The prevalence of diabetes mellitus-induced erectile dysfunction (DMED) has recently increased, which prompted numerous DMED studies. Here, we conduct a bibliometric analysis relevant literature in the field and to discuss research hotspots future development directions.The Web Science Core Collection database was searched for on DMED, characterization including number articles, journals, countries/regions, institutions, authors, keywords, other information performed using VOS viewer...

Fatty acid (FA) composition is the typical quantitative trait in oil seed crops, of which study not only closely related to content, but also more critical for quality improvement oil. The double haploid (DH) population named KN with a high density SNP linkage map was applied loci (QTL) analysis FA this study. A total 406 identified QTL were detected eight components an average confidence interval (CI) 2.92 cM, explained phenotypic variation (PV) value ranged from 1.49 45.05%. Totally, 204...

Tumorigenic cells, when facing a hostile environment, may enter dormant state, leading to long-term tumor survival, relapse, and metastasis.To date, the molecular mechanism of cell dormancy remains poorly understood.Methods: A soft, 3-dimentional (3D) fibrin gel culture system was used mechanically select grow highly malignant tumorigenic melanoma tumor-repopulating cells (TRCs).We cultured control TRCs, TRCs with Sox2 knockdown, knockout, 2D for in vitro vivo experiments.Western blotting,...

Many infertile couples might experience erectile dysfunction (ED) and significant changes in the quality of sexual life psychological state though information is limited secondary men China. To determine whether primary or infertility associated with ED, disorders, performance.This was a cross-sectional survey conducted at Dongzhimen Hospital Beijing University Chinese Medicine (06/2019-01/2020). The participants completed questionnaire including general information, life, simplified...

Abstract Patients with ischemic stroke (IS) often suffered from the problem of erectile dysfunction (ED) and psychological disease. However, they are ignored because these symptoms more obvious in convalescent stage stroke, which affects quality sexual life patients. This study aimed to investigate incidence ED, life, mental state patients after as well analyze relevant risk factors affecting their status. A total 361 IS were enrolled. The international function index-5 scale was used...

Intermuscular bones, ossified from tendons within the myosepta, occur only in teleost fish. Current understanding of homology and origins intermuscular bones fishes is based mainly on morphological data. To date, there no published data regarding molecular mechanisms bone formation. In this study, we cloned gene muscle segment homeobox C (MsxC). MsxC potentially plays a role development Hemibarbus labeo, an important species cyprinid fish Chinese aquaculture industry. Sequence analysis...

Previous studies on erythropoiesis revealed that microRNAs (miRNAs) play a critical role in erythroid differentiation. Given the abundance of identified miRNAs and limited understanding miRNAs, additional examination is required. Here, two sets differentiation miRNome data were analysed to screen for novel erythroid-inhibiting miRNAs. MIR200A was selected based its pattern downregulated expression datasets during induction Overexpression K562 TF-1 cells confirmed inhibitory Further vivo...

Leeches (pinyin name Shui Zhi; Latin scientific Hirudo; Hirudinea; Hirudinidae) and centipedes Wu Gong; Scolopendridae; Chilopoda; Scolopendridae) are traditional Chinese medicines, they belong to the family entomology. A combination of leech centipede is used as an effective medicine promote blood circulation remove stasis in medicine, "leech-centipede" has been many prescriptions treat diabetic vascular disease, including erectile dysfunction (DIED). However, its specific mechanism remains...

A genomic variant in the human ADTRP [androgen-dependent tissue factor (TF) pathway inhibitor (TFPI) regulating protein] gene increases risk of coronary artery disease, leading cause death worldwide. TFPI is TF that involved coagulation. Here, we report adtrp and tfpi form a regulatory axis specifies primitive myelopoiesis definitive hematopoiesis, but not erythropoiesis or vas- culogenesis. In zebrafish, there are 2 paralogues for (i.e., adtrpl adtrp2). Knockdown expression inhibits...

The proper development of atrioventricular (AV) valves is critical for heart morphogenesis and the formation cardiac conduction system. Defects in AV valve are most common type congenital defect. Cardiac troponin I ( ctnni), a structural regulatory protein involved muscle contraction, subunit complex, but functions molecular mechanisms ctnni during early remain unclear. We created knockout zebrafish model which 1b tnni1b) Tnni-HC, craniofacial) was deleted using clustered regularly...

BACKGROUND:The aim of this study was to explore the effect obstructive sleep apnea hypopnea syndrome (OSAHS) on spermatogenesis and effects expression related proteins. MATERIAL AND METHODS:Rats in Group A were normoxic (exposed a normal level oxygen). Rats B exposed intermittent hypoxia. After 6 weeks, rats killed their epididymides removed. The epididymis one testis used test indices semen quality. other stained with hematoxylin & eosin observe pathologic changes testis. We real-time...

