A5100371775- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Invertebrate Immune Response Mechanisms
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Microfluidic and Capillary Electrophoresis Applications
- T-cell and B-cell Immunology
- Pediatric health and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- Advanced Sensor and Energy Harvesting Materials
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Photonic and Optical Devices
- Asthma and respiratory diseases
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- Breast Lesions and Carcinomas
- S100 Proteins and Annexins
- Geoscience and Mining Technology
Cleveland Clinic Lerner College of Medicine
2014-2024
First Affiliated Hospital of Xinjiang Medical University
2023-2024
Xinjiang Medical University
2023-2024
Guangzhou Medical University
2024
Hebei University of Technology
2024
First Affiliated Hospital of Xiamen University
2023-2024
Southeast University
2023-2024
Hefei University of Technology
2024
Case Western Reserve University
2023-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Although IL-17 is emerging as an important cytokine in cancer promotion and progression, the underlining molecular mechanism remains unclear. Previous studies suggest that (IL-17A) sustains a chronic inflammatory microenvironment favors tumor formation. Here we report novel IL-17–mediated cascade via IL-17R–Act1–TRAF4–MEKK3–ERK5 positive circuit directly stimulates keratinocyte proliferation this axis dictates expression of target genes Steap4 (a metalloreductase for cell metabolism...
Abstract Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via induction of metalloreductase, STEAP4. IL-17-induced intracellular level leads activation an E3-ligase, XIAP, potentiates NFκB suppresses caspase 3 activity. Importantly, STEAP4-dependent is critical for colon tumor formation murine...
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in management GLM for many front-line surgeons medical specialists who care patients with disorders This consensus summarized to establish evidence-based recommendations GLM. Literature was reviewed using PubMed from January 1, 1971 July 31, 2020. Sixty-six international experienced multidisciplinary experts 11 countries or regions were invited review evidence. Levels...
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with release IL-1β. Here, we report a nonpyroptotic role full-length GSDMD in guiding IL-1β-containing small extracellular vesicles (sEVs) from intestinal epithelial cells (IECs). In response to caspase-8 inflammasome activation, GSDMD, chaperoned Cdc37/Hsp90, recruits E3 ligase, NEDD4, catalyze polyubiquitination pro-IL-1β, serving as signal for cargo...
Lrig1 marks a distinct population of stem cells restricted to the upper pilosebaceous unit in normal epidermis. Here we report that IL-17A–mediated activation EGFR plays critical role expansion and migration Lrig1+ their progenies response wounding, thereby promoting wound healing skin tumorigenesis. Lrig1-specific deletion IL-17R adaptor Act1 or mice impairs reduces tumor formation. Mechanistically, recruits for signaling cells. While TRAF4, enriched cells, tethers IL-17RA EGFR, c-Src...
NLRP3 inflammasome plays a critical spatiotemporal role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). This study reports mechanistic insight into noncanonical activation microglia for effector stage EAE. Microglia-specific deficiency ASC (apoptosis-associated speck-like protein containing C-terminal caspase-activation and recruitment [CARD] domain) attenuated T cell expansion neutrophil during EAE pathogenesis. Mechanistically, TLR stimulation led to...
Epidermal growth factor receptor (EGFR) is a clinical therapeutic target to treat subset of non-small cell lung cancer (NSCLC) harboring EGFR mutants. However, some patients with similar kind mutation show intrinsic resistance tyrosine kinase inhibitors (TKI). It indicates that other key molecules are involved in the survival these cells. We showed here 2-[(aminocarbonyl)amino]-5 -(4-fluorophenyl)-3- thiophenecarboxamide (TPCA-1), previously reported inhibitor IκB kinases (IKK), blocked...
A molecule from red berries blocks the activity of a proinflammatory cytokine and alleviates inflammation in mice.
Increasing evidence suggests that intratumoral inflammation has an outsized influence on antitumor immunity. Here, we report IL-17, a proinflammatory cytokine widely associated with poor prognosis in solid tumors, drives the therapeutic failure of anti-PD-L1. By timing deletion IL-17 signaling specifically cancer-associated fibroblasts (CAFs) late-stage show immune exclusion by activating collagen deposition program murine models cutaneous squamous cell carcinoma (cSCC). Ablation CAFs...
