A5036839742- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- TGF-β signaling in diseases
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Digital Marketing and Social Media
- Wnt/β-catenin signaling in development and cancer
- Cerebrovascular and Carotid Artery Diseases
- Hedgehog Signaling Pathway Studies
- Gender, Feminism, and Media
- Consumer Behavior in Brand Consumption and Identification
- Hippo pathway signaling and YAP/TAZ
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- CAR-T cell therapy research
- Toxoplasma gondii Research Studies
- Ear and Head Tumors
- Muscle Physiology and Disorders
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Quinazolinone synthesis and applications
- Lysosomal Storage Disorders Research
Gwangju Institute of Science and Technology
2020-2025
Zhongshan Hospital of Xiamen University
2025
University of Florida
2022-2024
Peking University
2015-2024
Dalian Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Central South University
2021
Shanghai Jiao Tong University
2021
Ministry of Education of the People's Republic of China
2015-2020
Epstein-Barr virus (EBV)-associated gastric cancer (GC) (EBVaGC) is a distinct molecular subtype of GC with favorable prognosis. However, the exact effects and potential mechanisms EBV infection on immune checkpoint blockade (ICB) efficacy in remain to be clarified. Additionally, EBV-encoded RNA (EBER) situ hybridization (ISH), traditional method detect EBV, could cause false-positive/false-negative results not allow for characterizing other biomarkers recommended by standard treatment...
The microenvironment of lymph node metastasized tumors (LNMT) determines tumor progression and response to therapy, but a systematic study LNMT is lacking. Here, we generate single-cell maps primary (PTs) paired LNMTs in 8 breast cancer patients. We demonstrate that the activation, cytotoxicity, proliferation T cells are suppressed compared with PT. CD4+CXCL13+ more likely differentiate into an exhausted state. Interestingly, LAMP3+ dendritic display lower cell priming activating ability...
Given the benefits and effectiveness of consumer online brand engagement, influencer advertising marketing have become increasingly popular on social media. Consumer including consuming, contributing, creating brand-related content, is closely related to a brand's reputation image. This study determines how two aspects endorsement—namely, influencer–follower parasocial interaction (PSI) influencer–brand congruence (congruence)—affect three levels activities (COBRAs) Sina Weibo. We also...
Activation of TGF-β/Smad signaling plays a central role in the pathogenesis tubulointerstitial fibrosis, but mechanisms underlying initial interaction TGF-β receptor with Smads, leading to their activation, remain unclear. Here, we found that Kindlin-2, an integrin-binding protein, physically mediated type I (TβRI) Smad3 human kidney tubular epithelial cells. Kindlin-2 bound TβRI through its FERM domain and N terminus. Overexpression increased TGF-β-induced activation. Knockdown...
The Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this are less well known. Here, we report the focal adhesion molecule Kindlin-2 inhibits by interacting with degrading MOB1 promoting interaction between E3 ligase praja2. thus phosphorylation of LATS1 YAP promotes translocation into nucleus, where it activates downstream target gene transcription. depletion Hippo/YAP alleviates renal fibrosis knockout mice...
Abstract Background Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility. The involvement calcium diverse metabolic pathways has been suggested. However, effect peroxisomes, which are fatty acid oxidation scavenges result reactive oxygen species (ROS), remains elusive. In addition, impaired peroxisomal ROS inhibit mammalian target rapamycin complex 1 (mTORC1) promote autophagy. Under...
Abstract The breakdown of Golgi proteins disrupts lipid trafficking, leading to accumulation in the small intestine. However, causal mechanism effects protein degradation on structure related trafficking intestine remains unknown. Here we find that occurs under hypoxic conditions high-fat-diet-fed mice. Hypoxia-induced promotes structural changes apparatus, termed ‘Golgi condensation’. In addition, hypoxia-inducible factor 1α (HIF-1α) activation enhances condensation through ubiquitination...
