A5054540982- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Genomics and Rare Diseases
- interferon and immune responses
- Antimicrobial Resistance in Staphylococcus
- Animal Disease Management and Epidemiology
- Metabolism and Genetic Disorders
- Neonatal and Maternal Infections
- Immunodeficiency and Autoimmune Disorders
- Congenital heart defects research
- Infective Endocarditis Diagnosis and Management
- Otolaryngology and Infectious Diseases
- Viral Infections and Vectors
- Blood disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Genomic variations and chromosomal abnormalities
- Neuroblastoma Research and Treatments
- Gut microbiota and health
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- Neurogenetic and Muscular Disorders Research
- Pneumonia and Respiratory Infections
- Geotechnical and Geomechanical Engineering
Beijing Center for Disease Prevention and Control
2012-2025
Jiangxi University of Science and Technology
2025
Shijiazhuang Tiedao University
2025
Sun Yat-sen Memorial Hospital
2022-2024
Sun Yat-sen University
2022-2024
Hunan Children's Hospital
2024
Children's Hospital of Fudan University
2017-2023
Chizhou University
2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2022
Guangxi University
2021-2022
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, significantly contributes to cancer-related mortality, presenting a dearth of efficacious treatment strategies. Previously, our studies have substantiated potent cytotoxicity arsenic trioxide (ATO) against NB cells, however, specific underlying mechanism remains elusive. Here, we first identified ATO as novel GPX4 inhibitor, which could trigger ferroptosis cells. In vitro, inhibited proliferation and migration ability...
<title>Abstract</title> <italic>Streptococcus pyogenes</italic> infections such as scarlet fever have increased in China since 2011. The genomic drivers of this increase are not known. temporal clonal shifts within dominant <italic>emm12</italic> and <italic>emm1</italic> populations unknown due to limited sampling. Based on a large longitudinal strain collection, we aimed describe the molecular epidemiological characteristics population structure <italic>S. pyogenesemm</italic> types...
ABSTRACT Extracting gas from low‐permeability coal seams is essential for mine safety and efficiency. To address this challenge, a novel technique combining hydraulic fracturing dissolution was proposed. The feasibility of method verified through simulations based on the distinct element method. Subsequently, impact weakened mechanical properties (deformation strength) fracture propagation analyzed. Finally, possibility controlling non‐uniform fractures treatment parameters discussed....
Scarlet fever is one of a variety diseases caused by group A Streptococcus (GAS). During 2011, scarlet epidemic characterized peak monthly incidence rates 2.9-6.7 times higher than those in 2006-2010 occurred Beijing, China. the epidemic, hospital-based enhanced surveillance for and pharyngitis was conducted to determine characteristics circulating GAS strains. The identified 3,359 clinical cases or pharyngitis. isolated from 647 patients; 76.4% strains were type emm12, 17.1% emm1. Almost...
Severe acute respiratory infection (SARI) threatens human health and even survival, causing a huge number of hospitalized patients every year. However, as one the most common viruses circulated worldwide, epidemiological phylogenetic characteristics parainfluenza virus (HPIV) in these cases were not well known.To reveal features HPIV SARIs Beijing area from September 2014 to August 2016.A total 1229 SARI enrolled, investigated, sampled, tested by multiplex real-time PCR identify HPIVs other...
Abstract Emerging evidence demonstrates the clinical utility of genomic applications in newborn intensive care unit (NICU) patients with strong indications Mendelian etiology. However, such applications' diagnostic yield and remain unclear for NICU cohorts minimal phenotype selection. In this study, focused medical exome sequencing was used as a first‐tier, singleton‐focused tool 2303 unrelated sick neonates. Integrated analysis single nucleotide variants (SNVs), small insertions deletions...
Multiple congenital anomalies (MCAs) at birth have emerged as an important cause of neonatal morbidity and mortality. This study aimed to investigate the genetic causes characteristics clinical outcomes in a large cohort neonates with MCAs. Clinical exome sequencing/exome sequencing/genome sequencing were undertaken from December 1, 2016 2019 detect single nucleotide variations (SNVs) copy number (CNVs) simultaneously individuals who met inclusion criteria. A total 588 MCAs enrolled. One...
The continued spread of highly pathogenic avian influenza (HPAI) viruses H5 and H7 subtypes low (LPAI) H5, H9 in birds the subsequent infections humans pose an ongoing pandemic threat. It has been proposed that poultry workers are at higher risk exposure to HPAI or LPAI subsequently infection due their repeated chickens domestic waterfowl. aim this study was examine seroprevalence antibodies against amongst duck-related Beijing, China factors associated with seropositivity. In March, 2011,...
