A5028528726- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Bone Tumor Diagnosis and Treatments
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Cancer Immunotherapy and Biomarkers
- IgG4-Related and Inflammatory Diseases
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Ovarian function and disorders
- Antifungal resistance and susceptibility
- Ion Transport and Channel Regulation
- Hydrogen's biological and therapeutic effects
- Facial Nerve Paralysis Treatment and Research
- Actinomycetales infections and treatment
Fudan University
2012-2025
Huashan Hospital
2012-2025
Shanghai Clinical Research Center
2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2023
Harvard University
2023
Jiangxi Transportation Research Institute
2022
Weifang Medical University
2012-2021
Lanzhou University
2021
Lanzhou University Second Hospital
2021
Commercial Aircraft Corporation of China (China)
2019
Abstract Background Ferroptosis, a programmed cell death characterized by lipid peroxidation, is implicated in various diseases including cancer. Although density-dependent E-cadherin and Merlin/Neurofibromin (NF2) loss can modulate ferroptosis, the role of ferroptosis its potential link to NF2 status expression meningioma remain unknown. Methods Relationship between modulators mutational was examined 35 meningiomas (10 25 wild type). The impact on were lactate dehydrogenase (LDH) release,...
Molecular mechanisms underlying the pathogenesis of meningioma are not fully elucidated. In this study, we established differential gene expression profiles between meningiomas and brain arachnoidal tissue by using Affymetrix GeneChip Human U133 Plus 2.0 Array. KEGG pathway analysis demonstrated that PI3K/Akt TGFβ signaling pathways were up-regulated in fibroblastic meningioma, focal adhesion ECM-receptor interaction activated anaplastic meningioma. EGFL6 was one most genes microarray...
Background Meningioma is one of the most common primary tumors central nervous system, but there are not many detailed studies on sex, age, subtypes and locations large series. This study was a retrospective analysis characteristics meningioma cases consecutively operated at single institution in China from 2001 to 2010. Methods investigated demographic background 7084 cases, tumors. Sex age distributions were analyzed, pathological classified according World Health Organization (WHO)...
Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis these cases.15 patients underwent surgical treatment for intracranial between 2001 2010 at Neurosurgery Department Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, strategy, pathological findings all were...
Owing to lack of appropriate model systems, investigations meningioma biology have come a stop. In this study, we developed comprehensive digestion method and defined culture system. Using system, primary cells in conditioned suspension medium hypoxic environment could be amplified spheres were passaged for more than ten generations. Meningioma sphere positive cell markers negative neural types. Importantly, found the expressed stem marker, CD133, but not nestin. All tumor populations showed...
Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due their complicated anatomy structures adjacent vessels. It's essential locate the tumor its vessels precisely during operation reduce risk of neurological deficits. The purpose this study was evaluate intraoperative ultrasonography in displaying intracranial meningioma surrounding arteries, potential improve surgical precision minimize trauma.Between December 2011...
Chordoid meningioma (CM), characterized by its resemblance to chordoma, was first described Kepes et al1 in 1988, and classified histologically as a WHO grade II neoplasm the 2000 revision of grading system, featured aggressive clinical course, great risk recurrence, infrequent association with hematological conditions.2 This article describes radiological characteristics, postoperative treatment, prognosis 17 patients CM who underwent surgical treatment at our hospital. METHODS Seventeen...
Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection.Ten patients with anterior, middle and sphenoid ridge meningioma were operated using system at Neurosurgery Department Shanghai Huashan Hospital from August 2014 to October 2014. There six male four female patients, aged 38 61 years old (the mean age 48.5 old). Five cases tumor located...
Abstract Background Meningiomas with Neurofibromin 2 gene mutations (NF2-mutant meningiomas) account for ~40% of the sporadic meningiomas. However, there is still no effective drug treatment disease. Methods Expression profile Merlin protein was explored through immunohistochemistry in a meningioma patient cohort (n = 346). A 20-agent library covering wide range relevant targets tested using cell lines IOMM-Lee (NF2 wildtype) and CH157-MN deficient). Therapeutic effects biological mechanisms...
OBJECTIVE Psammomatous meningiomas (PMs) are a rare histological subtype of meningioma but rather frequent in spinal meningiomas. The authors aimed to analyze the incidence, clinical features, molecular alterations, long-term outcomes, and prognostic factors PMs. METHODS In total, 151 patients with PMs were included this study. Clinical characteristics, progression-free survival (PFS) analyzed characteristics compared between other WHO grade 1 Targeted sequencing meningioma-relevant genes...
Yaodong Ding, Yu Ge, Daijun Wang, Qin Liu, Shuchen Sun, Lingyang Hua, Jiaojiao Deng, Shihai Luan, Haixia Cheng, Qing Xie, Ye Gong, and Tao Zhang. Mol. Cells 2022;45:388-402. https://doi.org/10.14348/molcells.2022.2232