A5040892865- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Higher Education and Teaching Methods
- Respiratory viral infections research
- Virus-based gene therapy research
- Reliability and Maintenance Optimization
- Statistical Distribution Estimation and Applications
- China's Socioeconomic Reforms and Governance
- Herpesvirus Infections and Treatments
- Software Reliability and Analysis Research
- Animal Disease Management and Epidemiology
- Ideological and Political Education
- Poxvirus research and outbreaks
- RNA and protein synthesis mechanisms
- Bacillus and Francisella bacterial research
- Traditional Chinese Medicine Analysis
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Educational Reforms and Innovations
- Advanced Algorithms and Applications
- Probabilistic and Robust Engineering Design
- Immunotherapy and Immune Responses
- Evaluation and Optimization Models
- Viral Infections and Vectors
- Power Systems and Renewable Energy
Beijing Center for Disease Prevention and Control
2011-2024
Anhui University of Traditional Chinese Medicine
2018-2019
China University of Mining and Technology
2018
Dalian Polytechnic University
2018
Ministry of Industry and Information Technology
2016-2017
China Electronic Product Reliability and Environmental Test Institute
2017
Centers for Disease Control and Prevention
2011-2015
Chinese Center For Disease Control and Prevention
2012-2015
Beihang University
2014-2015
National Institute for Viral Disease Control and Prevention
2015
The first locally acquired case in the Chinese mainland was reported on May 31, 2023, lagging behind other countries. In this study, we aimed to examine early clinical and epidemiological characteristics of earliest cases Mpox Beijing, China. Additionally, investigated sequence transmission patterns virus (MPXV). We analyzed 37 Beijing from 2023 June 21, 2023. age range subjects 24-51 years. Thirty-six (97.3%) were identified men who have sex with (MSM), 19 (51.4%) tested positive for human...
Enterovirus 71 (EV71) is the most important causative agent of hand, foot and mouth disease (HFMD) in children. In cases, it a self-limiting illness. However some EV71 infectious cases can develop severe clinical outcomes, such as encephalitis, meningitis, poliomyelitis like paralysis, even death. To identify determinants virulence, deduced amino acid sequence polyprotein nucleotide 5′-NTR 3′-NTR 25 SC-EV71 strains (strains from cases) 31 MC-EV71 mild were analyzed. Results showed four acids...
Monkeypox (mpox) is a zoonotic disease caused by the mpox virus (MPXV) that has been primarily limited to Central and West African nations since its discovery. The recent spread of lineage MPXV in historically unaffected countries raised concerns for global public health. Despite significant decrease cases, there still risk resurgence. This study reports first local case an imported Chinese mainland. Polymerase chain reaction (PCR) diagnosed two viral genomes were obtained next-generation...
ABSTRACT The conventional hemagglutinin (HA)- and neuraminidase (NA)-based influenza vaccines need to be updated most years are ineffective if the glycoprotein HA of vaccine strains is a mismatch with that epidemic strain. Universal targeting conserved viral components might provide cross-protection thus complement improve vaccines. In this study, we generated DNA plasmids recombinant vaccinia viruses expressing proteins nucleoprotein (NP), polymerase basic 1 (PB1), matrix (M1) from virus...
Abstract Background Twelve students experienced symptoms of acute respiratory infection (ARI) at a training base in Beijing from August 26 to 30, 2015. We investigated the cause this ARI outbreak. Methods In partnership with local center for disease control, we collected total twelve pharyngeal swab specimens as well demographic information affected patients. used multiplex real-time PCR screen sixteen common viruses these samples. To isolate HAdV, inoculated Hep-2 cells human adenovirus...
Abstract Background Immunity to conserved viral antigens is an attractive approach develop a universal vaccine against epidemic and pandemic influenza. A nucleoprotein (NP)-based has been explored preliminary studies have shown promise. However, no study the immunity cross-protective efficacy of recombinant NP derived from Escherichia coli compared with vaccinia virus (Tiantan). Methods Recombinant protein (rNP) influenza A/Jingke/30/95(H3N2) was obtained E. (Tiantan) RVJ1175NP. Purified rNP...
