A5065726947- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Quinazolinone synthesis and applications
- Nuts composition and effects
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Synthesis and Biological Evaluation
- Food Quality and Safety Studies
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Biochemical effects in animals
- Polysaccharides and Plant Cell Walls
- Natural Compound Pharmacology Studies
- Liver Disease Diagnosis and Treatment
- Agriculture, Soil, Plant Science
- Trace Elements in Health
- Nephrotoxicity and Medicinal Plants
Shenyang Pharmaceutical University
2016-2025
Kindai University
2010-2019
Kanion Pharmaceutical (China)
2016-2018
Yanbian University
2018
University of Nairobi
1977
Indiana University Bloomington
1977
Abstract The EtOAc extract of Coreopsis tinctoria Nutt. significantly inhibited LPS-induced nitric oxide (NO) production, as judged by the Griess reaction, and attenuated elevation in iNOS, COX-2, IL-1β, IL-6 TNF-α mRNA levels, determined quantitative real-time PCR, when incubated with BV-2 microglial cells. Immunohistochemical results showed that decreased number Iba-1-positive cells hippocampal region LPS-treated mouse brains. major effective constituent extract, okanin, was further...
Feature-based molecular networking analysis combined with bioassay-guided method was applied to afford two previously undescribed trichothecenes derivatives (1–2), together eleven (3–13) and three β-resorcylic macrolides (14–16) from an endophytic fungus Fusarium equiseti Z8. The new structures were elucidated by using comprehensive spectroscopic analyses of NMR, HR-ESI-MS, ECD calculations. All isolated compounds evaluated the antiproliferative effects against A549, NCI-H1944, NCI-H1650...
Feature-based molecular networking analysis combined with bioassay-guided method was applied to afford two previously undescribed trichothecenes derivatives (1–2), together eleven (3–13) and three β-resorcylic macrolides (14–16) from an endophytic fungus Fusarium equiseti Z8. The new structures were elucidated by using comprehensive spectroscopic analyses of NMR, HR-ESI-MS, ECD calculations. MSn fragmentation also elucidated. All isolated compounds evaluated the antiproliferative effects...
In recent years, cistanche tea has been increasingly used as a major herbal supplement in functional drinks, and it attracted growing number of consumers because its excellent tonic effects medicinal properties. Acteoside (ACT), which is the principal bioactive component Chinese tea, possesses various pharmacological effects. This study profiled, isolated, identified, investigated hepatoprotective capacities metabolites rat urine after administration ACT. Eleven metabolites, including one...
Echinacoside (ECH) and acteoside (ACT), as the most major active components of Cistanche tubulosa, were reported to possess cardioactive, neuroprotective hepatocyte protective effects, well antibacterial, antioxidative effects. Recently, more studies have focused on their pharmacological activities. However, metabolic profiles in vivo not been sufficiently investigated. This study proposes an approach for rapidly identifying complicated unpredictable metabolites ECH ACT rat plasma, bile,...
To identify phytochemical constituents present in the extract of flowers Xanthoceras sorbifolia and evaluate their anti-oxidant anti-hyperglycemic capacities. The AlCl3 colorimetric method Prussian Blue assay were used to determine contents total flavonoids phenolic acids extraction layers, bioactive layers was screened through anti − oxidative activity vitro. Waters ACQUITY UPLC system a BEH C18 column (2.0 mm × 150 mm, 5 μm) ingredients. And anti-oxidative ingredients by off-line...
Three iridoid glycosides, kankanosides L, M, and N, two acyclic monoterpene O P, were isolated from fresh stems of Cistanche tubulosa (Orobanchaceae) together with eight five three phenylpropanoid four lignan glycosides. Their structures elucidated on the basis chemical physicochemical evidence.
A HPLC method is described in order to separate and identify 4 phenolic compounds including lithospermic acid B, 3,4-dihydroxyphenyllactic (danshensu), rosmarinic acid, protocatechuic aldehyde as well 3 lipophilic ones (tanshinone I, tanshinone IIA cryptotanshinone) from the roots of Salvia miltiorrihiza or herbal product containing S. available Chinese Japanese market. The influence extractive conditions, such method, solvents time, on marker components discussed. In investigate stability...