A5074471621- FOXO transcription factor regulation
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- HVDC Systems and Fault Protection
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Circular RNAs in diseases
Sun Yat-sen Memorial Hospital
2020-2024
Sun Yat-sen University
2020-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2020-2024
BackgroundMesenchymal stem cells (MSCs) selectively differentiate into adipocytes or osteoblasts, and several molecules control the fate determination of MSCs. Understanding these key checkpoints greatly contributes to ability induce specific MSC differentiation for clinical applications. In this study, we aimed explore whether TNF receptor-associated factor 4 (TRAF4) affects adipogenic differentiation, which previously reported that could positively regulated osteogenic...
Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by secreting monocyte chemoattractant protein 1 (MCP1). However, the regulatory mechanisms MCP1 secretion in MSCs are still unclear. Recently, N6-methyladenosine (m6A) modification was reported be involved functional regulation MSCs. In this study, we demonstrated that methyltransferase-like 16 (METTL16) negatively regulated expression...
Mesenchymal stem cells (MSCs) are pluripotent capable of differentiating into osteocytes, adipocytes and chondrocytes. However, in osteoporosis, the balance differentiation is tipped toward adipogenesis key mechanism controversial. Researches have shown that, as upstream regulatory elements gene expression, enhancers ar involved expression identity genes. In this study, we identified enhancers-mediated FOXO3 promoting MSC adipogenic by activating autophagy.