A5100759856- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- RNA and protein synthesis mechanisms
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Whipple's Disease and Interleukins
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Respiratory Support and Mechanisms
- RNA regulation and disease
- Immune Response and Inflammation
- Infective Endocarditis Diagnosis and Management
- Animal Virus Infections Studies
- Aquaculture disease management and microbiota
- Cerebrovascular and Carotid Artery Diseases
- Kawasaki Disease and Coronary Complications
- T-cell and Retrovirus Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Function and Risk Factors
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cardiovascular Issues in Pregnancy
- Fungal Biology and Applications
- Dietary Effects on Health
First Affiliated Hospital of Chengdu Medical College
2025
National Institute for Viral Disease Control and Prevention
2016-2024
Nanfang Hospital
2024
Southwest Medical University
2022-2024
Air Force Medical University
2024
Southern Medical University
2024
Sichuan University of Science and Engineering
2024
Model Animal Research Center
2023
University of Shanghai for Science and Technology
2016-2023
Center for Disease Control
2023
A total of 807 entire VP1 sequences Coxsackievirus A6 (CV-A6) from mainland China 1992 to 2015, including 520 in this study and 287 the GenBank database, were analysed provide a basic framework molecular epidemiological characteristics CV-A6 China. Sixty-five 46 representative isolates Chinese strains 19 international used for describing genotypes sub-genotypes. The results revealed that can be categorised into 4 designated as A, B, C, D according previous data further subdivided B1-B2,...
Abstract Background Ferroptosis is unique among different types of regulated cell death and closely related to organ injury. Whether ferroptosis occurs in sepsis-associated acute kidney injury (SA-AKI) not clear. Nuclear factor-erythroid-2-related factor 2 (Nrf2) crucial the regulation ferroptosis. We others have shown that Maresin conjugates tissue regeneration 1 (MCTR1) or other members specialized pro-resolving mediators (SPMs) can actively regulate inflammation resolution protect organs...
Hand, foot and mouth disease (HFMD) was reported in May 2, 2008 to be the 38th legally notifiable China's National Notifiable Disease Reporting Surveillance System. In order solve infection, an extensive three-level HFMD surveillance laboratory network established. this study, framework of that is assessed incidence China from 2017 using a descriptive epidemiologic method. During these 10 years, series techniques have been widely applied all laboratories. Using information material obtained...
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases. However, effect of IH on cardiac fibrosis and molecular events involved this process are unclear. Here, we tested angiotensin II (Ang II)-induced signaling linked fibroblast activation. triggered aggravated Ang II-induced dysfunction mice. Plasma thrombospondin-1 (TSP1) content was upregulated both IH-exposed mice OSA...
<abstract abstract-type="Abstract"> <sec> <b>Introduction</b> Coxsackievirus A6 (CVA6) has emerged as a significant pathogen responsible for severe cases of hand, foot, and mouth disease (HFMD). This study aims to delineate the demographic characteristics analyze viral evolution HFMD associated with CVA6, thereby assisting in its surveillance management. </sec><sec> <b>Methods</b> In this investigation, 74 strains CVA6 were isolated from samples collected between 2012 2023. The <i>VP1</i>...
Introduction The systemic immune-inflammation index (SII) has been proven to predict the outcome in cancerous and non-cancerous diseases. We aimed investigate relationship between SII other inflammatory markers prognosis patients receiving intravenous thrombolysis (IVT). Methods Acute ischemic stroke treated with IVT were collected retrospectively. SII, neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) constructed based on admission blood testing. Favorable was defined as...
In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common in world. As an important model animal, characteristics of gut microbiota alteration mice with NAFLD have been studied but changes metabolite abundance and how affects these intestinal metabolites remain unclear. this experiment, a mouse for was established by high-fat diet. The use 16S rDNA technology showed that while there were no significant alpha diversity cecum mice, beta changed significantly....
Abstract A driven second‐order negative‐resistance oscillator circuit has been observed experimentally to exhibit infinitely many distinct chaotic states in addition subharmonic responses of all orders. Each state is found be born out a devil's staircase whose steps are spaced accordance with definite period‐adding law . emerges at some level frequency‐tuning resolution, where each embedded within an outer level, ad infinitum The global bifurcation structure self‐similar the sense that upon...
Coxsackievirus B3 (CV-B3) is usually associated with aseptic meningitis and myocarditis; however, the association between CV-B3 hand, foot, mouth disease (HFMD) has not been clearly demonstrated, phylogenetic dynamics transmission history of have well summarized. Two HFMD outbreaks caused by were described in Hebei Province 2012 Shandong 2016 China. To analyze epidemiological features two outbreaks, a retrospective analysis was conducted. All clinical specimens from collected disposed...
Abstract Hand, foot, and mouth disease (HFMD), which is a frequently reported concerning worldwide, severe burden on societies globally, especially in the countries of East Southeast Asia. Coxsackievirus A16 (CV-A16) one most important causes HFMD threat to human health, children under 5 years age. To investigate epidemiological characteristics, spread dynamics, recombinant forms (RFs), other features CV-A16, we leveraged continuous surveillance data CV-A16-related cases collected over an...
