A5046973215- Cytokine Signaling Pathways and Interactions
- Plant Stress Responses and Tolerance
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Environmental Toxicology and Ecotoxicology
- Computational Drug Discovery Methods
- Ecology and Vegetation Dynamics Studies
- Advanced biosensing and bioanalysis techniques
- Plant and animal studies
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- PI3K/AKT/mTOR signaling in cancer
- Aluminum toxicity and tolerance in plants and animals
- Synthesis and Characterization of Pyrroles
- Military Defense Systems Analysis
- Cancer Mechanisms and Therapy
- Pharmacogenetics and Drug Metabolism
- Liver physiology and pathology
- Medicinal Plant Pharmacodynamics Research
- Animal Ecology and Behavior Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Polymer-Based Agricultural Enhancements
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
Guangzhou Medical University
2025
Fujian Agriculture and Forestry University
2024
Chinese PLA General Hospital
2024
Ocean University of China
2013-2024
Center for Excellence in Brain Science and Intelligence Technology
2024
Harbin Normal University
2024
Lanzhou University
2011-2023
Ministry of Agriculture and Rural Affairs
2023
Soochow University
2017-2022
Huazhong University of Science and Technology
2021
Epidermal growth factor receptor (EGFR) is a clinical therapeutic target to treat subset of non-small cell lung cancer (NSCLC) harboring EGFR mutants. However, some patients with similar kind mutation show intrinsic resistance tyrosine kinase inhibitors (TKI). It indicates that other key molecules are involved in the survival these cells. We showed here 2-[(aminocarbonyl)amino]-5 -(4-fluorophenyl)-3- thiophenecarboxamide (TPCA-1), previously reported inhibitor IκB kinases (IKK), blocked...
The miR-294 and miR-302 microRNAs promote the abbreviated G1 phase of embryonic stem cell (ESC) cycle suppress differentiation induced by let-7. Here, we evaluated role retinoblastoma (Rb) family proteins in these settings. Under normal growth conditions, promoted rapid G1-S transition independent Rb family. In contrast, suppressed further accumulation cells response to nutrient deprivation cell-cell contact an Rb-dependent fashion. We uncovered five additional miRNAs (miR-26a, miR-99b,...
Atherosclerosis is a chronic vascular disease posing great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities inhibit lipid accumulation and polarization conversion of macrophages then attenuate atherosclerotic lesions.All male Apolipoprotein E-deficient (ApoE-/-) mice were fed high-fat diet supplemented with RVS (10 mg/kg/day) or the same volume normal saline gavage for 20 weeks. The burden plaques in determined by histopathological staining....
Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates essential processes cell survival, growth and proliferation many types tumors, as well immune diseases. By establishing a STAT3 based high-throughput drug screening system lung cancer A549 cells, we have screened library from natural...
Many community experiments have shown a positive relationship between plant biodiversity and productivity, with measured in multiple ways based on taxonomy, function, phylogeny. Whether these different measures of their interactions explain variation productivity natural assemblages has rarely been tested. In removal experiment using alpine the Tibetan Plateau, we manipulated species richness functional diversity to examine how predict aboveground biomass production. We combined (functional,...
RNA interference (RNAi) technology has shown great promise for the treatment of cancer and other genetic disorders. Despite efforts to increase target tissue distribution, safe effective delivery siRNA diseased cells with sufficient cytosolic transport is another critical factor successful RNAi clinical application. Here, constructed lipid-based liquid crystalline nanoparticles, called nano-Transformers, can transform thestructure in intracellular acidic environment perform high-efficient...
Marine natural product (MNP) pretrichodermamide B (Pre B, 9) was identified as a novel STAT3 inhibitor in our previous work, while its metabolic instability hindered further development. To address this drawback, ligand structure-based drug design adopted leading to series of Pre derivatives. Among them, MNP trichodermamide (tri 24) obtained by skeletal rearrangement exhibited more potent antiproliferative activity with an IC50 value 0.12 μM against HCT116. Notably, 24 stood out improved...
