A5101949995- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Health and Biochemistry
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Sensors and Ion Detection
- Natural Language Processing Techniques
- Topic Modeling
- Sulfur Compounds in Biology
- Dialysis and Renal Disease Management
- Gastroesophageal reflux and treatments
- Liver physiology and pathology
- Explainable Artificial Intelligence (XAI)
- Analytical Chemistry and Sensors
- Intensive Care Unit Cognitive Disorders
- Nitric Oxide and Endothelin Effects
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Smart Grid and Power Systems
- Congenital Diaphragmatic Hernia Studies
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
Nanjing Medical University
2021-2025
Huashan Hospital
2024
Children's Hospital of Fudan University
2015-2024
Xingtai People's Hospital
2024
Huazhong University of Science and Technology
2024
Hebei Medical University
2024
Dalian University of Technology
2024
Fudan University
2021-2023
East China University of Science and Technology
2023
Jiangsu University of Science and Technology
2023
Abstract Background Observational studies have suggested a suspected association between gastroesophageal reflux disease (GERD) and respiratory diseases, but the causality remains equivocal. The goal of this study was to evaluate causal role GERD in diseases by employing Mendelian randomization (MR) studies. Methods We conducted analysis based on summary data genome-wide (GWASs) three MR statistical techniques (inverse variance weighted, weighted median MR-Egger) were employed assess...
Biliary atresia (BA) is a congenital cholestatic disease that can seriously damage children’s liver function. It one of the main reasons for transplantation in children. Early diagnosis BA crucial to prognosis patients, but there still lack reliable non-invasive diagnostic methods. Additionally, as some children are urgent need transplantation, evaluating stage fibrosis and postoperative native survival with using straightforward, efficient, less traumatic method major focus doctors. In...
AIM:To compare the prevalence and diversity of gastrointestinal (GI) symptoms in patients undergoing peritoneal dialysis (PD) hemodialysis (HD). METHODS:Two hundred ninety-four end-stage renal disease participated study, including 182 HD 112 PD patients.Dimension scores were calculated from a modified symptom rating scale (GSRS) 18-item questionnaire, items concerning eating dysfunction, used for measuring GI symptoms.Information on patient age, condition contributing to most recent adequacy...
The aim of the study was to analyze value gamma-glutamyl transpeptidase (GGT) for distinguishing biliary atresia (BA) from non-BA patients suspected having neonatal obstructive jaundice by correlation with age.From January 2003 March 2014, cholangiography and/or surgical exploration were undertaken in 1469 suspicion jaundice. A total 1338 diagnosed BA intraoperatively. Preoperative medical records compared between and patients.Preoperative levels bilirubin, direct GGT significantly higher...
Background & aimsThe overlapping features of biliary atresia (BA) and the other forms neonatal cholestasis (NC) with different causes (non-BA) has posed challenges for diagnosis BA. This study aimed at developing new better diagnostic models BA.MethodsWe retrospectively analyzed data from 1728 newborn infants obstructive jaundice (NOJ). New prediction models, including decision tree (DT), random forest (RF), multivariate logistic regression-based nomogram BA were created externally validated...
Thyroid carcinoma is the most common endocrine malignancy and a cancer among malignancies of head neck. Noninvasive convenient biomarkers for diagnosis papillary thyroid (PTC) as early possible remain an urgent need. The aim this study was to discover identify potential protein PTC specifically.Two hundred twenty four (224) serum samples with 108 116 controls were randomly divided into training set blind testing set. Serum proteomic profiles analyzed using SELDI-TOF-MS. Candidate purified by...
The effects of the calcium channel blocking agent, verapamil, were studied in a murine model viral myocarditis. Three groups 8-wk-old DBA/2 mice (n = 25 each) inoculated with 10 plaque-forming units encephalomyocarditis virus and randomized to three treatment regimens. Group 1 received verapamil intraperitoneally (5 mg/kg per d) for 7 d before infection, followed by orally (mean dose 3.5 mg/mouse drinking water during infection. 2 only starting on day 4 after coincident peak viremia. 3...
To investigate the surveillance trend of birth defects, incidence, distribution, occurrence regularity, and their relevant factors in Xi'an City last 10 years for proposing control measures.The defects monitoring data infants during perinatal period (28 weeks gestation to 7 days after birth) were collected from obstetrics departments all hospitals 2003-2012. Microsoft Excel 2003 was used input, Statistical Package Social Sciences version 16.0 (International Business Machines Corporation, New...
