A5101894104- Hepatitis B Virus Studies
- Hepatitis C virus research
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Meningioma and schwannoma management
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Neurofibromatosis and Schwannoma Cases
- Congenital Heart Disease Studies
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Data-Driven Disease Surveillance
- Atherosclerosis and Cardiovascular Diseases
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Virus-based gene therapy research
Deyang Stomatological Hospital
2022-2025
Harbin Medical University
2011-2024
Second Affiliated Hospital of Harbin Medical University
2020-2024
China-Japan Friendship Hospital
2024
117th Hospital of People's Liberation Army
2024
Xian Yang Central Hospital
2019-2024
Early Warning (United States)
2024
Northwest A&F University
2024
Southwest Medical University
2024
Yang Hospital
2024
Background The association of genetic single-nucleotide polymorphisms (SNPs) related to endothelial function, inflammation, and their outcomes remains poorly studied. Objectives To evaluate the occurrence ischemic stroke (IS) other vascular events, relationships between 19 SNPs in genes associated with function inflammation a population at high risk stroke. Design A prospective cohort study multi-center community-based sectional survey. Methods As part China National Stroke Screening Survey...
The aim of this study was to characterize cervical microbiome feature reproductive-age women in the progression squamous intraepithelial lesions (SIL) cancer.We characterized 16S rDNA mucus 94 participants (age from 18 52), including 13 cancer (CA), 31 high-grade SIL (HSIL), 10 low-grade (LSIL), 12 HPV-infected (NH) patients and 28 healthy controls (NN). Alpha (within sample) diversity examined by Shannon Simpson index, while Beta (between principle coordinate analysis (PCoA) weighted...
Aim Evaluate the correlation between ischemic stroke and genetic variations related to inflammation endothelial function. Methods This was a multicenter cross-sectional research conducted in southwestern China. Residents aged ≥40 years voluntarily join face-to-face survey 8 communities. 2,377 participants were at high risk of stroke, which 429 had previous history stroke. We selected patients as subjects, adopted 1:1 matching method select healthy people with 2-year age difference same...
We sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among Hong Kong children.Patients <18 years of age who lived on Island (a separate island within Kong) and were admitted either only 2 public hospitals for a febrile acute respiratory 1 fixed day week in each hospital from October 2003 through September 2006 prospectively recruited. These together accounted 72.5% all general pediatric admissions known population denominator....
ABSTRACT The conventional hemagglutinin (HA)- and neuraminidase (NA)-based influenza vaccines need to be updated most years are ineffective if the glycoprotein HA of vaccine strains is a mismatch with that epidemic strain. Universal targeting conserved viral components might provide cross-protection thus complement improve vaccines. In this study, we generated DNA plasmids recombinant vaccinia viruses expressing proteins nucleoprotein (NP), polymerase basic 1 (PB1), matrix (M1) from virus...
Mutations in mitochondrial DNA (mtDNA) have been associated with hypertension several pedigrees maternal inheritance. However, the pathophysiology of maternally inherited remains poorly understood. We reported here clinical, genetic evaluations and molecular analysis mtDNA a three-generation Han Chinese family essential hypertension. Eight 17 matrilineal relatives exhibited wide range severity hypertension, whereas none offsprings affected father had The age-at-onset kindred varied from 31...
To investigate effects of radiotherapy on normal brain tissue using in vivo neuroimaging patients with nasopharyngeal carcinoma (NPC).We used longitudinal MRI to monitor structural changes during standard newly diagnosed NPC. We assessed volumetric measures 63 at 2-3 time points before and after radiotherapy, 20 NPC-free participants as controls. Images were processed validated software (FreeSurfer). Automated results inspected visually for accuracy. examined volume the whole brain, gray...
With the aging of population and change lifestyle in China, prevalence risk factors high-risk for stroke may change. However, few studies performed community-based surveys China. Hence, we this multicenter, cross-sectional, survey Sichuan southwestern according to China National Stroke Screening Survey (CNSSS) program 2015. The residents aged ≥ 40 years volunteered participate face-to-face 8 communities Sichuan. were selected using cluster randomization method. Subjects with at least three...
Objectives: To determine virologically confirmed hospitalization rates associated with respiratory syncytial virus (RSV), adenovirus, and parainfluenza viruses in Hong Kong children. Methods: All patients <18 years of age living on Island (within SAR) admitted for a febrile acute infection to 1 the 2 public hospitals fixed day week between October 2003 September 2006 were prospectively recruited. has known population denominator these managed 72.5% all general pediatric admissions this...
The induction of a robust neutralizing antibody (nAb) response is likely to be as essential specific cell-mediated immunity (CMI) against multiple antigens for the development effective preventive and therapeutic vaccines hepatitis C virus (HCV) infection in humans. To date, no data on immunogenicity replication-defective vaccinia (derived from Tiantan strain) (rNTV)-based HCV vaccine primates have been reported. This study describes detail various candidates rhesus macaques, including...
Abstract Objectives To identify the major complications independently associated with unfavorable outcomes in right‐sided large hemisphere infarction (RLHI) patients. Methods We retrospectively enrolled consecutive patients admitted within 24 h diagnosis of RLHI. The outcome was defined as a modified Rankin Scale score 4–6 at 3 months. Univariate and multivariate analyses were performed to 3‐month outcomes. Results Of 171 cases RLHI included, 126 (73.7%) had months: A total 64 (37.4%) died,...
A therapeutic vaccine for chronic hepatitis B virus (HBV) infection that enhances virus-specific cellular immune responses is urgently needed. The "prime-boost" regimen a widely used strategy against many persistence infections. However, few reports have addressed this applying HBV development.To develop an effective vaccine, we constructed recombinant vaccinia (Tiantan) containing the S+PreS1 fusion antigen (RVJSS1) combined with particle-like subunit HBVSS1 to explore most prime-boost HBV....
Background: Although mental fatigue was well-recognized as one of the long-term consequences following mild traumatic brain injury (MTBI) that required ongoing support, evidences for optimal management remained inadequate.Aims: To investigate temporal profile during first year after MTBI and examine impact perceived social support on recovery from post-MTBI fatigue.Study Design: Observational case-control study.Methods: This study conducted among patients admitted to emergency department in...
ABSTRACT To develop a novel, effective HBV therapeutic vaccine, we constructed two DNA immunogens that contained PreS1, HBSS1, and HBCS1. Several delivery methods, such as intramuscular (i.m.) injection, injection plus electroporation (i.m.-EP), intradermal (i.d.-EP) were used in murine model to analyze compare the immune responses induced by immunogens. We found i.d.-EP accelerated specific antibody seroconversion produced high (anti-PreS1, anti-S, anti-C antibody) titers after HBSS1 HBCS1...
Coinfusion of hematopoietic and mesenchymal stem cells is more effective than cell transplantation alone. It necessary to explore a safe routine mixed intraperitoneal method. Multiplacentas pooled were intraperitoneally injected into radiation‐ immunity‐induced mouse aplastic anemia model with single time. Then, survival time, peripheral blood hemoglobin count, bone marrow architecture, donor engraftment assessed. The recipient exhibited in both blood. Survival time count increased placenta...