A5101409811- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Cervical Cancer and HPV Research
- Cardiovascular and Diving-Related Complications
- Respiratory viral infections research
- Glaucoma and retinal disorders
- Airway Management and Intubation Techniques
- Cardiac and Coronary Surgery Techniques
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Flavonoids in Medical Research
- Kawasaki Disease and Coronary Complications
- Streptococcal Infections and Treatments
- Anesthesia and Sedative Agents
- Venous Thromboembolism Diagnosis and Management
- Urinary and Genital Oncology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Analysis
- Cardiac Ischemia and Reperfusion
- Pneumonia and Respiratory Infections
- Retinal Imaging and Analysis
- Head and Neck Surgical Oncology
- Vaccine Coverage and Hesitancy
- Ophthalmology and Visual Impairment Studies
Fujian Medical University
2025
Wenzhou Medical University
2023-2025
Women's Hospital, School of Medicine, Zhejiang University
2019-2025
Chinese University of Hong Kong
2024
Prince of Wales Hospital
2024
Zhejiang University
2023-2024
Beijing Dance Academy
2021-2024
Nantong University
2020-2024
Shenyang Pharmaceutical University
2024
Chengdu Women's and Children's Central Hospital
2015-2024
BackgroundCurrent labelling advises discontinuation of metformin when estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 due to increased risk lactic acidosis. However, in real-world practice, the risk-benefit ratios remain uncertain. We examined associations discontinued-metformin use with cardiorenal and clinical outcomes patients type 2 diabetes (T2D) advanced chronic kidney disease.MethodsIn this territory-wide, retrospective cohort target trial emulation study, we included...
Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory neurodegenerative diseases. Even though inhibition of TNF-α is beneficial the treatment certain diseases, total neutralization largely failed exerts distinct functions depending on interaction with two TNF receptors, whereby receptor 1 (TNFR1) associated neuroinflammation apoptosis 2 (TNFR2) neuroprotection regulation. Here, we...
Aim . To evaluate eye drop instillation technique and to explore its determinants in glaucoma patients. Methods One hundred thirteen patients diagnosed with self-administering topical antiglaucoma drops for at least 1 month were evaluated. All instilled artificial tear solution one as they would do home. The whole process was evaluated by two study staff. A comprehensive score system associated techniques used quantify the such demographic clinical characteristics. Results Half of (48.67%)...
In this study, we investigated the protective effects of ligustilide against lipopolysaccharide (LPS)-induced endotoxic shock in Japanese white rabbits and attempted to elucidate possible mechanism underlying these effects. Forty-two were randomized into 6 groups: normal group, LPS dexamethasone group (5 mg/kg), 3 groups (20, 40, 80 mg/kg). After had received a infusion (0.3 intravenously injected at above-mentioned dosages. Heart rate (HR), mean arterial pressure (MAP), rectal temperature...
The mortality rate from COVID-19 appears to be higher in solid organ transplant (SOT) recipients when compared with other populations. Vaccination is a key strategy prevent the pandemic. However, it unclear how readily SOT will get vaccinated against COVID-19. We conducted an internet-based survey investigate vaccination willingness among Chinese and further explore possible influencing factors. Eight hundred thirteen respondents participated survey. Overall, 46 (5.7%) were COVID-19, while...
In 2015, the American Society of Clinical Oncology announced that strategies using combination therapies have been indicated to be effective against many types cancer. present study, thioridazine (THZ) was used in a therapy with loratadine (LOR) target gastrointestinal tumor, aim investigating whether combined superior monotherapy its antitumor effects. The antiproliferative effects on CT26.WT and MFC cells were analyzed cell-counting kit-8 assay, synergistic effect assessed by index (Fig....
Depression is one of the most common forms mental illness and also a leading cause disability worldwide. Developing novel antidepressant targets beyond monoaminergic systems now popular necessary. LIM kinases, including domain kinase 1 2 (LIMK1/2), play key role in actin microtubule dynamics through phosphorylating cofilin. Since depression associated with atrophy neurons reduced connectivity, here we speculate that LIMK1/2 may pathogenesis depression.In this study, chronic unpredictable...
Xin-Shao formula is a folk remedy widely used in China to prevent and cure stroke. Cerebral ischemic reperfusion (I/R) injury often takes place during the treatment of Information about pharmacokinetic behavior under cerebral I/R conditions lacking. The present study aimed compare properties scutellarin paeoniflorin, two major bioactive components formula, physiological state rats. Neurobehavioral dysfunction was evaluated infarcted volume measured middle artery occlusion (MCAO) Plasma...
Background Diabetic retinopathy (DR) is deemed a microangiopathy and neurodegenerative disorder, which primary reason of visual impairment in the world. Ferritinophagy critical regulator ferroptosis has vital part etiopathogenesis DR. Nevertheless, its molecular mechanism DR remains to be expounded. Methods The GSE146615 dataset was adopted identify ferritinophagy-related differentially expressed genes (FRDEGs). interactions biological functions were described by means functional enrichment...
Mesenchymal stem cells (MSCs) are pluripotent capable of differentiating into osteocytes, adipocytes and chondrocytes. However, in osteoporosis, the balance differentiation is tipped toward adipogenesis key mechanism controversial. Researches have shown that, as upstream regulatory elements gene expression, enhancers ar involved expression identity genes. In this study, we identified enhancers-mediated FOXO3 promoting MSC adipogenic by activating autophagy.
e16667 Background: Hepatocellular carcinoma (HCC) is a heterogeneous disease that lacks molecular predictors of response to available treatments. AT-rich interactive domain 1A (ARID1A), SWI/SNF chromatin remodeling gene, commonly mutated in human cancers and hypothesized be tumor suppressor gene. In recent years, immune checkpoint blockade immunotherapies (ICIs) are promising therapies for multiple including HCC, mutation burden (TMB) was an important biomarker predict the efficacy ICIs....
To determine whether early proteins from high-risk human papillomavirus (HPV) have the capacity to maintain cellular stemness.First, we isolated cancer stem cell like cells two cervical lines, SiHa and CaSki, using non-adhesive culture with serum-free medium. Second, knocked down HPV16 E7 in sphere overexpressed U2OS cells. Third, used RNA-seq analysis Western blotting screen identify expression of differentially expressed genes knockdown.We found that both CaSki grew as spheres...
Spontaneous splenic rupture, also referred to as atraumatic is a rare but life-threatening emergency condition. Without timely diagnosis and treatment, the mortality rate of rupture approaches 100%. The etiology varies; it reportedly associated with neoplasms or infection, rarely encountered in patients both conditions. We herein report case 58-year-old male patient acute myeloid leukemia (AML) complicated by tuberculosis (TB), who presented spontaneous spleen. Pathological examination...