A5101861148- Viral-associated cancers and disorders
- interferon and immune responses
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- Viral Infections and Vectors
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Cardiac, Anesthesia and Surgical Outcomes
- Eosinophilic Disorders and Syndromes
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Systemic Sclerosis and Related Diseases
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- T-cell and Retrovirus Studies
- Multiple Sclerosis Research Studies
- Antifungal resistance and susceptibility
- RNA and protein synthesis mechanisms
University of Nebraska–Lincoln
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Guangdong Medical College
2024
Yanbian University
2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2023
Sichuan Agricultural University
2021-2023
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Fudan University
2022
Southern Medical University
2022
Dengue virus type 2, a member of the family Flaviviridae, encodes single polyprotein precursor consisting 3391 amino acid residues that is processed to at least 10 mature proteins by host and viral proteases. The NS3 protein contains domain commonly found in cellular serine proteinases cooperation with NS2B involved processing. In addition, NS5 contain conserved motifs several RNA helicases RNA-dependent polymerases, respectively. Both enzymatic activities have been suggested be replication....
The emergence of jaws in early vertebrates introduced a novel feeding apparatus and powerful oral defenses, but it also increased the risk physical injury pathogen exposure. Interferon regulatory factors (IRFs) play critical roles orchestrating innate immunity inflammation response to invading microbes tissue damage, with their subcellular localization being essential some IRFs' function. Our results indicate that IRF members underwent independent expansion diversification two distinct...
ABSTRACT Epstein-Barr virus (EBV) infection is associated with many human malignancies. In vitro, EBV transforms primary B lymphocytes into continuously growing lymphoblastoid cell lines. latent membrane protein 1 (LMP-1) required for transformation processes. Interferon regulatory factor 4 (IRF-4) a transcription and has oncogenic potential. We find that high levels of IRF-4 are cells in vitro type III latency which LMP-1 expressed. show stimulates expression lymphocytes. The stimulation by...
Kaposi sarcoma-associated herpesvirus (KSHV) is a human γ-herpesvirus associated with several malignancies. The replication and transcription activator (RTA) necessary sufficient for the switch from KSHV latency to lytic replication. Toll-interleukin-1 receptor (TIR) domain-containing adaptor-inducing β-interferon (TRIF, also called TIR-domain-containing adaptor molecule-1 (TICAM-1)) signaling molecule that critically involved in Toll-like 3 (TLR-3) TLR-4 pathways type I interferon (IFN)...
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that participates in HIV-1 pathogenesis through depletion CD4+ T cells. TRAIL expressed on cell membrane peripheral immune cells and can be cleaved into soluble, secreted form. The regulation macrophages during infection not completely understood. In this study, we investigated mechanism(s) expression HIV-1-infected macrophages, an important type pathogenesis. A human monocyte-derived macrophage (MDM) culture system...
Background This study aimed to investigate the Aspergillus species distribution, antifungal sensitivities, clinical characteristics, and risk factors of patients with invasive aspergillosis (IA) in a tertiary teaching hospital Anhui Province. Methods In present study, 156 isolates were collected from admitted 2,800-bed comprehensive between January 2019 April 2021. The epidemiology was well-examined, its susceptibility specifically measured by microbroth dilution method. IA documented...
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus. It causes mortality in neonatal piglets and of growing concern because its broad host range, including humans. To date, the mechanism PDCoV infection remains poorly understood. Here, based on a genome-wide CRISPR screen PDCoV-infected cells, we found that HSP90AB1 (heat shock protein 90 alpha family class B1) promotes infection. Knockdown or KO LLC-PK cells resulted significantly suppressed Infected treated with...
The cellular interferon regulatory factor-4 (IRF-4), which is a member of IRF family, involved in the development multiple myeloma and Epstein-Barr virus (EBV)-mediated transformation B lymphocytes. However, molecular mechanism IRF-4 unknown. We have found that knockdown leads to high expression IRF-5, pro-apoptotic family. Overexpression represses IRF-5 expression. Reduction growth inhibition, restoration by exogenous plasmids correlates with recovery reduces In addition, negatively...
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus. Toll-like receptor 7 (TLR7) involved in host innate immunity against pathogens, and its aberrant activation linked to the development of systemic lupus erythematosus (SLE, also called “lupus”). Type I interferons (IFN) are apparently driving forces for pathogenesis. Previously, we found that EBV latent membrane protein 1 (LMP1) primes cells IFN production. In this report, relationship among LMP1, TLRs, production examined. We find...
Epstein-Barr virus (EBV) latency has been associated with a variety of human cancers. Latent membrane protein 1 (LMP-1) is one the key viral proteins required for transformation primary B cells in vitro and establishment EBV latency. We have previously shown that LMP-1 induces expression several interferon (IFN)-stimulated genes antiviral effect (Zhang, J., Das, S. C., Kotalik, Pattnaik, A. K., Zhang, L. (2004) J. Biol. Chem. 279, 46335–46342). In this report, novel mechanism related to...
ABSTRACT Human herpesvirus 8 (HHV-8)/Kaposi's sarcoma-associated infection goes through lytic and latent phases that are regulated by viral gene products, but very little is known about the involvement of host proteins. The replication transcription activator (RTA) a protein sufficient to initiate activating downstream genes, including early open reading frame 57 (ORF 57), which codes for posttranscriptional activator. In this study, we demonstrate cellular interferon regulatory factor 7...
Ergothioneine (ERG) is an unusual sulfur-containing amino acid with antioxidant activity that can be synthesized by certain bacteria and fungi. Microbial fermentation a promising method for ERG production. In this study, the bifunctional enzyme methyltransferase-sulfoxide synthase NcEgt1 from Neurospora crassa was truncated to obtain sulfoxide TNcEgt1, which showed higher expression level in Escherichia coli BL21(DE3). Then, genes egtD encoding methyltransferase EgtD egtE C-S lyase EgtE...
ABSTRACT Kaposi's sarcoma-associated herpesvirus (also called human 8 [HHV-8]) replication and transcription activator (RTA) is apparently necessary sufficient for the switch from viral latency to lytic replication. RTA may regulate open reading frame (ORF) K14 (viral OX-2 homologue) ORF74 G-protein-coupled receptor genes through an interferon-stimulated response element (ISRE)-like sequence (K14 ISRE) in promoter region. strongly activated a ISRE-containing K14-ORF74 reporter construct...
BackgroundBoth Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are members of the human gamma family: each is associated with various cancers. The majority AIDS-associated primary effusion lymphoma (PEL) co-infected both KSHV EBV. Dually-infected PELs selectively switch from latency to lytic replication either or EBV in response chemical stimuli. transcription activator (K-RTA) necessary sufficient for replication, while BZLF1 gene product (EBV-Z) a critical...
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a human gammaherpesvirus associated with several malignancies. The replication and transcription activator (RTA) necessary sufficient for the switch from KSHV latency to lytic replication. Interleukin 1 (IL-1) major mediator inflammation plays an important role in both innate adaptive immunity. Myeloid differentiation primary response gene 88 (MyD88) essential adaptor molecule IL-1 as well most Toll-like receptor signaling. In this...