Dar es Salaam, Tanzania.A multicentre, prospective observational study was conducted commencing WHO-recommended first-line treatment. In multivariate analysis we ascertained relationship between at presentation a composite poor (death,...
Intact immune responses to cytomegalovirus (CMV) and Epstein-Barr virus (EBV) represent a biologically clinically relevant correlate of 'immunological fitness' in humans. However, there is lack knowledge concerning anti-EBV or anti-CMV patients with pulmonary tuberculosis (TB), whom aberrant may promote progression clinical disease.Venous blood samples were obtained at the time (sputum smear positive) TB diagnosis. A whole assay was performed by exposing PBMCs (peripheral mononuclear cells)...
Background Surveillance and effective management of drug resistance is important to sustaining tuberculosis (TB) control efforts. We aimed determine rates first line anti drugs describe factors associated with the any in Dar es Salaam Tanzania. Materials Newly diagnosed, TB patients neither history treatment nor isoniazid prophylaxis were included into study. Sputum specimens cultured on either mycobacteria growth indicator tube 960 (MGIT 960) or Lowenstein Jenstein (LJ) medium supplemented...
Purpose This paper aims to determine factors that influence people living with HIV (PLHIV) engage in internet-based information seeking behaviour selected Tanzanian public regional hospitals. Design/methodology/approach The authors conducted a questionnaire-based survey 221 PLHIV two hospitals Mwanza and Dar es Salaam, Tanzania. They assessed the validity reliability of measurement model by using exploratory factor analysis also used hierarchical regressions examine research hypotheses...
Recurrent pulmonary tuberculosis (RPTB) is a growing, important and neglected problem affecting treated TB patients health services across the world, particularly in sub-Saharan Africa. Analyses identification of differences clinical features between recurrent PTB newly diagnosed may lead to improved management recommendations.Between September 1st 2019 January 31st 2020, we performed prospective case controlled study imaging with compared them those cases. was defined as patient...
Adults living with HIV (ALHIV) are at increased risk of developing metabolic syndrome (MetS). Several factors associated an increase in MetS these individuals, including certain antiretroviral therapies (ART). There is limited data on the prevalence among ALHIV sub-Saharan Africa following scale up newer integrase inhibitor-containing ART regimens.
Background: Stroke is a second leading cause of death globally, with an estimated one in four adults suffering stroke their lifetime. We aimed to describe the clinical characteristics, quality care, and outcomes urban Northwestern Tanzania. Methods: analyzed de-identified data from prospective registry Bugando Medical Centre Mwanza, largest city Tanzania, between March 2020 October 2022. This included all ⩾18 years admitted our hospital who met World Health Organization definition stroke....