Huoxue Tongluo Qiwei Decoction is a classical herbal formula, which can improve the symptoms of erectile dysfunction (ED) patients and has good therapeutic effect on with diabetic (DIED). The main function to stimulate blood circulation dredge collaterals, remove stasis, calm wind.To further explore mechanism in treatment DIED, related animal experiments were designed.The chemical constituents identified help high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). A rat...

The causal relationship between obesity-related anthropometric indicators/body composition and erectile dysfunction has not been established in previous observational studies.We screened single nucleotide polymorphisms significantly associated with exposure from genome-wide association studies as instrumental variables (p < 5.0 × 10-8 ). summary statistics for were collected a study sample size of 223,805. Exposure outcome populations included are European ancestry. We used univariate...

Objective: Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the identified, we selected glucocorticoid-induced transcript 1 (GLCCI1) and stress-induced phosphoprotein (STIP1) evaluate impact of these gene polymorphisms on ICS Tunisian asthmatics.Methods: We analyzed four single nucleotide (SNPs): two GLCCI1 (rs37972 rs37973), STIP1 (rs2236647 rs2236648), which are associated...

The leech and centipede granules have good curative effects on many diabetic vascular diseases, including diabetes-induced erectile dysfunction (DIED).To explore the effect of function in rats with its possible mechanism.Thirty male Sprague-Dawley DIED were randomly divided into model group (Group M), low-dose DD), high-dose DG) tadalafil T) (n = 6); induced by streptozotocin. Apomorphine was used to induce dysfunction. 'leech-centipede' (0.15 0.6 g/kg) intragastrically administered DD DG...

Through network pharmacology research, we found that CYP19, CYP17, AR and SRD5A2 were potential targets for lycium chinense-cuscutae semen (LC-CS) treatment of oligoasthenozoospermia. Using in vitro vivo experiments, tripterygium glycosides used to induce spermatogenic dysfunction models GC-1spg cells SD male rats, respectively, LC-CS was intervene a model. In vitro, could repair the ultrastructure damaged by (TG). Compared with TG group, upregulate protein mRNA expression SRD5A2. vivo,...

Depression and chronic prostatitis (CP) are two common diseases that affect the human population worldwide. Clinically, it has been demonstrated andrological patients often simultaneously suffer from depression CP. Prior investigations have established acts as an independent risk factor for Herein, we explored correlation between CP using bioinformatics tools through animal experiments. The potential targets signalling pathways involved in were predicted tool, while rat model was restraint...

Abstract Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urinary system disease in men. As part of traditional Traditional Chinese medicine, acupuncture has been widely used clinical practice. In order to evaluate the exact effect on efficacy CP/CPPS, this experiment uses randomized controlled experiments. Methods/design: This pragmatic trial will recruit 166 patients who are diagnosed with CP/CPPS. Simple randomization conventional drug treatment 1:1...

BACKGROUND:We explored the effect of asthma on erectile dysfunction (ED) and effects expression related proteins. MATERIAL AND METHODS:We used a bioinformatics database to predict targets pathways associated with ED. The rat model was caused by an ovalbumin solution. number erections in 30 min observed injecting apomorphine into neck at dose 100 μg/kg. Rats no erection were regarded as group (group B), previous random 6 normal rats control A). We hematoxylin eosin (HE) compare tissue...

Abstract Background: Premature ejaculation (PE) is the one of most prevalent male sexual dysfunction, there has not been specific medicine or therapy for disease. As an effective treatment premature a behavioral and widely used worldwide. The purpose this study to evaluate efficacy safety in patients who suffer from PE. Method: We will search all randomized controlled trials (RCTs) following electronic databases, by September 30, 2018, such as PubMed, EMBASE, Cochrane Library, Web Science...

BACKGROUND:Studies have shown that diabetes mellitus (DM) has a negative impact on male reproductive function, which may lead to changes in the testis and epididymis decline semen quality. MATERIAL AND METHODS:We performed animal experiments with 6 diabetic db/db mice as model group (group B) C57BL/6J control A). After adaptive feeding for 7 days, sperm quality of each was measured. Concurrently, morphology mouse observed by hematoxylin-eosin (H&E) staining. The expression PI3K, Akt, FoxO1,...

This study is to verify the effect of asthma on sperm quality and explore its potential underlying mechanism. We randomly categorized Sprague-Dawley (SD) rats into control (Group C) model M) groups. Rats in group were induced allergic by intraperitoneal injection ovalbumin solution. evaluated motility concentration. The expression Interleukin-6 (IL6), phosphorylation-signal transducer activator transcription 3 (p-Stat3), hypoxia-inducible factor-1α (HIF-1α) proteins mRNAs testicular tissue...