Abstract Background and Aim Biliary atresia (BA) is a progressive fibro‐inflammatory cholangiopathy with an unclear etiology. Various liver disorders are associated altered microbiome. However, gut microbiome in BA remains unknown. Here, we performed case‐control study to investigate the microbiota BA. Methods A cross‐sectional analysis was first conducted for 34 patients healthy controls. Then investigated shift 2 weeks after Kasai procedure 16 patients. Gut initially analyzed using 16S...
This study aimed to analyze the impact of etiologic heterogeneity and operation age on prognosis infants with biliary atresia (BA) who received Kasai prior 60 days age. From 2004 2010, 158 before turning old. According Davenport 2012 classifications, 4 groups BA were defined: cystic BA, syndrome associated malformation, cytomegalovirus (CMV)-associated isolated BA. Native (autologous) liver survival rates incidence cholangitis 2 years after operation, as well jaundice clearance 3 months...
Abstract The reaction kinetics and molecular mechanisms of CO 2 absorption using nonaqueous aqueous monoethanolamine (MEA)/methyldiethanolamine (MDEA)/2‐amino‐2‐methy‐1‐propanol (AMP) solutions were analyzed by the stopped‐flow technique ab initio dynamics (AIMD) simulations. Pseudo first‐order rate constants ( k 0 ) reactions between amines measured. A kinetic model was proposed to correlate amine concentration, proved perform well for predicting relationship concentration. experimental...
To investigate whether protein induced by vitamin K antagonist-II (PIVKA-II) combined with alpha-fetoprotein (AFP) can improve the diagnostic and differential accuracy of childhood hepatic tumors. A multi-center prospective observational study was performed at nine regional institutions around China. Children mass (Group T) were divided into hepatoblastoma group THB) hemangioendothelioma THE), children extrahepatic abdominal C). Peripheral blood collected from each patient prior to surgery...
Danilo Neves Ribeiro, Shen Wang, Xiaofei Ma, Rui Dong, Xiaokai Wei, Henghui Zhu, Xinchi Chen, Peng Xu, Zhiheng Huang, Andrew Arnold, Dan Roth. Findings of the Association for Computational Linguistics: NAACL 2022.
ABSTRACT Objective: The mechanisms responsible for increased collagen production and hepatic fibrosis in biliary atresia (BA) remain largely unknown. We evaluated α‐smooth muscle actin (α‐SMA) expression liver the porta hepatis infants with BA. Methods: Immunohistochemical staining α‐SMA CD68 BA was performed. A semiquantitative 3‐grade staging system employed to estimate fibrosis. densities of levels direct bilirubin were assessed relation expression. Results: found be overexpressed...
AIM:To investigate gastrointestinal (GI) symptoms in peritoneal dialysis (PD) patients and to explore related factors contributing GI symptoms. METHODS:One hundred twelve undergoing PD participated the study.The symptom rating scale was used for measuring symptoms.Information on age, height, weight, body mass index, disease leading chronic renal failure, history of corticosteroid therapy, presence predialytic symptoms, daily dosage pills, duration, type dialysate volume obtained by...
Objective . The dosage, duration, and the benefits of high-dose steroid treatment outcome in biliary atresia (BA) remain controversial. In this study, we evaluated impact therapy on BA after Kasai procedure. Methods. Intravenous prednisolone administration was started 1 week surgery, followed by 8 to 12 weeks oral prednisolone. Total bilirubin (TB) levels (3, 6, months surgery), early onset cholangitis, two-year native liver survival were evaluated. Results. 53.4%, 56.9%, 58.1% patients...
Abstract To investigate the mechanism of 25 hydroxyvitamin D (25(OH)D) deficiency in children with biliary atresia (BA) and its effect on liver fibrosis. The serum vitamin 25(OH)D, expression hydroxylase (CYP2R1 CYP27A1) BA patients were detected compared those control group. We investigated differential CYP2R1 hepatocytes genes related to fibrosis primary hepatic stellate cells (HSCs) animal models cholestasis. ratio 25(OH)D/vitamin group was significantly lower than that mRNA protein...