A5100404138- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Cerebral Venous Sinus Thrombosis
- Gastrointestinal motility and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Lymphocytic Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Ophthalmology and Eye Disorders
- Berberine and alkaloids research
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Autoimmune Neurological Disorders and Treatments
- Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Trigeminal Neuralgia and Treatments
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Extracellular vesicles in disease
- Vascular Tumors and Angiosarcomas
- RNA regulation and disease
Fudan University
2019-2025
Huashan Hospital
2019-2025
Shanghai Medical College of Fudan University
2022
South China University of Technology
2021
Guangzhou Medical University
2021
Guangzhou First People's Hospital
2021
Hebei Medical University
2021
Fourth Hospital of Hebei Medical University
2021
Tongji University
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS‐D) receiving berberine hydrochloride a randomized double‐blind placebo‐controlled trial. Overall, 196 patients with IBS‐D were recruited for this study; consequently, 132 receive daily 400 mg of hydrochloride, delivered twice or placebo 8 weeks followed by 4‐week washout period. After 2‐week run‐in period, diarrhea, abdominal pain, urgent need defecation frequency and any adverse events recorded...
Purpose: Current prognostic scoring systems for newly diagnosed primary central nervous system lymphoma (PCNSL), such as IELSG score and MSKCC score, are widely used but have limitations in clinical practice. This study aimed to develop a novel model based on real data compare it with existing systems. Patients Methods: A total of 288 patients PCNSL were recruited. randomly allocated the development validation cohorts. The least absolute shrinkage selection operator (LASSO) regression...
This study examined the prevalence, risk factors, and prognosis of epilepsy in patients with primary central nervous system lymphoma (PCNSL) explored necessity prophylactic antiepileptic treatment this population. In retrospective, observational, single-center study, we analyzed clinical data from PCNSL who were diagnosed at our institution between January 2018 April 2023. The cohort comprised 214 (with a median age 62 years), which 128 (47.6%) male. Epilepsy was observed 16.82% (36/214)...
Robust EV isolation from CSF by EVTRAP and downstream in-depth phosphoproteome analysis in PCNSL were performed, demonstrating its potential applications.
The pathological diagnosis of primary central nervous system lymphoma (PCNSL) by stereotactic brain biopsy and craniotomy is not often applicable due to the high cost associated complications. In recent years, some biomarkers in cerebrospinal fluid (CSF), including interleukin 10 (IL-10), microRNAs, CXC chemokine ligand 13 (CXCL13), have been reported be with PCNSL. However, this conclusion was controversial. Therefore, study test whether Th17 cell-related cytokines could used distinguish...
High-dose methotrexate (HD-MTX)-based chemotherapy regimen is the first-line treatment of primary central nervous system lymphoma (PCNSL). At present, doses MTX in range 3.5-8 g/m2 are frequently used. However, optimal dose for PCNSL remains controversial. The purpose this real-world study was to compare efficacy and toxicity HD-MTX patients with untreated PCNSL.Immunocompetent adults newly diagnosed between January 2015 December 2018 were investigated followed up June 2019. All patients'...
Background Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL. Materials and methods Patients diagnosed PCNSL who were treated at our institution between December 2018 2019 retrospectively screened. Patient variables including age, sex, Karnofsky performance status, diagnostic methods, location lesions, lactate dehydrogenase, cerebrospinal fluids (CSF),...
Introduction: Primary central nervous system lymphoma (PCNSL) is a rare subtype of aggressive extranodal non-Hodgkin lymphoma. Currently, there no standard care for the treatment refractory or relapsed PCNSL (r/r PCNSL). We conducted prospective single-arm phase II study to evaluate zanubrutinib plus cytarabine r/r PCNSL. Methods: Using Simon’s two-stage design, we analyzed 34 patients who received high-dose (3.0 g/m2 once daily) 2 days and (160 mg twice 21 each cycle up 6 cycles. The was...
Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy our institution. Methods performed retrospective study 279 patients with HPSCC who underwent radiotherapy or without chemotherapy followed by neck dissection between November 1965 and December 2008. Patients were divided into four groups according quartiles...
Background Disruption of the blood–brain barrier (BBB) is an important pathophysiological process anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. A recent multi-center study showed that soluble (s) CD146 a potential biomarker for monitoring early BBB damage and central nervous system inflammation, but little known about sCD146 in anti-NMDAR Method Twenty-three encephalitis patients seventeen controls with non-inflammatory neurological diseases were recruited. inflammatory...
Objective: Several population pharmacokinetic (popPK) models have been developed to determine the sources of methotrexate (MTX) PK variability. It remains unknown if these published are precise enough for use or a new model needs be built. The aims this study were 1) assess predictability and 2) analyze potential risk factors delayed MTX elimination. Methods: A total 1458 plasma concentrations, including 377 courses (1-17 per patient), collected from 77 patients who receiving high-dose...
