A5100395909- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA Research and Splicing
- HVDC Systems and Fault Protection
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Hybrid Renewable Energy Systems
- Nerve injury and regeneration
- Neurological diseases and metabolism
- Macrophage Migration Inhibitory Factor
- Cardiac Structural Anomalies and Repair
- Genetics and Neurodevelopmental Disorders
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
Tongji University
2024-2025
Shanghai Tenth People's Hospital
2025
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2025
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Zhengzhou University
2022-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Southern Medical University
2024
Shanghai Pulmonary Hospital
2024
Abstract microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported cancer. To gain insights into its potential role tumorigenesis, we generated knockout colon cancer cells through targeting. Unbiased microarray analysis combined with bioinformatics identified cell cycle regulator Cdc25A as a target. suppressed defined sequence 3′-untranslated region. We found is induced...
Abstract Background Laryngeal cancer has the highest mortality rate among head and neck tumours. RNA N6-methyladenosine (m6A) is most plentiful variable in mammalian mRNA. Yet, m6A regulatory mechanism underlying carcinogenesis or progression of LSCC remains poorly understood. Methods The methylation quantification kit was used to detect tissue levels. microarray analysis, mRNA transcriptomic sequencing (mRNA-seq), proteomics were determine RBM15, TMBIM6, IGF2BP3. Immunohistochemical (IHC),...
Abstract Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we demonstrated that enhanced osteogenic differentiation MSC from AS patients (AS-MSC) resulted osteogenesis, during course, AS-MSC induced TNF-α-mediated local inflammation. However, whether TNF-α turn affects remains unknown. Herein, further demonstrate high-concentration treatment triggers directional migration vitro vivo,...
Objective There is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic (ALD), viral hepatitis, but no studies have explored their causal relationship. Methods Instrumental variables of the (N = 13266) microbiota-derived metabolites 7824) were acquired, a Mendelian randomization study was performed to explore influence on NAFLD (1483 European cases 17,781 controls), ALD (2513 332,951 hepatitis risk (1971 340,528 controls). The main...
Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence closely related to organic development aging-related diseases such as osteoarthritis (OA). m6A a common RNA modification plays an important role in regulating biological functions, ALKBH5 one key demethylases. However, MSC still unclear. Here, we found level was enhanced expression decreased MSCs induced by multiple replications, H2O2 stimulation or UV...
Translation machinery associated 7 homolog (TMA7) is closely related to proliferation-related diseases. However, the function and regulatory mechanism of TMA7 in laryngeal squamous cell carcinoma (LSCC) remain unclear. The present study aimed investigate effect on occurrence development LSCC TMA7. upregulated tissues with poor prognosis. After downregulation, autophagy level was increased, proliferation, migration, invasion cells were inhibited. m6A methylated reader IGF2BP3 enhanced...
Abstract N 6 -methyladenosine (m A) modification is widespread in messenger RNAs and increasing evidence suggests the crucial roles of m A cell differentiation tissue development. However, whether modulates osteogenic mesenchymal stem cells (MSCs) has not been fully elucidated. Here we show that conditional knockout demethylase Alkbh5 bone marrow MSCs strengthened mass mice. Loss- gain-of-function studies demonstrated ALKBH5 negatively regulates vitro. At a mechanistic level, meRIP-seq...
N6-methyladenosine (m6A) is the most prevalent internal modification present in mRNAs of all higher eukaryotes. However, role m6A methylomes rice still poorly understood. With development MeRIP-seq technique, in-depth identification with has become feasible. A study suggested that crucial for posttranscriptional regulation related to Cd2+-induced malignant transformation, but association between plants and Cd tolerance not been reported. We investigated roots a cadmium (Cd)-treated group...
Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Previous studies identified several N6-methyladenosine (m6A)-related genes that play key roles in the initiation and progression of HCC patients. In particular, RNA methylation regulator ZC3H13 could be a candidate as novel biomarker therapeutic target hepatocellular carcinoma. HCC, low expression was reported, but molecular reason unclear. this study, we performed pan cancer analysis prognosis using The Cancer Genome Atlas...
Abstract It has been shown that N6‐methyladenosine (m6A) modification is involved in the development of complex human diseases, especially cancer. Our research investigated role and mechanism m6A lncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) Laryngeal squamous cell carcinoma (LSCC) progression. Microarray analysis was used to quantitatively detect apparent transcriptional level LSCC tissue. Methylated RNA immunoprecipitation‐qPCR (MeRIP‐qPCR), situ hybridization (ISH) quantitative...
Abstract Internal N 6 -methyladenosine (m A) modifications are among the most abundant of messenger RNA, playing a critical role in diverse biological and pathological processes. However, functional regulatory mechanism m A immune response to Mycobacterium tuberculosis infection remains unknown. Here, we report that methyltransferase-like 14 (METTL14)-dependent methylation NAPDH oxidase 2 ( Nox2 ) mRNA was crucial for host defense against M. -secreted antigen EsxB (Rv3874) inhibited...
