A5107845086- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Berberine and alkaloids research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Psoriasis: Treatment and Pathogenesis
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Hepatocellular Carcinoma Treatment and Prognosis
- Hippo pathway signaling and YAP/TAZ
- Gastrointestinal motility and disorders
- Extracellular vesicles in disease
- Testicular diseases and treatments
- T-cell and B-cell Immunology
- Therapeutic Uses of Natural Elements
- Genetic and Kidney Cyst Diseases
The 309th Hospital of Chinese People's Liberation Army
2025
Shanghai Children's Medical Center
2017-2025
Shanghai Jiao Tong University
2017-2025
Shanghai Medical College of Fudan University
2024
Shanghai Clinical Research Center
2021-2024
Guiyang Medical University
2024
Sanya City Women and Children Hospital
2024
Tongji University
2013-2020
Shanghai Tenth People's Hospital
2013-2020
We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS‐D) receiving berberine hydrochloride a randomized double‐blind placebo‐controlled trial. Overall, 196 patients with IBS‐D were recruited for this study; consequently, 132 receive daily 400 mg of hydrochloride, delivered twice or placebo 8 weeks followed by 4‐week washout period. After 2‐week run‐in period, diarrhea, abdominal pain, urgent need defecation frequency and any adverse events recorded...
Background and Aims Berberine its derivatives display potent analgesic, anti-inflammatory anticancer activity. Here we aimed at characterizing the mechanism of action berberine in gastrointestinal (GI) tract cortical neurons using animal models vitro tests. Methods The effect was characterized murine mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then opioidantagonists were used to identify receptors involved. Furthermore, berberineon opioid expression established...
Hepatoblastoma (HB) is the predominant hepatic malignancy among children. Despite therapeutic options for HB were gradually refined in recent years, patients with metastasis suffer from an unsatisfactory prognosis. Pyroptosis a type of programmed and inflammatory necrosis. Neutrophils are crucial innate immunity, which shown to be associated tumor progression. Our study strived unravel relationship between neutrophil-induced pyroptosis (NIP) HB. The clinical bulk RNA sequencing data 38...
MicroRNAs have been reported to play critical roles in various cancers, but there has no study on the role of miR‐889 cancers. Here, we report that over‐expression leads rapid proliferation EC109 and EC9706 cells vitro vivo by inducing into S‐phase. Using bioinformatics methods, DAB2IP was further confirmed be a direct target miR‐889. In addition, expression DAB2IP, which negatively correlated with miR‐889, significantly associated clinicopathological features ESCC patients. conclusion, is...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation immune evasion. Herein, it demonstrated that tripartite motif 65 (TRIM65) E3 ubiquitin-protein ligase, O-GlcNAcylated via O-GlcNAcylation transferase, highly expressed facilitated metabolic remodeling to accumulation products related uracil palmitic acid, driving progression HCC. Mechanistically,...
Hepatic ischemia-reperfusion (I/R) injury contributes to hepatic dysfunction and failure after liver transplantation, major resection, trauma, hypovolemic shock. Therefore, reducing I/R is an important goal improve the outcome of these procedures. Recently, high-mobility group box 1 protein (HMGB1) has been identified as a pathogenic mediator in several inflammatory diseases, including I/R. PNU-282987, selective α7 nicotinic acetylcholine receptor agonist, prevents nuclear factor κB (NF-κB)...
To investigate whether protein induced by vitamin K antagonist-II (PIVKA-II) combined with alpha-fetoprotein (AFP) can improve the diagnostic and differential accuracy of childhood hepatic tumors. A multi-center prospective observational study was performed at nine regional institutions around China. Children mass (Group T) were divided into hepatoblastoma group THB) hemangioendothelioma THE), children extrahepatic abdominal C). Peripheral blood collected from each patient prior to surgery...
Osteoblast differentiation is a pivotal event in bone formation. Runt-related transcription factor-2 (Runx2) an essential factor required for osteoblast and However, the underlying mechanism of Runx2-regulated osteogenic still unclear. Here, we explored corresponding using C2C12/Runx2Dox subline, which expresses Runx2 response to doxycycline (Dox). We found that Runx2-induced C2C12 cells results sustained decrease expression heparin-binding EGF-like growth (HB-EGF), member epidermal (EGF)...
The runt-related transcription factor 2 (Runx2) is a cell-fate-determining that controls osteoblast differentiation and bone formation. It has been previously demonstrated microRNAs (miRNAs) play important roles in osteogenesis. However, the Runx2-regulated miRNAs have reported thus far are limited. In this study, we pursued to identify these Tet-on stable C2C12 cell line (C2C12/Runx2(Dox) subline). Microarray analysis revealed alterations miRNA expression occur with 54 miRNAs. Among miRNAs,...
ING3, a member of the inhibitor growth (ING) family, has been reported to be involved in transcription modulation, cell cycle control and induction apoptosis. Previous studies have demonstrated that expression ING3 decreased melanoma head neck squamous carcinoma (HNSCC). The aim this study was investigate role hepatocellular (HCC) tumorigenesis progression. correlation between clinicopathological variables HCC analyzed. Using real-time reverse transcription-polymerase chain reaction...
IL-27 is an anti-inflammatory cytokine that triggers enhanced antitumor immunity, particularly cytotoxic T lymphocyte responses. In the present study, we sought to develop into a therapeutic adjutant for adoptive cell therapy using our well-established models. We have found directly improved survival status and cytotoxicity of OT-1 CD8+ cells in vitro vivo. Meanwhile, treatment programs memory differentiation cells, characterized by upregulation genes associated with (T-bet, Eomes, Blimp1,...
Pneumonia is the leading cause of death in young children globally. However, underlying pathological mechanism pediatric pneumonia remains unclear. In infection disease contexts, small extracellular vesicles (sEVs) have been shown to be a useful source markers for pathogenesis and immune response. We hypothesized that functional molecules such as protein harbored by sEVs would provide mechanistic insights into response with pneumonia.We isolated from serum collected without pneumonia,...
Abstract: Previous studies have suggested that macrophage migration inhibitory factor (MIF) -173G/C polymorphism may be associated with cancer risk. However, previous research has demonstrated conflicting results. Therefore, we followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines meta-analysis on genetic association checklist, performed a to investigate between MIF polymorphisms risk of cancer. Odds ratios (ORs) corresponding 95% confidence...
Functional imaging (FI) techniques have revolutionized tumor by providing information on specific functions, such as glycometabolism. However, cells lack unique molecular characteristics at the level and metabolic pathways, resulting in limited differences compared to normal increased background signals from FI. To address this limitation, we developed a novel technique termed proximity-enhanced functional (PEFI) for accurate visualization of tumors. By using "two adjacent chemically labeled...