A5079519560- Genomics, phytochemicals, and oxidative stress
- Helicobacter pylori-related gastroenterology studies
- Protein Degradation and Inhibitors
- Antioxidant Activity and Oxidative Stress
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Circadian rhythm and melatonin
- Carcinogens and Genotoxicity Assessment
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Advanced Glycation End Products research
- Medical and Biological Sciences
- Pharmaceutical industry and healthcare
- Bioactive Compounds and Antitumor Agents
- Ferrocene Chemistry and Applications
- Liver physiology and pathology
- Liver Disease and Transplantation
- Medicinal plant effects and applications
- Phytochemistry and Bioactive Compounds
- Chronic Kidney Disease and Diabetes
- Chromatin Remodeling and Cancer
- Economic and Financial Impacts of Cancer
Dalian Medical University
2014-2025
Second Affiliated Hospital of Dalian Medical University
2016-2025
Shandong University of Technology
2024
China Three Gorges University
2023-2024
Jianghan University
2023
Liaoning University
2021
Shanghai University of Traditional Chinese Medicine
2018-2020
First Affiliated Hospital of Dalian Medical University
2014-2018
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2018
Shanghai East Hospital
2016
// Jian-Jun Lu 1, * , Lingyi Fu 2, 3, Zhipeng Tang 4, Changlin Zhang 2 Lijun Qin 5 Jingshu Wang Zhenlong Yu 4 Dingbo Shi Xiangsheng Xiao Fangyun Xie Wenlin Huang 6 Wuguo Deng 1 Department of Thoracic Surgery, The First Affiliated Hospital, Yat-sen University, Guangzhou, China Sun University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, 3 Guangdong General Academy Medical Sciences, Institute Stem Cell, Dalian Dalian, Pediatrics,...
// Meng Dai 1, * , Jian-Jun Lu 3, Wei Guo 1 Wendan Yu Qimin Wang 4 Ranran Tang Zhipeng Yao Xiao Zhenglin Li Sun Xiuna Qin Wenlin Huang 2, 5 Wu-guo Deng Taihua Wu The First Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Central Hospital, Medical University, Dalian, China 2 Yat-Sen University Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, 3 Department Thoracic Surgery, Yat-sen Second Targeted Drug for Tumors Guangdong...
Bromodomain PHD finger transcription factor (BPTF), a core subunit of nucleosome-remodeling (NURF) complex, plays an important role in chromatin remodeling. However, its precise function and molecular mechanism involved hepatocellular carcinoma (HCC) growth are still poorly defined. Here, we demonstrated the tumor-promoting BPTF HCC progression. was highly expressed cells tumor tissues patients compared with normal liver tissues. Knockdown inhibited cell proliferation, colony formation stem...
Cyclooxygenase‐2 (COX‐2) is highly expressed in tumor cells and has been regarded as a hallmarker for cancers, but the excise regulatory mechanism of COX‐2 tumorigenesis remains largely unknown. Here, we pulled down identified novel regulator, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1), which could specifically bind to core promoter regulate growth non‐small‐cell lung cancers (NSCLCs). Knockdown hnRNPA2/B1 by shRNA or siRNA downregulated expression prostaglandin E2 (PGE2)...
Y-box binding protein 1 (YBX1) is involved in the multi-tumor occurrence and development. However, regulation of YBX1 lung tumorigenesis underlying mechanisms, especially its relationship with CDC25a, was remains unclear. In this study, we analyzed expression clinical significance CDC25a adenocarcinoma identified their roles cancer growth. The retrospective analysis 116 patients indicated that positively correlated expression. Cox-regression showed only high-ranking TNM stage low were an...
Eukaryotic translation initiation factor 4 gamma 1(EIF4G1) is related to tumorigenesis and tumor progression. However, its role the underlying mechanisms in regulation of development non-small cell lung cancers (NSCLC) remain largely unknown. Here we report that levels EIF4G1 expression are much higher NSCLC lines tissues than those normal cells adjacent from same patients. Using shRNA knock down stably, found required for proliferation, anchorage-independent growth, migration invasion....