Stretchable electroluminescent devices represent an emerging optoelectronic technology for future wearables. However, their typical construction on sub-millimeter-thick elastomers has limited moisture permeability, leading to discomfort during long-term skin attachment. Although breathable textile displays may partially address this issue, they often have distinct visual appearances with discrete emissions from fibers or fiber junctions. This study introduces a convenient procedure create...
Abstract Strain monitoring is of great significance to the maintenance and safe operation engineering structures. To address shortcomings piezoelectric ceramics such as high inflexibility brittleness, in this study, polyvinylidene fluoride (PVDF) fibrous films were prepared by a efficient solution blow spinning technique. In case similar β -phase content, preparing efficiency PVDF fibers method increased about 8–10 times compared that electrospinning our previous work. The with average...
Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates essential processes cell survival, growth and proliferation many types tumors, as well immune diseases. By establishing a STAT3 based high-throughput drug screening system lung cancer A549 cells, we have screened library from natural...
Abstract This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of signaling in mice attenuated dextran sulfate sodium (DSS)-induced damage epithelium markedly reduced development an azoxymethane/DSS model colitis-associated cancer. A target gene, PLET1 (a progenitor cell marker involved wound healing), was highly induced DSS-treated tissues tumors IL-17RC–dependent manner. expression LGR5+ epithelial cells after DSS treatment....
IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is hallmark severe asthma and chronic obstructive pulmonary disease (COPD). Through RNA sequencing analysis transcriptomes human smooth muscle cells treated with IL-17A, dexamethasone (DEX, synthetic glucocorticoid drug), alone or combination, we identified group genes that are synergistically induced by DEX, including neutrophil-promoting cytokine CSF3. In type-17 (Th17/IL-17Ahi)...
Primary Sjögren’s Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due trial complications. This review addresses the absence of molecular-target-based approach therapy development highlights novel research on drug targets clinical trials. A literature search identified potential pSS treatment recent advances molecular...
Stretchable transparent electrodes are crucial components for deformable electronics. While solid-state struggle to achieve significant stretchability, liquid metal have emerged as a potential alternative. However, their widespread application has been limited by complex fabrication and reduced performance when stretched. This study introduces stretchable composed of in serpentine micromesh patterns. These constructed cost-effectively show high optical transmittance low sheet resistance....
The role of Mast cells has not been thoroughly explored in the context prostate cancer's (PCA) unpredictable prognosis and mixed immunotherapy outcomes. Our research aims to employs a comprehensive computational methodology evaluate cell marker gene signatures (MCMGS) derived from global cohort 1091 PCA patients. This approach is designed identify robust biomarker assist predicting responses immunotherapy.
The scavenger receptor-A (SR-A), originally recognized by its ability to internalize modified lipoproteins, has largely been studied in relation atherosclerosis as well innate immunity against pathogen infection. SR-A was recently shown be a receptor on antigen-presenting cell for heat shock protein (HSP) and implicated the cross-presentation of HSP-chaperoned antigens. Here, we show that is not required antitumor generated HSP-based (e.g., grp170) vaccine approaches vivo. lack significantly...
Abstract Although Act1 (adaptor for IL-17 receptors) is necessary IL-17-mediated inflammatory responses, - (but not Il17ra- , Il17rc- or Il17rb -) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that functions as a negative regulator in T B cells via direct inhibition of STAT3. Mass spectrometry analysis detected an Act1–STAT3 complex, deficiency Il17ra -, ) results hyper IL-23- IL-21-induced STAT3 activation cells, respectively. IL-23R deletion blockade...
Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have caused multiple waves of infection globally. This phase 2/3 study evaluated the safety and immunogenicity bivalent vaccine candidate mRNA-1273.211 (equal mRNA amounts ancestral SARS-CoV-2 Beta variant spike proteins) as 50-µg (n=300) 100-µg (n=595) first booster doses approximately 8.8-9.8 months after mRNA-1273 primary series. The (50 100-µg) elicited higher neutralizing antibody responses against than that...