Abstract Coxsackievirus A16 (CV‐A16) is a significant pathogen responsible for causing hand foot and mouth disease (HFMD) herpangina (HA). This study aimed to investigate the recent evolution spread of CV‐A16 by monitoring HFMD HA cases in 29 hospitals across 16 districts Beijing from 2019 2021. The first five each month hospital were included study. Real‐time reverse transcription polymerase chain reaction was used identify CV‐A16, CV‐A6, EV‐A71. From district, two four positive samples...
Abstract Coxsackievirus A16 (CV‐A16) is a significant etiologic agent of hand, foot, and mouth disease (HFMD) herpangina (HA), with the capacity to progress severe complications, including encephalitis, aseptic meningitis, acute flaccid paralysis, myocarditis, other critical conditions. Beijing's epidemiological surveillance system, established in 2008, encompasses 29 hospitals 16 district control centers. From 2019 2021, circulation CV‐A16 was characterized by co‐circulation B1a B1b clades....
Abstract Background: Huangqi is a famous Chinese medicinal material whose Dao-di producing area Hunyuan, Shanxi. produced in Shanxi, were divided into several different specifications and grades according to the diameters positions of root system. Objective: This article investigates quantitative characteristics chemical compositions Astragalus membranaceus var. mongholicus roots, aiming elucidate correlation between and/or Huangqi. Methods: Based on field investigation, samples collected...
Software faults could cause serious system errors and failures, leading to huge economic losses. But currently none of inspection verification technique is able find eliminate all software faults. testing an important way inspect these raise reliability, but obviously it a really expensive job. The estimation module’s fault-proneness minimize the resources required by guiding resource allocation on high-risk modules. Consequently efficiency reliability are improved. data sets, however,...
Abstract Background Enterovirus 71(EV71)-associated hand, foot and mouth disease (HFMD) decreased dramatically in Beijing from 2009 to 2019. This study was investigate the epidemiological characteristics, evolutionary dynamics, geographic diffusion pathway, other features of EV71 Beijing, China. Methods We conducted a retrospective EV71-associated HFMD its causative agent China, Phylogenetic phylogeographic methods based on genome were used determine evolution features, origin,...
Abstract The Daodi herb, Huangqi from Shanxi, is derived the root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao . was divided into different commercial specifications and grades in producing area according to macroscopic features. Developmental anatomy anomalous structure perennial fresh main A. investigated using conventional paraffin section explore relationship between classification results developmental showed that parenchyma cells secondary phloem xylem...
Condition based maintenance (CBM) is a practical and effective way to guarantee the product availability. Recent years optimization strategy of CBM widely studied by researchers. For with measurable degradation performance, modeling plays an important role in CBM. Inverse Gaussian process has many superb properties dealing covariates random effect. In this paper, new model developed basing on nonlinear inverse model. With constraint cost, optimal obtained maximizing availability product....
Accelerated degradation testing (ADT) is commonly used to obtain data under the hasher than normal usage conditions, and assess lifetime reliability for high reliable long life products in a short time. The optimal design ADT propose test plan based on performance process with reasonable criteria constraints of resources. Both traditional Bayesian are similar that historical needed determine initial values or prior distributions model parameters. However, it may be inaccurate estimate...
<abstract abstract-type="Abstract"> The first indigenous incidence of Mpox (previously known as monkeypox) within Chinese mainland was documented in May 2023, with subsequent local and imported cases identified. A comprehensive understanding the virus’s (MPXV) characteristics Beijing remains incomplete. In this study, 84 MPXV genomes from 82 incidents two instances, detected between July were analyzed. All strains fell lineage C.1 West African clade, displaying limited genetic heterogeneity,...
A life test sampling plan under accelerated condition is an efficient approach in reliability demonstration, especially for the products with high and long life. It pays more attention to rapid decision-making determining acceptance of a batch such that producer consumer risks are satisfied. Design depends on probability function parameters. The classical design method assumes parameters precise values. In practice, there uncertainty those Moreover, available prior knowledge, as history...
Abstract Background: Twelve students experienced symptoms of acute respiratory infection (ARI) at a training base in Beijing from August 26 to 30, 2015. We investigated the cause this ARI outbreak. Methods: In partnership with local center for disease control, we collected total twelve pharyngeal swab specimens as well demographic information affected patients. used multiplex real-time PCR screen sixteen common viruses these samples. To isolate HAdV, inoculated Hep-2 cells human adenovirus...