A5102489733- Microbial infections and disease research
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Poxvirus research and outbreaks
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Plant and Fungal Interactions Research
- vaccines and immunoinformatics approaches
- Viral Infectious Diseases and Gene Expression in Insects
- Dietary Effects on Health
- Rice Cultivation and Yield Improvement
- Fungal Biology and Applications
- Viral Infections and Vectors
- Rabies epidemiology and control
- Nail Diseases and Treatments
- Viral-associated cancers and disorders
Southwest Medical University
2020-2024
Model Animal Research Center
2022-2024
Sichuan Agricultural University
2015-2019
Haemophilus parasuis is known as a commensal organism discovered in the upper respiratory tract of swine where pathogenic bacteria survive various adverse environmental stress. QseC, histidine protein kinase two-component regulatory systems CheY/QseC, involved adaptation bacteria. To investigate role QseC coping with environment stresses and host, we constructed qseC mutant H. serovar 13 strain (ΔqseC), MY1902. In this study, found that was stress tolerance parasuis, by ΔqseC exhibited...
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as most threatening orthopoxvirus world. In this study, we conducted a comprehensive analysis of currently published complete genome sequences virus. The core/variable regions were identified through core-pan MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy repeat sequences, and recombination fragments are primarily distributed variable region. This result...
The members of the Poxviridae family are globally distributed all over world and can cause infectious diseases. Although genome sequences publicly available for representative isolates genera, studies on criteria genome-based classification within have rarely been reported. In our study, 60 genomes were re-annotated using Prokka. By BLAST filtration MCScanX, synteny similarity whole genomic amino acid visualized. According to analysis pattern, Chordopoxvirinae Entomopoxvirinae subfamilies be...
Average nucleotide identity (ANI) is a prominent approach for rapidly classifying archaea and bacteria by recruiting both whole genomic sequences draft assemblies. To evaluate the feasibility of ANI in virus taxon demarcation, 685 poxviruses were assessed. Prior to analysis, fragment length threshold value optimized as 200 bp 98 per cent, respectively. After analysis network visualization, resulting sixty-one species (ANI rank) clustered largely consistent with groupings found National...
Members of the family Iridoviridae (iridovirids) are globally distributed and trigger adverse economic ecological impacts on aquaculture wildlife. Iridovirids taxonomy has previously been studied based a limited number genomes, but this is not suitable for current future virological studies as more iridovirids emerging. In our study, 57 representative genomes were selected from total 179 whole available NCBI. Then 18 core genes screened out members Iridoviridae. Average amino acid sequence...
Haemophilus parasuis causes Glässer's disease and pneumonia, incurring serious economic losses in the porcine industry. In this study, natural competence was investigated H. parasuis. We found genes homologous to ones influenzae a high consensus battery of Sxy-dependent cyclic AMP (cAMP) receptor protein (CRP-S) regulons using bioinformatics. High rates were from onset stationary-phase growth condition mid-stationary phase (OD600 0.29 1.735); rapidly dropped off as cells reached 1.735...
The widespread two-component system (TCS), QseBC, involves vital virulence regulators in Enterobacteriaceae and Pasteurellaceae . Here we studied the function of QseBC Glaesserella parasuis A Δ qseBC mutant was constructed using a serovar 11 clinical strain SC1401 by natural transformation. Immunofluorescence used to evaluate cellular adhesion, levels inflammation apoptosis. ability qseC strains adhere PAM MLE-12 cells significantly reduced. Additionally, focusing on signs, H&E, IFA for...
The family Alloherpesviridae contains herpesviruses of fish and amphibians. Due to the significant economic losses aquaculture that can cause, primary areas research interest are concerning their pathogenesis prevention. Despite alloherpesvirus genomic sequences becoming more widely accessible, methods regarding genus/species classification still relatively unexplored. In present study, phylogenetic relationships between 40 completely sequenced alloherpesviruses were illustrated by viral...
Haemophilus parasuis, a normal Gram-negative bacterium, may cause Glässer's disease and pneumonia in pigs. This study aims to identify the genes related natural competence of serotype 11 strain SC1401, which frequently shows high pathogenicity. SC1401 many differences from strains without within molecular basis. We performed complete genome sequencing together with restriction modification system analysis lay foundation for later study.
Ranaviruses can infect both captive and wild cold-blooded vertebrates, leading to significant economic environmental losses. With the cases of ranavirus infection increasing, many genomic sequences were published, but little is known about taxonomy on a whole-genome level. In this study, 44 ranaviruses core genes identified in 32 genome by using PanX. The neighbour-joining phylogenetic trees (NJ-tree) based 24 iridoviridae composition vector tree (CV-Tree) whole constructed. three showed...
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Abstract: NASH cirrhosis is a late-stage nonalcoholic fatty liver disease (NAFLD) characterized by high morbidity, relapse rate, and mortality, which clinical to treat. Presently, transplantation the most effective radical treatment, but it difficult be widely carried out due problems of large surgical trauma, lack donors, strong immunological rejection. Bone marrow mesenchymal stem cells (BMSCs) are type cell with characteristics self-replication, multidirectional differentiation, easy...