A5041479429- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Cytokine Signaling Pathways and Interactions
- Insect Pest Control Strategies
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Arachnid Ecology and Behavior
- Adipose Tissue and Metabolism
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Cancer-related gene regulation
- Immune Response and Inflammation
- RNA Research and Splicing
- Bioactive Natural Diterpenoids Research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Oral microbiology and periodontitis research
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Cancer-related Molecular Pathways
- Heme Oxygenase-1 and Carbon Monoxide
China Agricultural University
2018-2025
Ningbo Medical Center Lihuili Hospital
2023-2024
Ningbo University
2023-2024
Qingdao University
2018-2024
Capital Medical University
2008-2024
Mianyang Central Hospital
2020-2024
University of Electronic Science and Technology of China
2024
Oklahoma State University Institute of Technology
2020-2024
Affiliated Hospital of Qingdao University
2024
First Affiliated Hospital of Jinan University
2023
Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a hallmark of EMT, but there remains an incomplete understanding the epigenetics this process. The protein arginine methyltransferase PRMT7 functions in various physiologic processes, including mRNA splicing, DNA repair, and neural differentiation, its possible roles cancer metastasis have not been explored. In report, we show that expressed at higher levels breast carcinoma cells elevated mediates EMT could...
Aberrant activation of histone methyltransferase EZH2 and ribosome synthesis strongly associate with cancer development progression. We previously found that regulates RNA polymerase III-transcribed 5S ribosomal gene transcription. However, whether is still unknown. Here, we report promotes by targeting silencing a long noncoding PHACTR2-AS1. PHACTR2-AS1 directly bound DNA genes recruited SUV39H1, which in turn triggered H3K9 methylation these genes. Depletion resulted hyperactivation...
The Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this are less well known. Here, we report the focal adhesion molecule Kindlin-2 inhibits by interacting with degrading MOB1 promoting interaction between E3 ligase praja2. thus phosphorylation of LATS1 YAP promotes translocation into nucleus, where it activates downstream target gene transcription. depletion Hippo/YAP alleviates renal fibrosis knockout mice...
Abstract Migration of epidermal stem cells ( EpSCs ) into wounds may play an important role in wound healing. Endogenous electric fields EFs arise naturally at wounds. Consistent with previous reports, we measured outward currents rat skin using vibrating probes. Topical use prostaglandin E2 significantly promoted However, it is not known whether respond to . We first isolated and characterized from skin. then demonstrated that the epidermis migrated directionally toward cathode 50–400 mV...
To screen the factors of intraoperatively acquired pressure ulcer and establish a new risk assessment model ulcer.This is prospective study.A total 1,963 patients who received neurosurgery, orthopaedics, paediatric surgery cardiac therapy in Sichuan Academy Medical Science Provincial People's Hospital China from October 2015-October 2016 were enrolled study, their clinical parameters collected. Multivariable logistic regression analysis decision tree used to analyse ulcer.The for included...
Sleep is crucial for animal physiology, primarily governed by the brain, and disruptions are prevalent in various brain disorders. Mettl5 , associated with intellectual disability (ID) often accompanied sleep disturbances, remains poorly understood its role causing these Previous research demonstrated that forms a complex Trmt112, influencing rRNA methylation. In our study, we explored phenotypes due to Drosophila mutations. Rescue experiments pinpointed ’s predominant neurons glia marked...
Sleep is crucial for animal physiology, primarily governed by the brain, and disruptions are prevalent in various brain disorders. Mettl5 , associated with intellectual disability (ID) often accompanied sleep disturbances, remains poorly understood its role causing these Previous research demonstrated that forms a complex Trmt112, influencing rRNA methylation. In our study, we explored phenotypes due to Drosophila mutations. Rescue experiments pinpointed ’s predominant neurons glia marked...
The DNA-damaging drug doxorubicin (Dox) induces cell senescence at concentrations significantly lower than those required for induction of apoptosis. At low Dox concentrations, tumor suppressor p53 is activated, which enhances the expression p21(Waf1/Cip1) (p21). high activates leading to apoptosis without enhancing p21 expression. underlying mechanisms and factors that govern differential effects in inducing are unclear. Here, we report DNA methyltransferase (DNMT) DNMT3a was upregulated by...
Background: There is increasing evidence that long non-coding RNAs (lncRNAs) are involved in the process of carcinogenesis and treatment using chemotherapy. Pterostilbene, a phytochemical agent with natural antioxidant anti-inflammatory properties, has been shown to modulate oncogenic processes many cancers. However, there limited research on association between pterostilbene expression lncRNAs. Methods: MCF7 breast cancer cells were treated various concentrations their gene profile was...
Abstract The EtOAc extract of Coreopsis tinctoria Nutt. significantly inhibited LPS-induced nitric oxide (NO) production, as judged by the Griess reaction, and attenuated elevation in iNOS, COX-2, IL-1β, IL-6 TNF-α mRNA levels, determined quantitative real-time PCR, when incubated with BV-2 microglial cells. Immunohistochemical results showed that decreased number Iba-1-positive cells hippocampal region LPS-treated mouse brains. major effective constituent extract, okanin, was further...
Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- short-sleep phenotypes, respectively. However, mechanism is still mystery. this study, we showed that juvenile hormone (JH) involved regulation of sexually sleep which gain JH function enlarges differences phenotype with higher lower females, while loss blurs these results feminization male masculinization female sleep. Further studies indicate germ...
The study was to investigate the effects of ligustrazine on rats with cerebral ischemia-reperfusion (I/R) injury and explore potential mechanism. Transient focal ischemia Wistar rat model established through middle artery occlusion. I/R were treated intraperitoneal injection (1, 3, 10 mg/kg). Human amniotic epithelial cells (HAECs) 10, 100 μM) PI3K inhibitor wortmannin (100 μM), following oxygen-glucose deprivation (OGD) treatment. expression levels protein kinase B (PKB or AKT), phospho-Akt...
Icaritin (IT) is a flavonoid isolated from Herba Epimedii. In this study, we evaluated the anti-melanoma activities of IT, and determined its cytotoxic mechanism. We found that IT exerted cytotoxicity to melanoma cells. Furthermore, induced cell apoptosis, which was accompanied with PARP cleavage. Mechanistically, suppressed p-STAT3 (tyr705) level in parallel increases (ser727), p-ERK p-AKT. significantly inhibited STAT3 nuclear translocation reduced levels -targeted genes. also...
Purpose: Retinitis pigmentosa GTPase regulator (RPGR)-related X-linked retinitis is associated with one of the most severe phenotypes among inherited retinal disease. The aim this study was to investigate Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-mediated gene editing therapy in a mouse model Rpgr. Methods: Rpgr−/yCas9+/WT male mice were used for study. At 6 months age, they received single subretinal injection adeno-associated virus vectors carrying sgRNA and donor...
Abstract BACKGROUND The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a global insect pest of crops, leading to reduction agricultural products in productivity and quality. Plant saponins are rich sources for the discovery candidates control pests. This study focused on triterpenoid from Clematis aethusifolia Turcz evaluation their antifeedant, insecticidal growth inhibitory activities against 3rd instar larvae P. xylostella. RESULTS Seven ( 1–7 ) were isolated...