A5001880663- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- Biosensors and Analytical Detection
- interferon and immune responses
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Gold and Silver Nanoparticles Synthesis and Applications
- Ginseng Biological Effects and Applications
- Electrochemical Analysis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Genomics and Chromatin Dynamics
- Advanced Biosensing Techniques and Applications
- Analytical Chemistry and Sensors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nuclear Structure and Function
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Luminescence and Fluorescent Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Environmental Toxicology and Ecotoxicology
University of California, Davis
2025
Lanzhou University
2013-2023
Tsinghua University
2019-2023
Beijing Tian Tan Hospital
2022
Capital Medical University
2022
Ministry of Education of the People's Republic of China
2021
Cleveland Clinic
2016-2020
Institute of Catalysis and Petrochemistry
2020
Biocat
2020
Henan Provincial People's Hospital
2020
Trace detection of the conformational transition beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how novel nanofluidic biosensor using controlled, reproducible surface enhanced Raman spectroscopy active site was developed observe Abeta different states during self-assembly process as well distinguish confounder proteins commonly found cerebral spinal fluid.
Significance We describe unexpected cooperation between two cytokines that are important in regulating the growth of cancers, namely, type I interferons (IFNs) and interleukin 6 (IL6). It is well established IL6 vital for ability many tumor types to prosper, work current paper reveals signaling pathway driven by IFN, which also evident increases expression through a direct effect on gene. The findings may help identify new antitumor targets therapy.
Acetaminophen is found in numerous water samples worldwide, such as drinking and pond water. Nearly half of the drug-induced acute liver failure cases are related to acetaminophen. Herein, by engineering a novel nonspherical polydopamine@zeolitic imidazolate framework-67 (PDA@ZIF-67) template, facile effective strategy including pyrolysis subsequent oxidation proposed build Co/Co3O4 nanoparticles (NPs) coupled with hollow nanoporous carbon polyhedrons (Co/Co3O4@HNCP). Then, highly sensitive...
Abstract Cardiovascular diseases (CVDs) continue to drive global mortality rates, underscoring an urgent need for advancements in healthcare solutions. The development of point‐of‐care (POC) devices that provide rapid diagnostic services near patients has garnered substantial attention, especially as traditional systems face challenges such delayed diagnoses, inadequate care, and rising medical costs. advancement machine learning techniques sparked considerable interest research engineering,...
We have developed an optofluidic device that improves the sensitivity of surface enhanced Raman spectroscopy (SERS) when compared to other SERS approaches. This has a pinched and step microchannel-nanochannel junction can trap assemble nanoparticles/target molecules into optically active clusters by using capillary force. These provide electromagnetic enhancement factor approximately 10(8). In addition, due continuous flow transport sites, numbers sites are increased. As result, detection...
Epidermal growth factor receptor (EGFR) is a clinical therapeutic target to treat subset of non-small cell lung cancer (NSCLC) harboring EGFR mutants. However, some patients with similar kind mutation show intrinsic resistance tyrosine kinase inhibitors (TKI). It indicates that other key molecules are involved in the survival these cells. We showed here 2-[(aminocarbonyl)amino]-5 -(4-fluorophenyl)-3- thiophenecarboxamide (TPCA-1), previously reported inhibitor IκB kinases (IKK), blocked...
Recent advances have revealed the essential role of gut microbiomes in therapeutic efficiency immune checkpoint inhibitors (ICIs). Inspired by biostimulation, a method using nutrients to accelerate growth soil microorganisms and recovery microbial consortia, here we propose bilberry anthocyanin combo containing chitosan low molecular citrus pectin (LCP), which LCP–chitosan is used encapsulate anthocyanins so enhance its digestive stability and, moreover, modulate microbiome more favorable...
Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates essential processes cell survival, growth and proliferation many types tumors, as well immune diseases. By establishing a STAT3 based high-throughput drug screening system lung cancer A549 cells, we have screened library from natural...
Carbon dots with different emission fluorescence have a great number of potential applications for various areas from in vitro imaging and biotherapy, due to the good biosafety red fluorescent CDs, efficient ion detection photocatalysis, excellent photoluminescence properties blue carbon dots. Traditional methods synthesis full-spectrum require 24 h complex column chromatography. In this paper, facile microfluidic method continuously synthesize small uniform is developed first time. The...
