A5016724043- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Nail Diseases and Treatments
- Streptococcal Infections and Treatments
- Plant Virus Research Studies
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Plant and Fungal Interactions Research
- Respiratory viral infections research
- Circular RNAs in diseases
- Poxvirus research and outbreaks
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Fungal Biology and Applications
- Cytomegalovirus and herpesvirus research
- Polysaccharides and Plant Cell Walls
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Animal Disease Management and Epidemiology
- Dietary Effects on Health
Southwest Medical University
2020-2024
Model Animal Research Center
2022-2023
Sichuan Agricultural University
2017-2020
Bovine milk is rich in exosomes, which contain abundant miRNAs and play important roles the regulation of neonatal growth development adaptive immunity. Here, we analyzed miRNA expression profiles bovine exosomes from three healthy mastitic cows, then six libraries were constructed. Interestingly, detected no scRNAs few snRNAs exosomes; this result indicated a potential preference for RNA packaging exosomes. A total 492 known 980 novel exosomal detected, 10 most expressed samples accounted...
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as most threatening orthopoxvirus world. In this study, we conducted a comprehensive analysis of currently published complete genome sequences virus. The core/variable regions were identified through core-pan MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy repeat sequences, and recombination fragments are primarily distributed variable region. This result...
Heat stress affects milk yield and quality in lactating dairy cows summer. Bovine mammary epithelial cells (bMECs) play a key role secretion, microRNAs (miRNAs) regulate numerous functions of bMEC. Previous reports have verified that miR-216b regulated cell apoptosis through repressing target genes several cancer cells. So, our purpose was to explore the potential involvement heat stress-induced bMECs. Firstly, model constructed we found apoptotic rates bMECs significantly increased under...
The members of the Poxviridae family are globally distributed all over world and can cause infectious diseases. Although genome sequences publicly available for representative isolates genera, studies on criteria genome-based classification within have rarely been reported. In our study, 60 genomes were re-annotated using Prokka. By BLAST filtration MCScanX, synteny similarity whole genomic amino acid visualized. According to analysis pattern, Chordopoxvirinae Entomopoxvirinae subfamilies be...
Average nucleotide identity (ANI) is a prominent approach for rapidly classifying archaea and bacteria by recruiting both whole genomic sequences draft assemblies. To evaluate the feasibility of ANI in virus taxon demarcation, 685 poxviruses were assessed. Prior to analysis, fragment length threshold value optimized as 200 bp 98 per cent, respectively. After analysis network visualization, resulting sixty-one species (ANI rank) clustered largely consistent with groupings found National...
Members of the family Iridoviridae (iridovirids) are globally distributed and trigger adverse economic ecological impacts on aquaculture wildlife. Iridovirids taxonomy has previously been studied based a limited number genomes, but this is not suitable for current future virological studies as more iridovirids emerging. In our study, 57 representative genomes were selected from total 179 whole available NCBI. Then 18 core genes screened out members Iridoviridae. Average amino acid sequence...
Abstract Background Dermatophytosis is an intractable superficial mycosis in humans and animals mainly caused by Trichophyton mentagrophytes ( T. ), with a global prevalence of about 20%. Keratinocytes are the most abundant participants skin immunity, they also play role first‐line defence against . However, no studies keratinocyte responses infection based on whole transcriptome have been reported. Objectives Here, we systematically analysed changes keratinocytes infected using sequencing...
The widespread two-component system (TCS), QseBC, involves vital virulence regulators in Enterobacteriaceae and Pasteurellaceae . Here we studied the function of QseBC Glaesserella parasuis A Δ qseBC mutant was constructed using a serovar 11 clinical strain SC1401 by natural transformation. Immunofluorescence used to evaluate cellular adhesion, levels inflammation apoptosis. ability qseC strains adhere PAM MLE-12 cells significantly reduced. Additionally, focusing on signs, H&E, IFA for...
The family Alloherpesviridae contains herpesviruses of fish and amphibians. Due to the significant economic losses aquaculture that can cause, primary areas research interest are concerning their pathogenesis prevention. Despite alloherpesvirus genomic sequences becoming more widely accessible, methods regarding genus/species classification still relatively unexplored. In present study, phylogenetic relationships between 40 completely sequenced alloherpesviruses were illustrated by viral...
Ranaviruses can infect both captive and wild cold-blooded vertebrates, leading to significant economic environmental losses. With the cases of ranavirus infection increasing, many genomic sequences were published, but little is known about taxonomy on a whole-genome level. In this study, 44 ranaviruses core genes identified in 32 genome by using PanX. The neighbour-joining phylogenetic trees (NJ-tree) based 24 iridoviridae composition vector tree (CV-Tree) whole constructed. three showed...
The members of the family Iridoviridae are large, double-stranded DNA viruses that infect various hosts, including both vertebrates and invertebrates. Although great progress has been made in genomic phylogenetic analyses, adequacy existing criteria for classification within remains unknown. In this study, we redetermined 23 core genes by re-annotation, core-pan analysis local BLASTN search. tree based on re-annotated (Maximum Likelihood, ML-Tree) amino acid sequences (composition vector,...