A5075731033- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Antimicrobial Peptides and Activities
- Adipose Tissue and Metabolism
- Clostridium difficile and Clostridium perfringens research
- Birth, Development, and Health
- Influenza Virus Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease and Transplantation
- Neurological Disease Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Diet, Metabolism, and Disease
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- Ga2O3 and related materials
- Peroxisome Proliferator-Activated Receptors
- Electrocatalysts for Energy Conversion
- Medicinal Plants and Bioactive Compounds
- Alzheimer's disease research and treatments
- COVID-19 epidemiological studies
- Advanced Photocatalysis Techniques
Peking University
2015-2025
Peking University Third Hospital
2015-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Beijing Technology and Business University
2020-2024
Sichuan University
2017-2024
Yantaishan Hospital
2024
Beijing Tian Tan Hospital
2024
Capital Medical University
2024
Southwest University
2024
Soochow University
2008-2023
The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression. Mitochondrial changes are critical for the response stress. However, transcriptional non-transcriptional mechanisms which HIF-1α regulates mitochondria in poorly understood. Here, we examined subcellular localization human cells identified a small fraction that translocated after exposure or H2O2 treatment. Moreover, livers...
Silver nanoparticles (AgNPs) are widely used for manufacturing products containing antibacterial agents, as well food technologies such edible films and packaging. Routes of AgNPs exposure principally derived by contacting with certain medical sprays, food, toothpaste, purification products. Previously, we showed that induce endoplasmic reticulum (ER) stress promote apoptosis progression in SH-SY5Y cells; however, whether AgNP-induced ER is able to trigger autophagy vivo vitro, the role...
Disrupted myelin and impaired repair have been observed in the brains of patients various mouse models Alzheimer's disease (AD). Clemastine, an H1-antihistamine, shows capability to induce oligodendrocyte precursor cell (OPC) differentiation formation under different neuropathological conditions featuring demyelination via antagonism M1 muscarinic receptor. In this study, we investigated if aged APPSwe/PS1dE9 mice, a model AD, can benefit from chronic clemastine treatment. We found treatment...
Abstract Alcohol exposure during central nervous system (CNS) development can lead to fetal alcohol spectrum disorder (FASD). Human imaging studies have revealed significant white matter (WM) abnormalities linked cognitive impairment in children with FASD; however, the underlying mechanisms remain unknown. Here, we evaluated both acute and long‐term impacts of on oligodendrocyte number WM integrity a third trimester‐equivalent mouse model FASD, which pups were exposed first 2 weeks postnatal...
The autoregenerative redox PEG-PLGA coating CeO<sub>2</sub> nanoparticles can effectively protect lens epithelial cells from oxidative stress and restrain α-crystallin glycation crosslinking, thereby alleviating diabetic cataracts.
Influenza A virus (IAV) is a significant zoonotic pathogen that poses considerable challenge to public health due its continuous mutations. Lipid droplets (LDs) have been shown play an important role in the process of several viral infections. However, their IAV infection remains unclear. Here, we found altered lipid metabolism and increased content LDs lungs mice. In vitro, also mediated formation A549 cells. Besides, inhibition can significantly suppress replication release inflammatory...
Anthracyclines, such as doxorubicin (DOX), are among the effective chemotherapeutic drugs for various malignancies. However, their clinical use is limited by irreversible cardiotoxicity. This study sought to determine role of neuraminidase 1 (NEU1) in DOX-induced cardiomyopathy and potential cardio-protective effects NEU1 inhibitor oseltamivir (OSE). Male Sprague-Dawley (SD) rats were randomized into three groups: control, DOX, DOX + OSE. was highly expressed DOX-treated rat heart tissues...
Abstract Pneumonia is the most common complication of varicella infections. Although previous studies have tended to focus mainly on immunocompromised patients, pneumonia can also occur in healthy adults. Therefore, this study, we aimed assess progression immunocompetent hosts. This retrospective study involved adult outpatients with who attended Fever Emergency facility Peking University Third Hospital from April 1, 2020, October 31, 2022. Varicella was defined as a classic chickenpox-type...
The aim of the present study was to investigate protective effects melatonin (MLT) on hypertension-induced renal injury and identify its mechanism action. Twenty-four healthy male Wistar rats were divided into a sham control group (n=8), which subjected operation received vehicle treatment (physiological saline intraperitoneally at 0.1 ml/100 g), occlusion left artery treatment, MLT treated with (10 mg/kg/day). Pathological features tissues determined using hematoxylin eosin staining Masson...
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognition and memory, in which oxidative stress has been played crucial role the pathology AD. Electroacupuncture (EA) widely used therapy based on traditional acupuncture combined with modern electrotherapy Asia. The present study aimed to determine effects EA treatment spatial learning memory impairment, elucidate status NOX2-related rat model induced Beta-amyloid1-42 (Aβ1-42)....
To explore the effect of acacetin on subarachnoid hemorrhage (SAH) and its possible mechanism.
Donation after cardiac death (DCD) kidneys suffer a high incidence of delayed graft function attributable to warm ischemia and cold (CI). Neither the mechanism injury nor type cell has been described. Clinical studies suggest that perfusion storage (PS) DCD may reduce although protection is unknown. In porcine model DCD, we hypothesized have increased caspase-1 due (WI) caspase-3 apoptosis CI.Male Yorkshire pigs subjected were perfused with University Wisconsin solution. The removed stored...
Drought is the one of most important environment stresses that restricts crop yield worldwide. Cassava (Manihot esculenta Crantz) an food and energy has many desirable traits such as drought, heat low nutrients tolerance. However, mechanisms underlying drought tolerance in cassava are unclear. Ethylene signaling pathway, from upstream receptors to downstream transcription factors, plays roles environmental stress responses during plant growth development. In this study, we used...