We have used a nonlithographic deposition process to form single polymeric nanowire chemical sensors. Oriented polyaniline nanowires, with diameters on the order of 100 nm, were deposited gold electrodes. The devices showed rapid and reversible resistance change upon exposure NH3 gas at concentrations as low 0.5 ppm. well-defined single-wire geometry allows for characterization wire material device response. response times sensors various correspond radius-dependent differences in diffusion...

We present a method for controlled deposition of oriented polymeric nanofibres. The uses microfabricated scanned tip as an electrospinning source. is dipped in polymer solution to gather droplet source material. A voltage applied the causes formation Taylor cone, and at sufficiently high voltages, jet extracted from droplet. By moving relative surface, acting counter-electrode, nanofibres can be deposited integrated with surface structures. For example, we fibres polyethylene oxide diameters...

A polymeric microfluidic chip made of Zeonor 1020 was fabricated using conventional embossing techniques to perform capillary electrophoresis for selected ion monitoring and reaction mass spectrometric detection small molecules. silicon master microfabricated photolithographic dry etching processes. The channel embossed in the plastic from a master. thermally bonded with cover form an enclosed channel. This (60-μm width, 20-μm depth, 2.0- 3.5-cm length) provided (CE) separation polar...

Trace detection of the conformational transition beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how novel nanofluidic biosensor using controlled, reproducible surface enhanced Raman spectroscopy active site was developed observe Abeta different states during self-assembly process as well distinguish confounder proteins commonly found cerebral spinal fluid.

ABSTRACT Silicon rubbers are widely used in a variety of products ranging from cooking utensils and electronics to medical devices implants. Recently, they have sparked an interest among soft robotics researchers as can be easily formed into various shapes actuated relatively fast easy way. In this article, we examine the nonlinear elastic response silicon rubber, Ecoflex, under both compressible incompressible constraints. An experimental test on uniaxial tension indicates slight...

A miniaturized wideband interferometry-based sensor for complex dielectric spectroscopy of liquid chemicals is presented in this paper. Two composite right-/left-hand (CRLH) transmission lines (TLs) are employed a direct downconversion architecture. The material under test (MUT) placed contact with the printed interdigital capacitor artificial TL as sensing component. Since CRLH provides nonlinear dispersion characteristics, improved sensitivity (4.2-8 GHz) operation achieved compared...

Per- and poly-fluoroalkyl substances (PFASs) are man-made chemicals that toxic widely detected in the environment, including drinking water sources. A cost-effective treatment process for PFASs is currently not available. We developed reusable hydrogel sorbents to remove long- short-chain perfluoroalkyl acids 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid (GenX), which emerging PFAS. Through fluoridation amination of poly(ethylene glycol) diacrylate (PEGDA), newly synthesized can...

We present a method for the formation of oriented polymeric nanofibers using electrospinning deposition from an integrated microfluidic device. The source includes microfabricated triangular shaped tip, at exit channel to form that can be brought close counter electrode and scanned over surface features. Using ability orient nanofiber deposition, we formed 140 nm diameter suspended etched trenches on silicon wafer, configuration allows electrical mechanical measurements deposited nanofibers.

We have developed an optofluidic device that improves the sensitivity of surface enhanced Raman spectroscopy (SERS) when compared to other SERS approaches. This has a pinched and step microchannel-nanochannel junction can trap assemble nanoparticles/target molecules into optically active clusters by using capillary force. These provide electromagnetic enhancement factor approximately 10(8). In addition, due continuous flow transport sites, numbers sites are increased. As result, detection...

We have developed an integrated microfluidic material processing chip and demonstrated the rapid production of collagen microspheres encapsulating cells with high uniformity cell viability. The three steps. Monodisperse microdroplets were generated at a T junction between aqueous mineral oil flows. flow was heated immediately to 37 °C initiate fiber assembly within gelation channel. Gelled extracted from phase into culture media extraction chamber. Collagen after microdroplet generation...

We have demonstrated a new electrospray ionization (ESI) device incorporating tip made from shaped thin film, bonded to microfluidic channel, and interfaced time-of-flight mass spectrometer (TOFMS). A triangular-shaped polymer was formed by lithography etching. 20 μm wide 10 deep, embossed in cyclo olefin substrate using silicon master. The triangular aligned with the channel between plate flat create wicking protruding end. This structure aided formation of stable Taylor cone at apex tip,...

