A5100446963- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Cerebrospinal fluid and hydrocephalus
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- COVID-19 and Mental Health
- Spinal Dysraphism and Malformations
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Fetal and Pediatric Neurological Disorders
- Microtubule and mitosis dynamics
- Prostate Cancer Treatment and Research
- Melanoma and MAPK Pathways
- Combustion and Detonation Processes
- Multiple and Secondary Primary Cancers
- Intellectual Capital and Performance Analysis
Yunnan Normal University
2024
Nanjing University of Chinese Medicine
2024
Fudan University Shanghai Cancer Center
2020-2024
Shanghai Medical College of Fudan University
2021-2024
Fudan University
2024
Shanghai Jiao Tong University
2024
Renji Hospital
2016-2022
Third Affiliated Hospital of Harbin Medical University
2022
State Key Laboratory of Oncogene and Related Genes
2021-2022
Zhejiang Chinese Medical University
2022
Abstract Although the newly developed second-generation anti-androgen drug enzalutamide can repress prostate cancer progression significantly, it only extends survival of patients by 4–6 months mainly due to occurrence resistance. Most previous studies on AR antagonist resistance have been focused signaling. Therefore, non-AR pathways remain largely unknown. By using C4-2, CWR22Rv1 and LNCaP cell lines, as well mice bearing xenografts treated with either or metformin alone in combination, we...
Adenoma detection rate (ADR) is a key colonoscopy quality indicator in Western clinical literature. Our low ADR prompted us to assess novel methods improve performance. retrospective reports suggested that water exchange (WE) could increase ADR. However, most of these studies used pain score or intubation as the primary outcome. Here we test hypothesis WE significantly increases among Chinese colonoscopists and design prospective randomized controlled trial using our outcome.This...
Abstract Purpose: (i) To investigate the expression of E3 ligase, RNF126, in human invasive breast cancer and its links with outcomes; (ii) to test hypothesis that RNF126 determines efficacy inhibitors targeting cell-cycle checkpoint kinase, CHEK1. Experimental Design: A retrospective analysis by immunohistochemistry (IHC) compared staining 110 78 paired adjacent normal tissues clinicopathologic data. Whether controls CHEK1 was determined chromatin immunoprecipitation a promoter driven...
The relationship between IL-17A and cancer, whether beneficial or antagonistic, continues to be a controversial issue. In this study, effects of on lung adenocarcinoma were investigated using cancer cell lines, 95D 95C. the presence absence IL-17A, proliferation VEGF secretion detected. Effects capillary networks process angiogenesis also evaluated. vivo, level was assayed in serum patients. At same time, slices tissue analyzed for expression its receptor (IL-17RA), VEGF, CD4(+)-IL-17A+...
Background The COVID-19 outbreak has increased challenges associated with health management, especially cancer management. In an effort to provide continuous pharmaceutical care patients, Sun Yat-sen University Cancer Center (SYSUCC) implemented a remote pharmacy service platform based on its already existing web-based hospital app known as Cloud SYSUCC. Objective aim of this study was investigate the characteristics, acceptance, and initial impact SYSUCC during in tertiary China. Methods...
Tumorigenic cells, when facing a hostile environment, may enter dormant state, leading to long-term tumor survival, relapse, and metastasis.To date, the molecular mechanism of cell dormancy remains poorly understood.Methods: A soft, 3-dimentional (3D) fibrin gel culture system was used mechanically select grow highly malignant tumorigenic melanoma tumor-repopulating cells (TRCs).We cultured control TRCs, TRCs with Sox2 knockdown, knockout, 2D for in vitro vivo experiments.Western blotting,...
Rationale: Glucagon-like peptide-1 is an endogenous incretin that plays active role in weight loss and hypoglycemia. Dulaglutide a long-acting glucagon-like receptor agonist (GLP-1RA), which has been approved for the treatment of patients with type 2 diabetes (T2D). GLP-1RAs can increase insulin secretion inhibit glucagon release, thereby leading to decrease blood glucose levels within body. Specifically, control postprandial by inhibiting hepatic production delaying gastric emptying....
Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly. We aimed illustrate how the services were interrupted during in China. Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who involved treating patients with from 1 February 31 March 2020. Results total 415 respondents online survey after informed consent obtained. Of respondents, 37.8%,...