Abstract Objective This study aims to evaluate the clinical efficacy of endoscopic plantar fascia release through modified dual medial deep approach for treatment refractory fasciitis. Methods A retrospective was conducted involving 34 patients with fasciitis treated by approach. Among them, 25 had concurrent calcaneal spurs. All were followed a minimum 12 months. Functional outcomes assessed using Visual Analogue Scale (VAS) and American Orthopaedic Foot Ankle Society (AOFAS) score, while...
Several studies have indicated a potential association between gut microbiota and bone density. However, the causal relationship mineral density across different age groups, as well role of inflammatory proteins mediators, remains unclear. Gut microbiota, proteins, (BMD) were identified in various groups using summary data from large-scale genome-wide studies. Mendelian randomization was employed to examine connections BMD primarily utilizing inverse variance weighted statistical method....
Abstract Background RNA methylation is a crucial in many biological functions, and its aberrant regulation associated with cancer progression. N6-Methyladenosine (m6A), 5-Methylcytosine (m5C), N1-methyladenosine (m1A) are common modifications of methylation. However, the effect m6A/m5C/m1A hepatocellular carcinoma (HCC) remains unclear. Method The transcriptome datasets, clinic information, mutational data 48 regulator genes were acquired from TCGA database, prognostic hazard model was...
Y-box binding protein 1 (YBX1) is involved in the multi-tumor occurrence and development. However, regulation of YBX1 lung tumorigenesis underlying mechanisms, especially its relationship with CDC25a, was remains unclear. In this study, we analyzed expression clinical significance CDC25a adenocarcinoma identified their roles cancer growth. The retrospective analysis 116 patients indicated that positively correlated expression. Cox-regression showed only high-ranking TNM stage low were an...
Despite decades of study into aortic dissection (AD), a lethal cardiovascular emergency due to tear in the aorta intima or bleeding within wall, leading separation different layers it, factors that influence its progression and deeper regulatory mechanisms remain poorly understood. Nowadays, with maturity N6-methyladenosine (m6A) sequence technology, m6A modification, one type RNA epigenesis, has gradually become new research hotspot for epigenetic molecular regulation. Especially recently,...
Mesenchymal stem cells (MSCs) possess strong immunoregulatory functions, one aspect of which is recruiting monocytes from peripheral vessels to local tissue by secreting monocyte chemoattractant protein 1 (MCP1). However, the regulatory mechanisms MCP1 secretion in MSCs are still unclear. Recently, N6-methyladenosine (m6A) modification was reported be involved functional regulation MSCs. In this study, we demonstrated that methyltransferase-like 16 (METTL16) negatively regulated expression...
Abstract Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a pivotal role in the pathogenesis and treatment bone‐related conditions such as osteoporosis bone regeneration. While WW domain‐containing coiled‐coil adaptor (WAC) protein is primarily associated with transcriptional regulation autophagy, its involvement MSC osteogenesis remains unclear. Here, data reveal that levels WAC are diminished both patients mouse models. It function facilitating enhancing new formation...
Abstract Background This study aims to investigate the expression of UBQLN1 in lung cancer (LC) tissue and diagnostic capability autoantibody (anti-UBQLN1) detection LC discrimination pulmonary nodules (PNs). Methods Sera from 798 participants were used discover validate level autoantibodies via HuProt microarray Enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was applied establish model. Receiver operating characteristic curve (ROC) performed evaluate potential....
Abstract Background: Laryngeal cancer has the highest mortality rate among head and neck tumours. RNA N6-methyladenosine (m6A) is most plentiful variable in mammalian mRNA. Yet, m6A regulatory mechanism underlying carcinogenesis or progression of LSCC remains poorly understood. Methods: The methylation quantification kit was used to detect tissue levels. microarray analysis, mRNA transcriptomic sequencing (mRNA-seq), proteomics were determine RBM15, TMBIM6, IGF2BP3. Immunohistochemical...
<abstract> <p>Since multiple studies have reported that small nucleolar RNAs (snoRNAs) can be serve as prognostic biomarkers for cancers, however, the values of snoRNAs in lung adenocarcinoma (LUAD) remain unclear. Therefore, main work this study is to identify LUAD and conduct a comprehensive analysis. The Cancer Genome Atlas cohort whole-genome RNA-sequencing dataset included study, analysis bioinformatics approaches are used identification snoRNAs. There were seven screened...
RNA modification, including m6A, m5C, m1A, and m7G, participated in tumor progress. Therefore, the purpose of present study was to explore role m6A/m5C/m1A/m7G regulatory genes prognosis microenvironment (TME) for hepatocellular carcinoma (HCC).71 expression HCC detected, differentially expressed were screened, molecular forms classified by unsupervised consensus clustering. Cox regression Least Absolute Shrinkage Selection Operator (LASSO) analysis applied establish a prognostic signature....