A5078464849- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Nuclear Structure and Function
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Drug-Induced Hepatotoxicity and Protection
Cleveland Clinic Lerner College of Medicine
2017-2025
Cleveland Clinic
2018-2022
Case Western Reserve University
2022
Increasing evidence suggests that intratumoral inflammation has an outsized influence on antitumor immunity. Here, we report IL-17, a proinflammatory cytokine widely associated with poor prognosis in solid tumors, drives the therapeutic failure of anti-PD-L1. By timing deletion IL-17 signaling specifically cancer-associated fibroblasts (CAFs) late-stage show immune exclusion by activating collagen deposition program murine models cutaneous squamous cell carcinoma (cSCC). Ablation CAFs...
IL-17A plays an important role in the pathogenesis of asthma, particularly neutrophilic corticosteroid (CS)-resistant subtype asthma. Clinical studies suggest that a subset asthma patients, i.e., Th17/IL-17A-mediated (type 17) CS-resistant may improve with Th17/IL-17A pathway blockade. However, little is known about mechanisms underlying type 17 and CS response. In this article, we show blood levels lipocalin-2 (LCN2) serum amyloid A (SAA) are positively correlated not inhibited by high-dose...
Expression of inflammatory genes is determined in part by post-transcriptional regulation mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence poorly understood. Here, we report a novel pathway which LPS/TLR4 engagement promotes localization IRAK2 to facilitate specific subset inflammation-related mRNAs for translation murine macrophages. kinase activity required LPS-induced RanBP2-mediated sumoylation subsequent translocation. Array analysis showed that an...
The IL-17 receptor adaptor molecule Act1, an RNA-binding protein, plays a critical role in IL-17–mediated cancer progression. Here, we report novel mechanism of how IL-17/Act1 induces chemoresistance by modulating redox homeostasis through epitranscriptomic regulation antioxidant RNA metabolism. Transcriptome-wide mapping direct Act1–RNA interactions revealed that Act1 binds to the 5′UTR mRNAs and Wilms’ tumor 1–associating protein (WTAP), key regulator m6A methyltransferase complex....