Background: Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and it involves host's immune response against multiple viruses. IFITM3 rs12252-C was associated with severe influenza virus infection several studies, however whether this association universal to all types of or diverse ethnic populations remain controversial. Method: A case-control genetic study performed from September 2013 April 2014 2015. All samples were tested for using RT-PCR, genotyped...
Abstract Background Twelve students experienced symptoms of acute respiratory infection (ARI) at a training base in Beijing from August 26 to 30, 2015. We investigated the cause this ARI outbreak. Methods In partnership with local center for disease control, we collected total twelve pharyngeal swab specimens as well demographic information affected patients. used multiplex real-time PCR screen sixteen common viruses these samples. To isolate HAdV, inoculated Hep-2 cells human adenovirus...
The protective effects of Caulis Spatholobi polysaccharide (CSP) on immune function, intestinal mucosal barrier, and microflora in cyclophosphamide (CY)-induced immunosuppressed chickens have been rarely reported. This study was designed to investigate the cecal microbiota elucidate mechanism involved CSP effect CY induced-immunosuppressed chickens. A total 288 cocks were equally divided into six groups used evaluate CSP. Results showed that increased body weight organ index chickens,...
Abstract Objective We aimed to use next‐generation sequencing (NGS) for the early diagnosis of primary immunodeficiency diseases (PIDs) and define its effects on medical management an infant cohort in life. Methods A single‐centre study was conducted from November 2015 April 2018. Infants less than 3 months old with infections or abnormal white blood cell counts were enrolled study. Gene variants analysed by NGS, once a mutation found PID‐associated gene, immune functions associated this...
Craniosynostosis is a premature fusion of cranial sutures, resulting in abnormally shaped skull and brain development disorder. The description craniosynostosis patients with BCL11B mutations rare. Here, we firstly report 25-month-old Chinese boy novel frameshift variant gene. patient was identified c.2346_2361del by whole-exome sequencing confirmed to be de novo parental Sanger sequencing. This presented clinical phenotype as well global developmental delay. He had small mouth, thin upper...
Although several studies have reported seroprevalences of antibody against avian influenza A(H7N9) virus among poultry workers in southern China, results varied and data northern China are scarce. To understand risks H7N9 H5N1 infections a serological cohort study was conducted. Poultry workers, swine the general population Beijing, were evaluated through three surveys November 2013, April 2014 2015. The highest seroprevalence to recorded 2015 (0.4%), while that clade 2.3.4 or 2.3.2.1 noted...
Effects of a high-rice dietary proportion on the meat quality, acute phase reaction proteins (APRPs) and colonic microbiota metabolites in goats are rarely reported. This study was designed to investigate quality metabolism goats. Sixteen were equally divided into two groups fed control diet (Con, 55% concentrate) or (HR, 90% for five weeks. We found that HR improved slaughtering characteristic but induced an decreased bacterial richness diversity when compared group. Furthermore, levels...
Background Congenital heart defects (CHDs) are the most common type of birth defects. The genetic aetiology CHD is complex and incompletely understood. overall distribution causes in patients with from neonatal intensive care units (NICUs) needs to be studied. Methods cases were extracted China Neonatal Genomes Project (2016–2021). Next-generation sequencing results medical records retrospectively evaluated note frequency diagnosis respective patient outcomes. Results In total, 1795...
During surveillance for pneumonia of unknown etiology and sentinel hospital-based in Beijing, China, we detected avian influenza A(H7N9) virus infection 4 persons who had pneumonia, influenza-like illness, or asymptomatic infections. Samples from poultry workers, associated environments, wild birds suggest that this might not be present Beijing.
Serfling-type periodic regression models have been widely used to identify and analyse epidemic of influenza. In these approaches, the baseline is traditionally determined using cleaned historical non-epidemic data. However, we found that previous exclusion seasons was empirical, since year-year variations in seasonal pattern activity had ignored. Therefore, excluding fixed 'epidemic' months did not seem reasonable. We made some adjustments rule epidemic-period removal avoid potentially...
Background Treatment for parameningeal rhabdomyosarcoma (PM-RMS) has been a challenge since local control is difficult. The goal of this study was to analyse the impact different treatment approaches on childhood PM-RMS patients and help dispel doubt that whether secondary radical surgery (SRS) should be encouraged in management PM-RMS. Methods A total 17 children with who received unified systemic chemotherapy individualized therapy such as radiotherapy (RT) and/or SRS were included...