Background Primary central nervous system lymphoma (PCNSL) is an uncommon variant of non-Hodgkin (NHL) with high aggressiveness and poor prognosis. Although complete remission (CR) could be achieved therapy, some patients remain refractory or recurrently a worse response to salvage treatment No consensus on rescue therapy has been established currently. This study aimed evaluate the efficacy radiotherapy chemotherapy in first-time relapsed progressed PCNSL (R/R PCNSL) analysis prognostic...
Purpose: The aim of this study was to identify the risk factors for central nervous system (CNS) involvement in systemic diffuse large B-cell lymphoma (DLBCL) patients and explore prognostic DLBCL with CNS (relapse or progression). Patients methods: This a retrospective cohort our hospital. Data were collected from all diagnosed institutes January 2013 June 2018. Clinical information medical records. Results: participants included 138 DLBCL. Among them, 38 as lymphoma, including 15 exhibited...
The prognosis of relapsed/refractory (R/R) primary central nervous system lymphoma (PCNSL) is dismal, and there are limited treatment options for these patients. This was a prospective single-arm phase II study combined pemetrexed lenalidomide salvage R/R PCNSL. Patients with PCNSL (n = 38) who had undergone two or more different therapeutic regimens experienced disease progression recurrence were enrolled. endpoint overall response rate (ORR). Secondary endpoints progression-free survival...
Primary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin's B-cell which normally treated by high-dose methotrexate (HD-MTX)-based chemotherapy. However, such treatment cannot always guarantee good prognosis (GP) outcome while suffering several side effects. Thus, biomarkers or biomarker-based models that can predict PCNSL patient would be beneficial.
Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin's that affects brain parenchyma, eyes, cerebrospinal fluid, and spinal cord. Diagnosing PCNSL can be challenging because imaging studies often show similar patterns as other tumors, stereotactic lesion biopsy conformation invasive not always possible. This study aimed to validate previous proteomic profiling (PMID: 32610669) fluid (CSF) develop CSF-based panel for accurate diagnosis differentiation.
Background: Due to the poor prognosis and rising occurrence, there is a crucial need improve diagnosis of Primary Central Nervous System Lymphoma (PCNSL), which rare type non-Hodgkin's lymphoma. This study utilized targeted metabolomics cerebrospinal fluid (CSF) identify biomarker panels for improved or differential primary central nervous system lymphoma (PCNSL). Methods: In this study, cohort 68 individuals, including patients with non-malignant disease controls, other brain tumors, was...
Our study was conducted to explore the relationship between cerebral venous sinus thrombosis (CVST) and intracranial arteritis during time of pregnancy as well puerperium. The current retrospective case involved a total 153 patients with pregnancy-related CVST. CVST diagnosed mainly based on clinical manifestations imaging results. Detailed information demographics, risk factors (excluding arteritis), outcomes systematically recorded. average age 28.67±3.54 years old. Among these patients,...
An effective salvage regimen for the reinduction of remission is lacking refractory or relapsed primary central nervous system lymphoma (r/r PCNSL). This study aimed to evaluate efficacy and safety cytarabine plus temozolomide in treating r/r PCNSL explore associated prognostic factors.A single-center retrospective cohort was conducted assess (AT) patients. KIR HLA genotyping performed on peripheral blood samples.Thirty patients receiving an AT (cytarabine 3 g/m2 2 days combined with 150...
Background: The significance of asymmetric enhancement on cavernous sinus MRIs in the differential diagnosis ischemic and inflammatory oculomotor cranial nerve (OCN) palsies remains controversial. This study explored MRI findings for idiopathic inflammation (inflammation group), microvascular OCN palsy (ischemic ocular myasthenia gravis (OMG group) patients. Methods: A total 66, 117, 60 patients were included inflammation, ischemic, OMG groups, respectively. Cavernous retrospectively...
Abstract Purpose The aim of this study was to identify the risk factors for central nervous system (CNS) involvement in systemic diffuse large B-cell lymphoma (DLBCL) patients and explore prognostic DLBCL with CNS (relapse or progression). Method This a retrospective cohort our hospital. Data were collected from all diagnosed institutes January, 2013 June, 2018. Clinical information medical records. Result participants included 138 DLBCL. Among them, 38 as lymphoma, including 15 exhibited...
Abstract Purpose The aim of this study was to identify the risk factors for central nervous system (CNS) involvement in systemic diffuse large B-cell lymphoma (DLBCL) patients and explore prognostic DLBCL with CNS (relapse or progression). Method This a retrospective cohort our hospital. Data were collected from all diagnosed institutes January, 2013 June, 2018. Clinical information medical records. Result participants included 138 DLBCL. Among them, 38 as lymphoma, including 15 exhibited...
Abstract Purpose An effective salvage regimen for re-induction of remission is lacking refractory or recurrent primary central nervous system lymphoma (r/r PCNSL). This study aimed to evaluate the efficacy and safety high dose cytarabine plus temozolomide in treating r/r PCNSL explore prognostic factors Methods A single-center retrospective cohort was conducted access (AT) patients. KIR HLA genotyping were performed from peripheral blood sample each patient. Results Thirty patients receiving...