To investigate the protective effects of Ampelopsis grossedentata (AMP) on dextran sulfate sodium (DSS)-induced colitis in mice based systems pharmacology approach.Systems approach was used to predict active ingredients, candidate targets and efficacy AMP ulcerative (UC) using a holistic process compound screening, target fishing, network construction analysis. A DSS-induced model C57BL/6 (n = 10/group) constructed treated with 5-aminosalicylic acid (100 mg/kg/d) (400 confirm underlying...
Acrolein is a ubiquitous environmental pollutant that produced by the incomplete combustion of cigarette smoke, forest fires, petroleum fuels, plastic materials, and cooking fumes. Inhalation common form people exposure to acrolein, increasing evidence demonstrates acrolein impairs cardiovascular system targeting vascular endothelial cells. However, molecular mechanism cytotoxicity on cells remains unclear. This work focused toxicity human umbilical vein (HUVECs). The was studied based...
To investigate the effect of metformin on gut microbiota imbalance in patients with type 2 diabetes mellitus (T2DM), and value probiotic supplementation.
// Wei Guo 1,* , Jianjun Lu 3,* Meng Dai 1 Taihua Wu Zhenlong Yu Jingshu Wang 2 Wangbing Chen Dingbo Shi Wendan Yao Xiao Canhui Yi Zhipeng Tang Tingting Xu Xiangsheng Yuhui Yuan Quentin Liu 1,2 Guangwei Du 4 and Wuguo Deng Institute of Cancer Stem Cell & First Affiliated Hospital, Dalian Medical University, Dalian, China Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China; Colaborative Innovation Center Medicine, Guangzhou, 3 Department...
A previous study by our group indicted that overexpression of bromodomain PHD-finger transcription factor (BPTF) occurs in lung adenocarcinoma, and is closely associated with advanced clinical stage, higher numbers metastatic lymph nodes, the occurrence distant metastasis, low histological grade, poor prognosis. Down-regulation BPTF inhibited adenocarcinoma cell proliferation promoted apoptosis. The purpose this to identify valuable microRNAs (miRNAs) target modulate proliferation. In...
Schisandra chinensis fruit has been shown to restore carbohydrate‐ and lipid‐metabolic disorders anti‐hepatotoxicity anti‐hepatitis activities. However, the molecular targets mediating pharmacological properties of S . have not clarified. Here, we assayed effects ethanol extract (SCE) on farnesoid X receptor (FXR) transactivity. The SCE (1 g/100 g diet) were assessed in high‐fat diet (HFD)‐fed C57BL/6 mice ob/ob mice. FXR Fgf15 signalling pathways evaluated by silencing, ELISA, Western blot...
Methylglyoxal (MGO) is a reactive carbonyl species that can cause cellular damage and closely related to kidney disease, especially diabetic nephropathy. The toxic effect of MGO (0.5, 1, 2 mM) on human embryonic (HEK293) cells its underlying mechanisms were explored in this study. Cell viability, apoptosis the signaling pathways measured with MTT, fluorescent staining western blot experiments, results showed could induce oxidative stress cell inflammation, level oxygen (ROS) increased,...
Rechargeable lithium–oxygen (Li–O2) batteries are known for their ultrahigh theoretical energy density among chemical batteries. However, the low catalytic activity and poor stability of cathode catalyst root issues limiting practical applications. In this work, a design strategy to enhance TiC material was devised by C surface modification. The carbon-coated core–shell TiC@C nanomaterial designed, which combined good electrical conductivity carbon materials with excellent catalysis TiC....
Alcoholic fatty liver disease (AFLD) is a illness resulting from excessive alcohol consumption. Esculentoside A (EsA) possesses various properties, including antioxidative and anti-inflammatory capabilities, but its role mechanism in AFLD have remained unclear. In this study, we aimed to elucidate the functions of EsA AFLD. We utilized ethyl alcohol-induced Alpha Mouse 12 (AML-12) cells as model mimic conditions. Cell viability was evaluated utilizing Counting Kit-8 assay. Lipid accumulation...