A5089139627- Asthma and respiratory diseases
- Regulation of Appetite and Obesity
- Tea Polyphenols and Effects
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- Biochemical Analysis and Sensing Techniques
- Barrier Structure and Function Studies
- Ion channel regulation and function
- Pediatric health and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Hydrogen's biological and therapeutic effects
- Morinda citrifolia extract uses
- Immune cells in cancer
- Exercise and Physiological Responses
- Biochemical effects in animals
- Drug Transport and Resistance Mechanisms
- Inflammasome and immune disorders
Dongguan People’s Hospital
2024-2025
Guangdong Medical College
2021-2025
Cleveland Clinic
2017-2020
Louisiana State University
2016
Pennington Biomedical Research Center
2013-2014
Sun Yat-sen University
2009
The blood–brain barrier (BBB) is a regulatory interface between the central nervous system and rest of body. However, BBB changes in obesity metabolic syndrome have not been fully elucidated. We hypothesized that reduces energy metabolism cerebral microvessels composing BBB, reflected by downregulation protein expression function. performed comparative proteomic analyses enriched from cortex mice 2 months after ingestion high-fat diet or regular rodent chow. In with diet-induced (DIO), there...
A molecule from red berries blocks the activity of a proinflammatory cytokine and alleviates inflammation in mice.
IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is hallmark severe asthma and chronic obstructive pulmonary disease (COPD). Through RNA sequencing analysis transcriptomes human smooth muscle cells treated with IL-17A, dexamethasone (DEX, synthetic glucocorticoid drug), alone or combination, we identified group genes that are synergistically induced by DEX, including neutrophil-promoting cytokine CSF3. In type-17 (Th17/IL-17Ahi)...
Abstract Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases, but the signaling mechanism that triggers this function is not fully understood. We showed p38α activity DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals Th2-instructive cytokines. p38α-specific deletion cDC1s cDC2s or macrophages promoted Th2 responses under stimulation. Further study Th2-cell differentiation modulating MK2−c-FOS−IL-12 axis....
Abstract Recent evidence has increasingly underscored the importance of neuro-immune axis in mediating allergic airway diseases, such as asthma and rhinitis. The intimate spatial relationship between neurons immune cells suggests that their interactions play a pivotal role regulating inflammation. Upon direct activation by allergens, engage interactions, during which neurotransmitters neuropeptides released modulate cell activity. Meanwhile, release inflammatory mediators histamine...
Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it very important to develop effective therapeutics and medicines deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory antibacterial effects, while its low water solubility bioavailability greatly limit curative efficiency. To improve nasal mucosa absorption poorly...
Patients with ALI (acute lung injury)/ARDS respiratory distress syndrome) are often septic and poor prognosis, which leads to a high mortality rate of 25–40%.
The importance of CD4
Acute lung injury (ALI) is an inflammatory response which causes serious damages to alveolar epithelia and vasculature, it still remains high lethality mortality with no effective treatment. Based on the homing of platelets cell membrane cloaking nanotechnology, in this study we developed a biomimetic anti-inflammation nanoparticle delivery system for ALI PM@Cur-RV NPs were designed by combining poly (lactic-co-glycolic acid) nanoparticles (NPs) coated platelet vesicles (PM) purpose highly...
Interleukin (IL)-15 is a ubiquitously expressed cytokine that in the basal state mainly localized intracellularly, including nucleus. Unexpectedly, tumor necrosis factor-α (TNF) time-dependently induced nuclear export of IL-15Rα and IL15. This process was inhibited by leptomycine B (LMB), specific inhibitor receptor chromosomal region maintenance 1 (CRM1). In presence TNF, LMB co-treatment led to accumulation both IL-15 nucleus HeLa cells, suggesting CRM1 facilitates TNF enhances activity....
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type-specific deletion IL-17R adaptor Act1, we demonstrated that IL-17R/Act1 exerts direct impact on contraction smooth muscle cells (ASMCs). Mechanistically, induced recruitment Rab35 (a small monomeric GTPase) DennD1C (guanine nucleotide exchange factor [GEF]) to complex in ASMCs, resulting activation Rab35....
Tea polyphenols (TPs), prominent constituents of green tea, possess remarkable antioxidant and anti-inflammatory properties. However, their therapeutic potential is limited due to low absorption poor bioavailability. To address this limitation enhance efficacy, we developed a biomimetic nanoplatform by coating platelet membrane (PM) onto poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) create targeted delivery vehicles for TPs (PM@TP/NPs) the inflamed tissues in asthma.
Abstract Hyperleptinemia is usually associated with obesity and leptin resistance. Endothelial cell receptor knockout (ELKO) mice without a signaling membrane‐bound in endothelia, however, have profound hyperleptinemia signs of Leptin mRNA adipose tissue was unchanged. To test the hypothesis that ELKO mutation results delayed degradation slowed excretion, we determined kinetics transfer groups wildtype after intravenous bolus injection 125 I‐leptin reference substance 131 I‐albumin. The...
Ovalbumin (OVA) is the major allergenic protein that can induce T helper 2 (Th2)-allergic reactions for which current treatment options are inadequate. In this study, we developed a polymerized hypoallergenic OVA product via laccase/caffeic acid (Lac/CA)-catalyzed crosslinking in conjunction with galactomannan (Man). The formation of high molecular weight crosslinked polymers and IgG-binding were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) western...
Polyethyleneimine (PEI) has been broadly studied as a leading nonviral gene delivery carrier because of its relatively high transfection efficiency in wide range cell types. Here, we report transfer zebrafish cells (ZF4) using PEI and lipofectamine control. Formations PEI–DNA complexes were characterized by series measurements. The particle size decreased from 274 to 132 nm, the surface charge gradually increased −26 29 mV, cytotoxicity for was observed with increasing proportion PEI. Gel...
<title>Abstract</title> Asthma presents as a chronic allergic condition characterized by airway inflammation, increased responsiveness, and mucus accumulation. Reactive oxygen species (ROS) are central to its inflammatory cascade pathology. Hence, we theorized that antioxidants could offer promising therapeutic strategy for house dust mite (HDM)-induced asthma. Our study reveals Tea Polyphenols (TPs) encapsulated in biocompatible nanoparticles, enveloped with platelet membranes (PM@TP/NPs),...
Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse psoriasiform model, p38 activity significantly elevated in KCs p38α specific deletion ameliorates skin inflammation. signaling promotes KC proliferation psoriasis-related proinflammatory gene expression during psoriasis development. Mechanistically, enhances production of cytokines chemokines activating STAT3. While does not...
Type I diabetes (T1D) is an organ-specific autoimmune disease that targets on the destruction of insulin-producing pancreatic β cells. Many strategies, including immunosuppressive and antigen-specific immunoregulatory therapies, have been per- formed in animal models clinic to prevent treat T1D. Among them, induction regulatory T cells (Treg) specific cell-associated autoantigens (BAA) for T1D therapy provides several advantages, specificity lasting effica- cy controlling unrestricted...
Abstract The spontaneously occurred lymphomas in SJL/J mice have many pathological features similar to Hodgkin’s lymphoma human. malignant growth of the tumor cells is dependent on support host FoxP3+ CD4+ regulatory T (Tregs). In this study, we report that golli protein, a negative regulator CRAC (calcium release activated calcium) channel cells, plays critical role tumorigenesis Hodgkin’s-like lymphoma. ablation protein results an accelerated progression which associated with facilitated...