Coxsackievirus A10 (CV-A10) associated with Hand, foot, and mouth disease (HFMD) cases emerged increasingly in recent years. In this study, the samples from nation-wide HFMD surveillance, including 27 out of 31 provinces China were investigated, continuous extensive virological covered 13 years, conducted to provide a comprehensive molecular characterization analysis CV-A10. 855 CV-A10 viruses (33 severe included), isolated children patients during 2009 2016 China. 164 representative...
This study sets out to establish the comparative contribution of PD-L1 expression by pulmonary endothelial cells (ECs) and/or epithelial (EpiCs) development indirect acute lung injury (iALI) taking advantage observation that treatment with naked siRNA intratracheal delivery in mice primarily affects EpiCs, but not ECs, while intravenous liposomal-encapsulated largely targets vascular ECs including lung, EpiCs. We showed using a mouse model iALI [induced hemorrhagic shock followed septic...
Abstract Background Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), pancreatitis, is a heavy burden on public health. However, CVB3 not been systematically analyzed with regard to whole-genome diversity recombination. Therefore, this study was undertaken examine the genetic characteristics of based its whole genome. Methods We combined isolates from our national HFMD surveillance global sequences retrieved...
Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on have been conducted China or worldwide. More information research needed assess its genetic characteristics, phylogenetic relationships, association with enteroviral diseases. In this study, we report characteristics three Xinjiang strains one Tibet strain China. The four show 78.8-79% nucleotide...
Abstract Hand, foot, and mouth disease (HFMD) is a common global epidemic. From 2008 onwards, many HFMD outbreaks caused by coxsackievirus A6 (CV-A6) have been reported worldwide. Since 2013, with dramatically increasing number of CV-A6-related cases, CV-A6 has become the predominant pathogen in mainland China. Phylogenetic analysis based on VP1 capsid gene revealed that subtype D3 dominated outbreaks. Here, we performed large-scale (near) full-length genetic Chinese variants, including 158...
To maintain alveolar gas exchange, the surface has to limit unnecessary inflammatory responses. This involves crosstalk between epithelial cells (AECs) and macrophages (AMs) in response damaging factors. We recently showed that insulin growth factor (IGF)-1 regulates phagocytosis of AECs. AMs secrete IGF-1 into bronchoalveolar lavage fluid (BALF) stimuli. However, whether AECs regulate production by signals remains unclear, as well role controlling balance under conditions. In this study, we...
Coxsackievirus A2 (CV-A2) has been frequently detected and commonly associated with hand, foot, mouth disease (HFMD) in China since 2008. However, limited sequences of CV-A2 are currently available. As a result, we have focusing on the genetic characteristics mainland during 2008-2015 based national HFMD surveillance. In this study, 20 strains were isolated phylogenetic analyses VP1 performed. Full-length genome two representative isolates acquired similarity plot bootscanning The dendrogram...
Inflammatory cell infiltration contributes to the pathogenesis of acute respiratory distress syndrome (ARDS). Protectin DX (PDX), an endogenous lipid mediator, shows anti-inflammatory and proresolution bioactions. In vivo, mice were intraperitoneally injected with PDX (0.1 µg/mouse) after intratracheal (1 mg/kg) or intraperitoneal (10 LPS administration. Flow cytometry was used measure inflammatory numbers. Clodronate liposomes deplete resident macrophages. RT-PCR, ELISA MIP-2, MCP-1, TNF-α...
Abstract Poliomyelitis associated with circulating vaccine-derived polioviruses (cVDPVs) is a serious public health issue in the post-eradication era and occurrence of recombinant cVDPVs emphasizes need to elucidate enterovirus C (EV-C) epidemiology. Stool samples were collected from 826 healthy children Southern Xinjiang 2011 investigate EV-C circulation Thirty-six EV-Cs isolated assigned eight serotypes by molecular serotyping, suggesting diverse Xinjiang. Phylogenetic analysis showed that...
Coxsackievirus A2 (CV-A2) has emerged as an important etiological agent in the hand, foot, and mouth disease herpangina pathogen spectrum because of its high global prevalence. In present study, we investigated evolutionary dynamics CV-A2 circulating China. We analyzed a total 163 entire VP1 sequences CV-A2, including 74 generated from study 89 collected GenBank database. Phylogenetic analysis based on nucleotide confirmed persistent circulation predominant genotype D mainland China since...
Nineteen CVA9 isolates were obtained between 2010 and 2019 from six provinces of mainland China, using the HFMD surveillance network established in China. Nucleotide sequencing revealed that full-length VP1 19 was 906 bases encoding 302 amino acids. The combination thresholds phylogenetic tree nucleotide divergence different genotypes within same serotype led to a value 15–25%, enabled worldwide be categorized into ten genotypes: A–J. showed prototype strain included genotype A, B, C, D, E,...