Although thousands of genes have been identified or cloned in rice (Oryza sativa) the last two decades, majority them only separately characterized specific varieties single-gene modified backgrounds, thus limiting their practical application. We developed an optimized multiplex genome editing (MGE) toolbox that can efficiently assemble and stably express up to twelve sgRNA targets a single plant expression vector. In this study, we established MGE-based Rapid Directional Improvement (MRDI)...
Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings. Previous genome-wide association studies (GWASs) have identified many loci associated with neuroblastoma susceptibility; however, their application risk prediction for Chinese not been systematically explored. This study seeks to enhance by validating these evaluating performance polygenic models. We validated 35 GWAS-identified susceptibility a cohort of children, consisting 402...
Anthracyclines, such as doxorubicin (DOX), are among the effective chemotherapeutic drugs for various malignancies. However, their clinical use is limited by irreversible cardiotoxicity. This study sought to determine role of neuraminidase 1 (NEU1) in DOX-induced cardiomyopathy and potential cardio-protective effects NEU1 inhibitor oseltamivir (OSE). Male Sprague-Dawley (SD) rats were randomized into three groups: control, DOX, DOX + OSE. was highly expressed DOX-treated rat heart tissues...
Decabromodiphenyl ether (BDE-209), a new kind of persistent organic pollutants, was selected to investigate its influence on population growth and inter-specific competition between two species marine bloom-forming microalgae, Heterosigma akashiwo Karenia mikimotoi. (1)BDE-209 showed acute toxic effects both microalgae H. more sensitive from view 96 h-EC50 the ultrastructure variation. (2)The microalgal patterns in mono-culture were density-dependent normal co-culture significantly depressed...
Community assembly is a dynamic progression that reflects the interaction of several processes functioning at multiple scales. Understanding how these work in communities different successional stages important for identifying when regional or local are more community assembly, and developing effective preservation restoration strategies. We examined using chronosequence sub‐alpine meadows Qinghai‐Tibetan Plateau range from ‘natural’ (never farmed), to those have been protected agricultural...
Recurrent liver cancer after surgery is often treated with radiotherapy, which induces damage. It has been documented that activation of the TGF-β and NF-κB signaling pathways plays important roles in irradiation-induced pathologies. However, significance mTOR remains undefined irradiation exposure. In present study, we investigated effects inhibiting mTORC1 on irradiated livers. Male C57BL/6J mice were acutely exposed to 8.0 Gy X-ray total body subsequently rapamycin. The rapamycin...
Janus kinase (JAK) 2 plays a pivotal role in the tumorigenesis of signal transducers and activators transcription (STAT) 3 constitutively activated solid tumors. JAK2 mutations are involved pathogenesis various types hematopoietic disorders, such as myeloproliferative polycythemia vera, essential thrombocythemia, primary myelofibrosis. Thus, small-molecular inhibitors targeting potent for therapy these diseases. In this study, we screened 1,062,608 drug-like molecules from ZINC database 2080...
The objective of this article is to study the etiology community-acquired pneumonia in children with airway malacia.We retrospectively reviewed medical records 428 patients. All patients underwent bronchoscopy, and bronchoalveolar lavage samples were processed for microbiological assessment.In a total cases reviewed, 60 found have malacia. Pathogens identified 44 specimens (73.3%), 32 being single-pathogen infections. most common pathogen was respiratory syncytial virus (RSV; 20%)....
An efficient transformation method is lacking for most non-model plant species to test gene function. Therefore, subcellular localization of proteins interest from plants mainly carried out through transient in homologous cells or heterologous model such as Arabidopsis. Although analysis expression patterns organisms like yeast and Arabidopsis can provide important clues about protein localization, these systems may not always faithfully reflect the native distribution other species. On...
A novel, one-pot single step method for the preparation of 2,4-diarylpyrroles from α-halo oxime ethers has been developed, which is mediated by ytterbium.
Observational investigations have examined the impact of glucosamine use on risk cancer and non-neoplastic diseases. However, findings from these studies face limitations arising confounding variables, reverse causation, conflicting reports. Consequently, establishment a causal relationship between habitual consumption diseases necessitates further investigation.