Type I interferons (IFN-I) protect us from viral infections. Signal transducer and activator of transcription 2 (STAT2) is a key component interferon-stimulated gene factor 3 (ISGF3), which drives expression in response to IFN-I. Using electron microscopy, we found that, naive cells, U-STAT2, lacking the activating tyrosine phosphorylation, forms heterodimer with U-STAT1 an inactive, anti-parallel conformation. A novel phosphorylation STAT2 on T404 promotes IFN-I signaling by disrupting...
We have fabricated silica nanochannels with inner diameter as small 20nm using a scanned coaxial electrospinning and demonstrated their application for single molecule detection. A jet, the use of motor oil core sol-gel solution shell, is extruded through source deposited on rotating collector oriented nanofibers. They are then annealed to cross-link eliminate oil, thereby forming nanochannels. Subsequently, fluorescent dye was injected into individual via capillary force detection performed...
Bilberry anthocyanin extracts change the gut microbiota and enhance anti-tumor efficiency of PD-L1 antibody.
In cancer cells, endogenous or therapy-induced DNA damage leads to the abnormal presence of in cytoplasm, which triggers activation cGAS (cyclic GMP–AMP synthase) and STING (stimulator interferon genes). STAT2 suppresses cGAMP-induced expression IRF3-dependent genes by binding STING, blocking its intracellular trafficking, is essential for full response activation. reshapes signaling inhibiting induction IRF3-dependent, but not NF-κB–dependent genes. This noncanonical activity regulated...
The discovery that gut microbiota profoundly influences the efficiency of immune checkpoint blockade therapy in patients inspired efforts to enhance cancer treatment using live microorganisms modify microbiome. Here we present a new idea modifying anti-PD-L1 efficiency, is, natural nutrients. In this work, demonstrate mouse MC38 colon tumor model and jujube, most frequently used adjuvant drug traditional Chinese medicine, as nutrient. enhancing effects jujube components were examined, well...
Activation of transcription factor STAT3 is involved in cell proliferation, differentiation, and survival. Constitutive activation pathway has been associated with the oncogenesis various types cancers. It reported that plays a key role G1 to S phase cycle transition induced by cytokine receptor subunit gp130, through upregulation cyclins D1, D2, D3, A, Cdc25A concomitant downregulation p21 p27. However, its mediating G2-M not studied. The cyclin B1/Cdc2 complex widely accepted as trigger...
Tamoxifen, a widely used modulator of the estrogen receptor (ER), targets ER-positive breast cancer preferentially. We powerful validation-based insertion mutagenesis method to find that expression dominant-negative, truncated form histone deacetylase ZIP led resistance tamoxifen. Consistently, increased full-length gives opposite phenotype, inhibiting genes whose products mediate resistance. An important example is JAK2 . By binding two specific sequences in promoter, suppresses expression....
A new class of noble metal-organic hybrid chiral complex nanoparticles with large optical activity was facilely fabricated via self-assembly, and explored for highly sensitive selective sensing Hg(2+) without the need any separation purification.
Abstract Background While anthocyanins are proven to be effective in inhibiting tumour cell proliferation, the underlying mechanisms remain unclear. This research aims explore glycosylation of inhibitory effects and potential mechanism. Methods The effect on mouse colon cancer cells (MC38) was examined by MTT flow cytometric analyses. pathway anthocyanin explored assessment mitochondrial membrane (MMP), caspase-3 caspase-9 activity, as well energy metabolism terms glucose uptake, NAD + /NADH...
Cancer vaccines have gained widespread attention in recent years as an emerging treatment for tumors. However, most therapeutic cancer failed phase III clinical trials due to faint benefits. In this study, we funded that a specific synbiotic composing Lactobacillus rhamnosus GG (LGG) and jujube powder significantly enhanced the effects of whole cells vaccine MC38 bearing-mouse. The utilization LGG increased abundance Muribaculaceae , which is conductive anti-tumor effect, but reduced...
Whereas dietary intervention with natural nutrients plays an important role in activating the immune response and holds unprecedented application potential, underpinning mechanism is poorly understood. The present work was dedicated to comprehensively examine effects of ultrafine jujube powder (JP) on gut microbiota and, consequentially, associated rate anti-PD-L1 treatment against murine colon adenocarcinoma. A adenocarcinoma model immunotherapy established evaluate how interventions affect...