We fabricated nanofluidic channels that have elliptical cross sections with major and minor radii of less than 100 nm, without the use electron-beam or other high-resolution lithography. The were formed by thermal removal sacrificial polymer nanofibers. template fiber was deposited on a target substrate electrospinning encapsulated spin-on glass. shape eliminates sharp corners, at which fluid flow is hindered, provides convenient boundary conditions for theoretical modeling in channels....

We have used scanned electrospinning to deposit oriented polyethylene oxide and silica glass fibres over trenches etched in silicon. measured the Young's moduli of using an atomic force microscope. The agree with values calculated from previously mechanical resonance frequencies similar fibres. are significantly larger than those reported for bulk films, suggesting molecular orientation

Microfluidic channels filled with liquid metal are used to realize miniature and reconfigurable CPW folded slot antennas. The method is based on employing the reactive loading effect of fluid bridges top antenna. As a result this loading, frequency antenna reduces miniaturized by factor 85%. Also, changing configuration empty channels, each channel can be as switch. By using two pairs microfluidic three different bands 2.4, 3.5, 5.8 GHz achieved. This translates switching ratio (f <sub...

We report on the fabrication of suspended silicon dioxide nanofibers using a scanned electrospinning source and calcination process. measured mechanical oscillations individual fibers, driven by piezoelectric actuator. The method was utilized to extrude polymeric from blended solution deposit oriented patterned surfaces form structures. deposited were converted oxide without changing their morphologies. By utilizing this technique, nanofiber with diameter 120 nm fabricated resonant frequency...

We describe the integration of a cyclo-olefin polymer based microchip with sheathless capillary tip for electrospray ionization-mass spectrometry (ESI-MS). The was fabricated by hot embossing and thermal bonding. Its design includes side channel adjusting composition solution so that analytes in 100% water can be analyzed. fused silica capillaries, used sample introduction, tips MS coupling were directly inserted into microchannel before bonding device. A microfabricated on-chip gold...

We have fabricated silica nanochannels with inner diameter as small 20nm using a scanned coaxial electrospinning and demonstrated their application for single molecule detection. A jet, the use of motor oil core sol-gel solution shell, is extruded through source deposited on rotating collector oriented nanofibers. They are then annealed to cross-link eliminate oil, thereby forming nanochannels. Subsequently, fluorescent dye was injected into individual via capillary force detection performed...

Extracellular vesicles (EVs) play an important role in intercellular communication. Recently, there has been increasing interest EVs as potential diagnostic biomarkers and therapeutic vehicles. However, the molecular properties cargo information of EV subpopulations have not yet fully investigated due to lack reliable reproducible separation technology. Current approaches faced difficulties with efficiently isolating from biofluids, especially small EVs. Here, we report isolation method...

In this paper, a microfluidically reconfigurable coplanar waveguide (CPW) filter is presented with tuning range of ~ 1.6:1 and four different states. The passband frequency the changed based on employing capacitive loading effect liquid metal placed top each CPW resonator using three parallel micro-channels. addition, because bridges, miniaturization by factor 40% achieved. digitally tuned from 3.4 to 5.5 GHz an insertion loss less than 5.0 dB relative bandwidth 5 ± 0.35%. RF power-handling...

For the hundreds of millions worldwide diabetic patients, glucose test strips are most important and commonly used tool for monitoring blood levels. Commercial use oxidases as recognition agents, which increases cost reduces durability strips. To lower sensors, we developed a paper-based electrical sensor with molecularly imprinted sites demonstrated determination various concentrations in bovine solutions. The sensing electrode is integrated molecular conductive polymer. A calibration graph...

A chip-based P450 in vitro metabolism assay coupled with ESI-MS and ESI-MS/MS detection is described this paper. The chips were made of a cyclic olefin polymer using hot embossing process. introduction reagent solutions into the chip was carried out fused-silica capillaries to two syringes flow rate controlled by syringe pump. Initial experiments here employed small commercial guard column an off-chip format desalt concentrate products enzymatic reaction prior analysis. system used both...