A5100624092- Microbial infections and disease research
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- Plant Virus Research Studies
- Animal Disease Management and Epidemiology
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Fungal Infections and Studies
- Polyamine Metabolism and Applications
- Nail Diseases and Treatments
- Toxoplasma gondii Research Studies
- vaccines and immunoinformatics approaches
- RNA regulation and disease
- Rabies epidemiology and control
Sichuan Agricultural University
2016-2025
Ministry of Education of the People's Republic of China
2024-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Science and Technology Department of Sichuan Province
2025
Central University of Finance and Economics
2022-2024
Dongbei University of Finance and Economics
2023
Peking Union Medical College Hospital
2021-2022
City Of Hope National Medical Center
2022
Huazhong University of Science and Technology
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis vivo.
Non-obstructive azoospermia (NOA) is a complex and severe condition whose etiology remains largely unknown. In genome-wide association study (GWAS) of NOA in Chinese men, few loci reached significance, although this might be result genetic heterogeneity. Single nucleotide polymorphisms (SNPs) without significance may also indicate genes that are essential for fertility, multiple stage validation can lead to false-negative results. To perform large-scale functional screening the surrounding...
Porcine deltacoronavirus (PDCoV) is a newly emerging enteric pathogen in swine that causes diarrhea neonatal piglets and creates an additional economic burden on porcine industries Asia North America. In this study, PDCoV isolate, CHN-SC2015, was isolated from Sichuan Province southwest China. The isolate characterized by cytopathic effect, immunofluorescence, electron microscopy. CHN-SC2015 titers LLC-PK cells ranged 104.31 to 108.22 TCID50/mL during the first 30 passages. During serial...
Intestinal microbiota composition plays a crucial role in modulating the health of host. This evaluation indicator is very sensitive and profoundly impacts protection endangered species. Currently, information on gut wild birds remains scarce. Therefore, this study aimed to describe microbial community structure potentially, pathogen Arborophila rufipectus.To guarantee comprehensive data analysis, we collected fecal samples from A. rufipectus Lophura nycthemera their habitats for two...
After being discovered for the first time in China 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become prevalent strain of PRRSV certain regions China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like CF had a better protection effect than normal dosage. However, protective is unclear. Therefore, this compared effectiveness 0.1 1 infection using commercial vaccines, MLV, which been widely utilized...
Background The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is known for its capacity to cause severe neurological disease in Asia. Neurotropic flaviviruses within the (JE) serogroup possess distinctive feature of expressing unique nonstructural protein, NS1′. NS1′ protein consists full NS1 with an additional 52 amino acid extension at C-terminus and has been demonstrated exhibit virulence mammalian hosts upon infection. However, precise role mosquito vectors yet be...
Haemophilus parasuis is an opportunistic pathogen that causes Glässer's disease in swine, with polyserositis, meningitis, and arthritis. The high-temperature requirement A (HtrA)-like protease, which involved protein quality control, has been reported to be a virulence factor many pathogens. In this study, we showed HtrA of H. (HpHtrA) exhibited both chaperone protease activities. Finally, nickel import ATP-binding (NikE), periplasmic dipeptide transport (DppA), outer membrane (OmpA) were...
Haemophilus parasuis is known as a commensal organism discovered in the upper respiratory tract of swine where pathogenic bacteria survive various adverse environmental stress. QseC, histidine protein kinase two-component regulatory systems CheY/QseC, involved adaptation bacteria. To investigate role QseC coping with environment stresses and host, we constructed qseC mutant H. serovar 13 strain (ΔqseC), MY1902. In this study, found that was stress tolerance parasuis, by ΔqseC exhibited...
In patients with treatment-naive diffuse large B-cell lymphoma (DLBCL), the POLARIX study (A Study Comparing Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, Prednisone [R-CHP] Versus Vincristine, [R-CHOP] in Participants Diffuse Large B-Cell Lymphoma) reported a 6.5% improvement 2-year progression-free survival (PFS), no difference overall (OS) or safety using polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, prednisone (pola-R-CHP)...
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus. It causes mortality in neonatal piglets and of growing concern because its broad host range, including humans. To date, the mechanism PDCoV infection remains poorly understood. Here, based on a genome-wide CRISPR screen PDCoV-infected cells, we found that HSP90AB1 (heat shock protein 90 alpha family class B1) promotes infection. Knockdown or KO LLC-PK cells resulted significantly suppressed Infected treated with...
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Pasteurella multocida, a zoonotic pathogen that produces 146-kDa modular toxin (PMT), causes progressive atrophic rhinitis with severe turbinate bone degradation in pigs. However, its mechanism of cytotoxicity remains unclear. In this study, we expressed PMT, purified it prokaryotic expression system, and found killed PK15 cells. The host factor CXCL8 was significantly upregulated among the differentially genes transcriptome sequencing analysis qPCR verification. We constructed...
Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a significant disease that causes serious economic losses to swine industry worldwide. Persistent infections caused by bacterial biofilms are recalcitrant treat because particular drug resistance biofilm-dwelling cells. TolC, key component multidrug efflux pumps, responsible for (MDR) in many Gram-negative bacteria. In this study, we identified two TolC-like proteins, TolC1 and TolC2, A....
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a severe threat to the health of pigs globally. Host factors play critical role in PRRSV replication. Using as model for genome-scale CRISPR knockout (KO) screening, we identified host factor infection: sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B). Our findings show that SMPDL3B restricted attachment, entry, replication, secretion its depletion significantly inhibited proliferation, indicating plays positive data...
Haemophilus parasuis, belonging to the family Pasteurellaceae, is causative agent of Glässer's disease leading serious economic losses. In this study, a successive markerless mutation system for H. parasuis using two sequential steps natural transformation was developed. By first homologous recombination, target genes were replaced by cassette carrying kanamycin resistance gene and sacB (which confers sensitivity sucrose) selection, followed second reconstruction remove selection cassette,...
The Japanese encephalitis virus (JEV), a causative agent of severe viral in humans, has biological cycle fluctuating between transmission mosquitoes and avian species amplification pigs. Contact JEV was recently shown pigs the absence arthropod vectors. Here, we show infected contact mice further demonstrate that occurs animals via aerosols, as both RNA infectious were detected direct contact- aerosol-exposed animals. results this study change our understanding densely populated regions may...
Porcine deltacoronavirus (PDCoV), first identified in 2012, is a swine enteropathogen now found many countries. The nucleocapsid (N) protein, core component of PDCoV, essential for virus replication and significant candidate the development diagnostics PDCoV. In this study, monoclonal antibodies (mAbs) were generated tested reactivity with three truncations full protein (N1, N2, N3) that contained partial overlaps; five monoclonals chosen tested, each reacted only N3 truncation. antibody...