A5074481938- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Marine and coastal ecosystems
- Plant nutrient uptake and metabolism
- Long-Term Effects of COVID-19
- Microbial Community Ecology and Physiology
- Plant Reproductive Biology
- Bacillus and Francisella bacterial research
- Cervical Cancer and HPV Research
- SARS-CoV-2 detection and testing
- Algal biology and biofuel production
- Rice Cultivation and Yield Improvement
- Plant Gene Expression Analysis
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- COVID-19 Impact on Reproduction
- Liver Diseases and Immunity
- GABA and Rice Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Tea Polyphenols and Effects
Ruijin Hospital
2018-2024
Shanghai Jiao Tong University
2020-2024
Xiamen University
2016-2024
State Key Laboratory of Marine Environmental Science
2016-2024
Guangzhou First People's Hospital
2020-2024
Guangzhou Medical University
2020-2024
Xihua University
2024
Nanjing Foreign Language School
2024
South China University of Technology
2020-2024
China National Rice Research Institute
2019-2022
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement clinical...
Abstract Currently, there are no approved specific antiviral agents for 2019 novel coronavirus disease (COVID-19). In this study, ten severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement...
Summary Lesion‐mimic mutants (LMMs) provide a valuable tool to reveal the molecular mechanisms determining programmed cell death (PCD) in plants. Despite intensive research, behind PCD and formation of lesions various LMMs still remain be elucidated. Here, we identified rice ( Oryza sativa ) LMM, early lesion leaf 1 ell1 ), cloned causal gene by map‐based cloning, verified this complementation. ELL1 encodes cytochrome P450 monooxygenase, protein was located endoplasmic reticulum. The mutant...
Abstract The coronavirus disease 2019 (COVID‐19) is a pandemic caused by severe acute respiratory syndrome 2 (SARS‐CoV‐2). However, little known about the durability of antibody response during COVID‐19 convalescent phase. We investigated prevalence anti‐SARS‐CoV‐2 specific antibodies including immunoglobulin G (IgG) and M (IgM) dynamic changes in levels patients. A total 159 blood samples were collected from 52 recovered patients up to six months after symptom onset for longitudinal...
Abstract The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the generation variants that may diminish host immune responses to vaccine formulations. Here we show a registered observational clinical trial (NCT04795414), assess safety and immunogenicity inactivated SARS-CoV-2 BBIBP-CorV cohort 1006 recipients. No serious adverse events are observed during term study. Detectable virus-specific antibody is measured determined be neutralizing...
Objective Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to production hepatitis surface antigen (HBsAg) and hepatocarcinogenesis. In this study, we aimed explore whether transcriptionally active HBV integration events spread throughout liver tissue in different phases chronic infection, especially patients with HBsAg loss. Design We constructed high-resolution spatial transcriptomes biopsies containing 13 059 spots from 18 infection analyse...
Background: The sudden outbreak of COVID-19 has caused mental stress on healthcare workers (HCW). This study aimed to assess their psychological health status at the peak and identify some coping strategies. Methods: A cross-sectional survey was conducted during COVID-19. completed by 908/924 HCW (response rate 98.27%) in government-designated hospitals Guangdong, China. quality life (QoL) scale, Zung Self-Rating Anxiety Scale (SAS), Depression (SDS) were used evaluate status. Logistic...
Since the first report of coronavirus disease (COVID-19) in late December 2019, pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has now widely spread to more than 187 countries and regions. However, it is unclear whether there been cryptic transmission before these early officially confirmed cases, we therefore retrospectively screened for SARS-CoV-2 RNA 1271 nasopharyngeal swab samples, as well prevalence IgM, IgG, total antibodies against 357 matched serum samples...
The presence of antiphospholipid antibodies was shown to be associated with thrombosis in coronavirus disease 2019 (COVID-19) patients. Recently, according reports from several studies, the vaccine-induced immune thrombotic thrombocytopenia is mediated by anti-platelet factor 4 (PF4)-polyanion complex adenovirus-vectored COVID-19 vaccine recipients. It impendent explore whether inactivated widely used China influences prothrombotic autoantibody production and induces thrombosis. In this...
<p id="p00005">High school is the key period of psychological development, and it also frequent a variety problems. The mental health problems senior high students not only come from adolescents themselves, but should attract extensive attention families, schools society. In order to improve ensure effective development follow-up work, necessary understand detection rate in China, so as master basic situation students. Although many previous studies have involved students, there no...
Summary The palea and lemma (hull) are grass‐specific organs, determine grain size quality. In the study, AH 2 encodes a MYB domain protein, functions in development of hull grain. Mutation produces smaller grains alters quality including decreased amylose content gel consistency, increased protein content. Meantime, part lost outer silicified cells, induces transformation rough epidermis to inner smooth body was reduced ah2 mutant. We confirmed function by complementation, CRISPR ‐Cas9,...
Rice (Oryza sativa) spikelets are a unique inflorescence structure and their development directly determines grain size yield. Although many genes related to spikelet have been reported, the molecular mechanisms underlying this process not fully elucidated. In study, we identified new recessive rice mutant, lacking rudimentary glume 1 (lrg1). The lrg1 only formed one glume, which, along with sterile lemmas, was homeotically transformed into lemma-like organs acquired lemma identity....
Abstract Algicidal microbes could effectively remove the harmful algae from waters. In this study, we were concerned with ecological influence of an algicide extracted Streptomyces alboflavus RPS, which completely lyse Phaeocystis globosa cells within two days. microcosms, 4 μg/mL microbial efficiently P. without suppressing other aquatic organisms. Bioluminescent assays confirmed that toxicity at concentration was negligible. Interestingly, exudates also significantly reduced after being...
Rice (Oryza sativa) spikelets have a unique inflorescence structure, and the mechanisms regulating their development are not yet fully understood. Moreover, approaches to manipulate spikelet potential increase grain yield. In this study, we identified characterized recessive mutant, namely more floret1 (mof1). The mof1 mutant has delayed transition from floral meristem, inducing formation of extra lemma-like palea-like organs. addition, main body palea was reduced, sterile lemma enlarged...
Abstract The Omicron Variant of Concern (B.1.1.529) has spread internationally and is raising serious concerns about reduced vaccine efficacy the increased risk reinfection. We assessed serum neutralizing activity using a pseudovirus-based neutralization assay in 292 healthcare workers who had received homologous booster dose BBIBP-CorV vaccine, 8 to 9 months after completing priming two-dose vaccination schedule, investigate whether newly identified variant can escape antibody induced by...
Abstract Depression is one of the most common psychiatric diseases worldwide. With increase in number depressive episodes, cognitive dysfunction may be accelerated. Although significant findings related to pathogenesis depression have been reported, precise molecular mechanisms depression-related disorders not yet fully clarified. In this study, we collected serum copper levels and evaluated functions patients with major disorder (MDD) healthy controls. Furthermore, adopted a chronic...
From 21 January 2020 to 9 February 2020, three family clusters involving 31 patients with coronavirus disease 2019 were identified in Wenzhou, China. The epidemiological and clinical characteristics of the cluster analysed compared those 43 contemporaneous sporadic cases. index cases transmitted infection 28 members 2-10 days before illness onset. Overall, 41 came back from Wuhan (65.12 vs. 9.68%, P< 0.001). In terms characters symptoms, no significant differences observed between However,...