A5101793647- Neurogenesis and neuroplasticity mechanisms
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Neuroinflammation and Neurodegeneration Mechanisms
- Dysphagia Assessment and Management
- Anesthesia and Neurotoxicity Research
- Axon Guidance and Neuronal Signaling
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Acupuncture Treatment Research Studies
- Cervical and Thoracic Myelopathy
- Neuroblastoma Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Myeloid Leukemia Research
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Protist diversity and phylogeny
- Cerebrospinal fluid and hydrocephalus
- RNA Research and Splicing
- Mesenchymal stem cell research
- Microtubule and mitosis dynamics
- Fetal and Pediatric Neurological Disorders
Fudan University
2005-2020
Shanghai Medical College of Fudan University
2015-2020
State Key Laboratory of Medical Neurobiology
2017-2020
Huashan Hospital
2005-2018
Objectives The changes of CSF flow dynamics in idiopathic normal pressure hydrocephalus (iNPH) are not fully elucidated. Most previous studies took the whole cardiac cycle as a unit. In this work, it is divided into systole and diastole phase compared between iNPH patients elderly paid special attention to change netflow direction. Materials methods Twenty according international guideline twenty healthy volunteers were included study examined by MRI. Three categories parameters measured:...
Promoting remyelination is crucial for patients with demyelinating diseases including multiple sclerosis. However, it still a circuitous conundrum finding practical remyelinating therapy. Electroacupuncture (EA), originating from traditional Chinese medicine (TCM), has been widely used to treat CNS all over the world, but role of EA in barely known. In this study, we examined properties and mechanisms cuprizone-induced model, murine model By feeding C57BL/6 mice chow containing 0.2%...
Electroacupuncture has been shown to promote remyelination in a demyelinating model of multiple sclerosis (MS) through enhanced microglial clearance degraded myelin debris. However, the mechanisms involved this process are yet be clearly elucidated. It revealed that TAM receptor tyrosine kinases (Tyro3, Axl, and MerTK) play pivotal roles regulating features microglia, including phagocytic function clearance. Therefore, aim study is further confirm whether electroacupuncture improves...
Objective To explore the therapeutic results of deferoxamine in treatment spontaneous intracerebral hemorrhage (SICH).Methods A total 29 patients were collected from 4 clinical centers Shanghai and Ningbo City.Nineteen cases received as group,and l0 routine therapy control group.Deferoxamine was given after onset stroke for a consecutive 3 days.All had brain MRI T2WI T2 * WI scanning at 1st,7th 14th days onset.The image features recorded analysis performed by software Image J.The...
Objective . The Notch signaling pathway is involved in angiogenesis induced by brain ischemia and can be efficiently inhibited the γ -secretase inhibitor N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT). aim of present study was to noninvasively investigate effect DAPT treatment on repair after stroke using magnetic resonance imaging (MRI). Methods Sprague-Dawley rats (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
To explore the mechanism of electroacupuncture (EA) in accelerating aggregation microglia and promoting remyelination at location demyelination.C57BL/6 mice were randomly divided into 4 groups: normal, control, model (LPC) LPC＋EA. The demyelination was established by microinjection Lysolecithin (LPC, 1 µL) left corpus callosum. EA (2 Hz/15 Hz, 2－4 mA) applied to "Baihui"(GV20)and "Zhiyang"(GV9)for 30 min，once daily for 3 days, then, once every other day 18 days. Immuno-fluorescence staining...