A5101396914- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Teratomas and Epidermoid Cysts
- Infant Nutrition and Health
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Congenital gastrointestinal and neural anomalies
- Congenital Diaphragmatic Hernia Studies
- Head and Neck Anomalies
- Neonatal Respiratory Health Research
- Gallbladder and Bile Duct Disorders
- Esophageal Cancer Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Cleft Lip and Palate Research
- Congenital heart defects research
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Impact on Reproduction
- Clinical Nutrition and Gastroenterology
- Neonatal Health and Biochemistry
- Vascular Malformations and Hemangiomas
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
Guangzhou University of Chinese Medicine
2025
Children's Hospital of Fudan University
2014-2024
Cangzhou Central Hospital
2023
Shanghai Children's Medical Center
2019-2022
Boston Children's Hospital
2015
Fudan University
2013
Xi'an Jiaotong University
2008
Jiawei Shoutai Pill is a traditional Chinese medicine formulation used clinically by physicians to treat diminished ovarian reserve (DOR) with positive outcomes. This study aimed explore the potential pharmacological mechanisms of in treating DOR using network pharmacology methods. The effective compounds from were collected TCMSP, SYMmap, and PubChem, corresponding targets retrieved Swiss Target Prediction, DrugBank. Additionally, for obtained GeneCards Online Mendelian Inheritance Man...
Multiple congenital anomalies (MCAs) at birth have emerged as an important cause of neonatal morbidity and mortality. This study aimed to investigate the genetic causes characteristics clinical outcomes in a large cohort neonates with MCAs. Clinical exome sequencing/exome sequencing/genome sequencing were undertaken from December 1, 2016 2019 detect single nucleotide variations (SNVs) copy number (CNVs) simultaneously individuals who met inclusion criteria. A total 588 MCAs enrolled. One...
Abstract Objectives To explore the clinical characteristics, postnatal treatment and prognosis of giant fetal hepatic hemangioma (GFHH). Method Retrospective analysis was performed on children with (maximum tumor diameter > 40 mm) diagnosed by prenatal ultrasound MRI from December 2016 to 2020. These patients were observed treated at Children’s Hospital Fudan University after birth. The data collected analyze treatment, GFHH using independent sample t tests or Fisher’s exact tests....
Objective To investigate health-related quality of life (HRQOL) in patients after surgical repair for esophageal atresia (EA) and identify its potential influencing factors. Methods A total 102 EA children who had previously visited our hospital participated this cross-sectional study. Basic data disease the were collected. The HRQOL was measured with Pediatric Quality Life Inventory ™ 4.0 (PedsQL 4.0) EA-QOL questionnaire ranked on a reverse 0–100 scale, higher number indicative better...
Biliary atresia (BA) is a devastating disease of infants, invariably leading to cirrhosis, end-stage liver disease, and death if untreated. The etiology BA unknown, although infectious, immune, genetic causes have been suggested. This study was designed investigate whether polymorphism the ITGB2 (CD18) gene associated with susceptibility BA.The promoter 16 exons were genotyped following amplification sequencing, associations assessed using Fischer's exact test in 106 patients diagnosed 108...
Background: Laparoscopic repair has become the preferred option for treatment of pediatric hernias. Recently, laparoscopic operations have also been conducted in recurrent hernia cases. percutaneous extraperitoneal closure (LPEC) is a simple and reliable minimally invasive procedure inguinal repair. However, it still unclear whether LPEC an ideal hernias children. The aim this study to evaluate efficacy Patients Methods: We retrospectively reviewed all children with primary repairs our...
Background: The aim of the study was to employ a combination radiomic indicators based on computed tomography (CT) imaging and machine learning (ML), along with deep (DL), differentiate between adrenal hematoma neuroblastoma in neonates. Methods: A total 76 neonates were included this retrospective (40 neuroblastomas 36 hematomas) who underwent CT divided into training group (n?=?38) testing (n?=?38). regions interest (ROIs) segmented by two radiologists extract radiomics features using...
Biliary atresia (BA) is a devastating cholestatic liver disease targeting infants. Current diagnosis depends on surgical exploration of the biliary tree. The aim present study was to identify potential biomarkers for (BA). Two-dimensional electrophoresis utilized identification proteins that were differentially expressed in biopsies 20 BA patients and 12 infants with non-BA neonatal cholestasis (NC) as controls. Using mass spectrometry, we identified 15 expressions significantly altered. Out...
Hirschsprung's disease (HSCR) is a congenital digestive tract malformation characterized by the absence of intramural ganglion cells in myenteric and submucosal plexuses along variable lengths gastrointestinal tract. Although improvement surgical methods has allowed great progress treatment HSCR, its incidence postoperative prognosis are still not ideal. The pathogenesis HSCR remains unclear to date. In this study, metabolomic profiling serum samples was performed an integrated analysis gas...
Hao, J., Sun, L., Huang, H., Xiong, G., Liu, X., Qiu, Chen, Dong, B., Li, Y., W., Buechler, Shen, C. and Luo, Q. Effects of Recombinant Human Interleukin 11 on Thrombocytopenia Neutropenia in Irradiated Rhesus Monkeys. Radiat. Res. 162, 157–163 (2004).The effects recombinant human interleukin (rhIL11) thrombocytopenia neutropenia irradiated rhesus monkeys were evaluated after administration different doses at times. Twenty-three exposed to a total-body irradiation (TBI) with single dose 3 Gy...
Objective: To compare the effects of hepatic portocholecystostomy (HPC) and Kasai procedure for treatment biliary atresia with patent distal extrahepatic bile ducts (BA PDEBD) to determine reasons differences between two procedures. Methods: The case files 29 patients BA PDEBD were reviewed retrospectively. Twenty treated procedure, 9 HPC. We compared rate jaundice clearance, incidence cholangitis, survival rates native liver, clinical outcomes groups. Healthy gallbladders collected...