Purpose This study aims to explore the perceptions of follower identities among Chinese youth and formation these within context use gratification theory mediated relationships. Design/methodology/approach Interviews were conducted with 22 individuals who followed digital influencers on various social media platforms, a general inductive approach was analyze collected data. Findings The research uncovered that influencers’ followers view themselves as learners, advisees, surveillants,...
Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 known to coactivate integrins with Talin; however, molecules that restrict integrin are elusive. Here, we demonstrate the E3 ubiquitin ligase Smurf1 controls amount of protein in cells and hinders activation. interacts promotes ubiquitination degradation. selectively mediates degradation but not Talin, leading inhibition αIIbβ3 Chinese hamster ovary β1 fibroblasts. Enhanced was found...
Abstract Background Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome of damaged organelle. Whereas defective autophagy enhances cholesterol accumulation in the and impaired autophagic flux that results Niemann-Pick type C1 (NPC1) disease. However, exact interconnection between NPC1 remain obscure due existence controversial reports. Results This...
Insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is expressed in metastatic and a subset of primary renal cell carcinoma (RCC). However, the role IMP3 RCC progression was poorly understood. We aim to uncover mechanism regulating clear (CCRCC) validate prognostic significance localized CCRCC.
FHL1 has been recognized for a long time as tumor suppressor protein that associates with both the actin cytoskeleton and transcriptional machinery. We present in this study paradigm phosphorylated functions an oncogenic by promoting cell proliferation. The cytosolic tyrosine kinase Src interacts phosphorylates at Y149 Y272, which switches from to growth accelerator. Phosphorylated translocates into nucleus, where it binds transcription factor BCLAF1 promotes growth. Importantly,...
Glioblastoma (GBM) is an aggressive malignancy with poor prognosis. New treatment and therapy strategy for GBM are urgently needed. Although clinical studies have demonstrated the feasibility safety of chimeric antigen receptor (CAR) T cell GBM, efficacy not been that impressive. The major limit anti-tumor CAR-Ts immunosuppressive milieu tumor microenvironment (TME). TGFβ, a substantial component in compromises immune response contributes to evasion progression. To overcome limitation...
Kindlin-2 is an adaptor protein that contributes to renal tubulointerstitial fibrosis (TIF). Epithelial-to-mesenchymal transition (EMT) in tubular epithelial cells was regarded as one of the key events TIF. To determine whether kindlin-2 involved EMT process, we investigated its regulation human kidney (TECs) and explored underlying mechanism. In this study, found overexpression suppressed marker E-cadherin increased expression fibronectin myofibroblast α-smooth muscle actin (SMA)....
Kindlin-1, an integrin-interacting protein, has been implicated in TGF-β/Smad3 signaling. However, the molecular mechanism underlying Kindlin-1 regulation of signaling remains elusive. Here, we reported that is important mediator by showing physically interacts with TGF-β receptor I (TβRI), Smad anchor for activation (SARA) and Smad3. required interaction Smad3 TβRI, phosphorylation, nuclear translocation, finally pathway. Functionally, promoted colorectal cancer (CRC) cell proliferation...
Smad3 is the key mediator of TGF-β1-triggered signal transduction and related biological responses, promoting cell invasion metastasis in various cancers, including lung cancer. However, deubiquitinase stabilizing remains unknown. In this study, we present a paradigm which POH1 identified as novel that plays tumor-promoting role adenocarcinoma (LUAD) by regulating stability. markedly increased protein levels prolonged its half-life Smad3. directly interacted colocalizes with Smad3, leading...
Purpose Social media marketing is a great tool for entrepreneurs because of its low cost, fast response and rich interactions. This study aims to examine how use social as resources influence entrepreneurial opportunity evaluation. Design/methodology/approach The authors designed mixed methods with an open-ended question survey conjoint experiment. sent out online through M-Turk collected 355 valid responses from entrepreneurs. Findings results show that consider important their businesses...