Genetic factors contribute to more than 40% of prostate cancer risk, and mutations in BRCA1 BRCA2 are well-established risk factors. By using target capture-based deep sequencing identify potential pathogenic germline mutations, followed by Sanger determine the loci we identified a novel mutation caused cytosine-to-guanine base substitution at position 4211, resulting protein truncation (p.Ser1404Ter), which was confirmed immunohistochemistry. Analysis peripheral blood also benign...
Homologous recombination deficiency (HRD) is a well-known biomarker which could predict poly-ADP ribose polymerase 1 (PARP) inhibitor and platinum drug response. As an aggressive cancer, small-cell lung cancer (SCLC) sensitive to drugs, but relapse occurs rapidly. Herein, we aim illustrate the genomic alteration patterns of homologous repair (HRR)-related genes in Chinese SCLC cohort further analyze relationship among HRR gene mutations known biomarkers immune checkpoint (ICI) response,...
Controlled release studies and theoretical investigations on two complexes based tebuconazole were carried out to explain their increased antifungal activities.
Azole compounds have attracted commercial interest due to their high bactericidal and plant-growth-regulating activities. Uniconazole [or 1-(4-chlorophenyl)-4,4-dimethyl-2-(1 H -1,2,4-triazol-1-yl)pent-1-en-3-ol] is a highly active 1,2,4-triazole fungicide plant-growth regulator with low toxicity. The pharmacological toxicological properties of many drugs are modified by the formation metal complexes. Therefore, there much in exploiting coordination chemistry triazole pesticides potential...
Objective This study investigated the cost‐effectiveness of a community‐based colorectal cancer‐screening program (C‐CRCSP) in Shanghai, China, among residents urban, suburban and rural areas. Methods A Markov model was constructed to evaluate 25‐year annual C‐CRCSP including 100 000 populations. Cost‐effectiveness determined by incremental ratio (ICER); referring either life‐years gained, or quality‐adjusted (QALYs) gained. The threshold gross domestic product per capita. Univariate...
Background: To date, the role of programmed death ligand-1 (PD-L1) messenger RNA (mRNA) derived from tumor-educated platelets (TEPs) has not been well investigated in patients with advanced non-small cell lung cancer (NSCLC). A few reports have examined whether mRNA TEPs can predict clinical responses NSCLC following immunotherapy. This study aimed to identify novel biomarkers improve benefits and outcomes patients.
Dividend policy is a considerable element that impact share price significantly, and the efficiency of dividend has gained increasing attention from stakeholders researchers. There no exact answer to reasons aims changing payout methods. Thus, this paper examined methods by testing relationship between price, on trend prediction, factors caused change yearly. This selected 11 companies FTSE All-Share Index at London Stock Exchange data are collected 2003 2018. By providing evidence per...
Background: Tumor Immune Dysfunction and Exclusion (TIDE) integrated the signatures of T-cell dysfunction exclusion, exhibited significant predictive performance for immune checkpoint inhibitors efficacy. This study investigated correlation between pathomic model TIDE, including its value chemoimmunotherapy treatment response in patients with lung adenocarcinoma (LUAD).Methods: The was developed validated TCGA LUAD training validation cohorts. We assessed to a cohort advanced LUAD. Gene set...
Circular RNAs (circRNAs) have been found to be linked cancer progression and metastasis, but there is not much known about their connection lung adenocarcinoma (LAC). In the previous study reported by our group, has_circ_0002360 was highly expressed in LAC tissues. The goal of this investigate potential impact LAC.
This study explores whether meeting or beating management forecasts is indicative of managerial talent. We find that the market reacts positively when firms meet beat their after controlling for analyst and forecast errors. Further analyses reveal perform better in future are more likely to retain CEOs. These findings suggest provides information on talent, which valued by investors. Next, we examine distinct from with respect indication premiums associated both firm-specific uncertainty...
Abstract: With the growing use of immune checkpoint inhibitors (ICIs), recurrent immune-related adverse events (irAEs) have become more common after recovery from initial toxicity. Here we report one case anti-PD-1-related pneumonitis in a patient with advanced thymoma, who experienced two episodes during 10 months treatment PD-1 inhibitor. By reviewing recent advances ICI-related events, summarize clinical characteristics pneumonitis, illustrate potential predictive biomarkers for irAEs,...