A5065523729- Ruminant Nutrition and Digestive Physiology
- Reproductive Physiology in Livestock
- Animal health and immunology
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Genetic and phenotypic traits in livestock
- Effects of Environmental Stressors on Livestock
- Turfgrass Adaptation and Management
- Food composition and properties
- Milk Quality and Mastitis in Dairy Cows
- IL-33, ST2, and ILC Pathways
- Animal Behavior and Welfare Studies
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
- Selenium in Biological Systems
- Biofuel production and bioconversion
- Digestive system and related health
- Psoriasis: Treatment and Pathogenesis
- Reproductive System and Pregnancy
- Microbial infections and disease research
- Genetic Mapping and Diversity in Plants and Animals
- Animal Nutrition and Physiology
- Agricultural Productivity and Crop Improvement
China Agricultural University
2016-2025
Sichuan Agricultural University
2022-2025
State Key Laboratory of Animal Nutrition
2017-2023
Cleveland Clinic
2020-2023
Cleveland Clinic Lerner College of Medicine
2018-2022
Henan University of Technology
2022
Henan University of Science and Technology
2021
Chinese People's Liberation Army
2014
China University of Geosciences (Beijing)
2002
Abstract Background Antimicrobials are often used to prevent and treat diarrhea induced by enteroaggregative Escherichia coli (EAEC) in young ruminants. However, drug overuse or misuse accelerates the spread of multidrug-resistant extended-spectrum β-lactamase (ESBL)-producing E. . Thus, supplementary foods as alternatives antibiotics needed colibacillus neonatal dairy calves. Ursodeoxycholic acid (UDCA), a therapeutic bile acid, helps alleviate colitis. how UDCA ESBL-EAEC-induced clinical...
NLRP3 inflammasome plays a critical spatiotemporal role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). This study reports mechanistic insight into noncanonical activation microglia for effector stage EAE. Microglia-specific deficiency ASC (apoptosis-associated speck-like protein containing C-terminal caspase-activation and recruitment [CARD] domain) attenuated T cell expansion neutrophil during EAE pathogenesis. Mechanistically, TLR stimulation led to...
Postbiotics, which comprise inanimate microorganisms or their constituents, have recently gained significant attention for potential health benefits. Extensive research on postbiotics has uncovered many beneficial effects hosts, including antioxidant activity, immunomodulatory effects, gut microbiota modulation, and enhancement of epithelial barrier function. Although these features resemble those probiotics, the stability safety make them an appealing alternative. In this review, we provide...
The aim of the study was to evaluate effects Saccharomyces cerevisiae fermentation products (SCFP) on performance and health calves during first 63 d age. Sixty Holstein (30 males 30 females) at 2 age were blocked by sex date birth then randomly assigned within blocks 1 3 treatments. A texturized calf starter fed ad libitum containing 0 (control), 0.5, or 1% SCFP (Original XPC, Diamond V, Cedar Rapids, IA) DM. In addition, supplemented g/d (SmartCare, V) in milk until 30. All 4 L colostrum h...
Live body weight (LBW) is one of the most important parameters for supervising growth and development livestock. The yak (Bos grunniens) a special species cattle that lives on Qinghai-Tibetan Plateau. Yaks are more untamed than regular breeds, so it challenging to measure their LBW. In this study, YOLOv8 detection LBW estimation models were used automatically estimate in real time. First, proper posture (normal posture) individual identification was confirmed then model from 2-dimensional...
IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is hallmark severe asthma and chronic obstructive pulmonary disease (COPD). Through RNA sequencing analysis transcriptomes human smooth muscle cells treated with IL-17A, dexamethasone (DEX, synthetic glucocorticoid drug), alone or combination, we identified group genes that are synergistically induced by DEX, including neutrophil-promoting cytokine CSF3. In type-17 (Th17/IL-17Ahi)...
The dominant bacteria in the hindgut of calves play an important role their growth and health, which could even lead to lifelong consequences. However, identification core probiotics its mechanism regulating host remain unclear. Here, a total 1045 fecal samples were analyzed by 16S rRNA gene sequencing from 408 Holstein dairy at age 0, 14, 28, 42, 56, 70 days characterize dynamic changes taxa. Moreover, mechanisms nutrient metabolism calf regulated investigated using multi-omics analyses....
The growth and health of young ruminants are regulated by their gut microbiome, which can have lifelong consequences. Compared with subjective grouping, phenotypic clustering might be a more comprehensive approach to revealing the relationship between calf state core microbes. However, identification beneficial bacteria its internal mechanisms shaping host phenotype differentiation remains unclear. In this study, calves were divided into two clusters, cluster1 cluster2, based on 29...
Ruminants fed high concentrate diets (HCD) are highly susceptible to foamy rumen bloat, but up now the cause of foam formation is unknown, making it difficult prevent effectively. Exp. 1 this study investigated relationship between saccharide content in fluid (RF) and foaming performance, explored effect supplementing non-starch polysaccharides (NSP) enzymes RF on performance. The 16 HCD-fed goats was used as experimental material correlate viscosity, content. Subsequently, from 4 with...
This experiment aimed to evaluate the impact of various feed additive-treated silage corn straw on growth performance, blood parameters, nutrient apparent digestibility, and rumen fermentation in Simmental cattle. Eighteen healthy bulls (275.64 ± 15.27 kg) were randomly assigned three groups, each consisting six bulls: a control group (CON) receiving basal diet, an experimental group, (OS) wherein 20% rice group’s diet was substituted with treated organic acid, another (MS) replaced mixed...
As one of the important components placental structure, integrity trophoblast cells is crucial for function. When oxidative stress continues to act on cells, it can cause changes in structure and Research has shown that folic acid (FA) a certain alleviating effect functional damage caused by stress, but mechanism action still unclear. Therefore, this study focuses bovine (BPTCs) explore effects mechanisms which FA regulates with aim providing theoretical foundation improving reproductive...
Abstract The community structure of colonised bacteria in the gastrointestinal tracts (GITs) pre-weaned calves is affected by extrinsic factors, such as genetics and diet calves; however, dietary impact not fully understood warrants further research. Our study revealed that a total 6, 5, 2 10 bacterial genera showed biologically significant differences GITs fed four waste-milk diets: acidified waste milk, pasteurised untreated bulk respectively. Specifically, generic biomarkers were observed...
Abstract Although Act1 (adaptor for IL-17 receptors) is necessary IL-17-mediated inflammatory responses, - (but not Il17ra- , Il17rc- or Il17rb -) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that functions as a negative regulator in T B cells via direct inhibition of STAT3. Mass spectrometry analysis detected an Act1–STAT3 complex, deficiency Il17ra -, ) results hyper IL-23- IL-21-induced STAT3 activation cells, respectively. IL-23R deletion blockade...