A5100441993- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Inflammation biomarkers and pathways
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Otitis Media and Relapsing Polychondritis
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Amyotrophic Lateral Sclerosis Research
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood disorders and treatments
- Family and Disability Support Research
- Systemic Sclerosis and Related Diseases
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Hematological disorders and diagnostics
- Inflammatory Myopathies and Dermatomyositis
Liaocheng People's Hospital
2025
Chongqing Cancer Hospital
2023-2025
Chongqing University
2023-2025
Jiangsu University
2025
First People's Hospital of Kunshan
2025
Ruijin Hospital
2019-2024
Shanghai Jiao Tong University
2012-2024
Shandong First Medical University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangxi Provincial People's Hospital
2024
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
Janus hybrids with amphiphilic structures were used for the sensitive detection of small metabolites.
Previous studies have revealed that several micro-organisms, especially DNA viruses, been associated with adult-onset Still's disease (AOSD). However, there are no on the relationship between presence of viral infections in AOSD patients occurrence and reactivation. In present study, we aimed to investigate antibodies against virus, virus load nucleic acid sensors patients. Anti-viral were measured by enzyme-linked immunosorbent assay (ELISA) plasma samples from 100 70 healthy controls...
Aerobic exercise improves lung inflammation in acute injury (ALI) but its mechanism remains unknown. Neutrophil extracellular traps (NETs) play an important role LPS-induced ALI, and a positive correlation exists between NETs formation proinflammatory macrophage polarization. This study investigated whether aerobic reduces the pro-inflammatory polarization of alveolar macrophages (AMs) by inhibiting excessive release NETs, then alleviating inflammatory response ALI. Methods: C57BL/6 male...
The presence of antiphospholipid antibodies was shown to be associated with thrombosis in coronavirus disease 2019 (COVID-19) patients. Recently, according reports from several studies, the vaccine-induced immune thrombotic thrombocytopenia is mediated by anti-platelet factor 4 (PF4)-polyanion complex adenovirus-vectored COVID-19 vaccine recipients. It impendent explore whether inactivated widely used China influences prothrombotic autoantibody production and induces thrombosis. In this...
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
Abstract Objective To investigate the use of antimicrobials during perioperative period minimally invasive coronary artery bypass grafting (MICS CABG) and traditional open-heart grafting. We aimed to determine whether duration antibiotic infection rate is significantly different between surgical methods. Methods A total 471 cases (CABG) were collected from January 2019 December 2022. Patients divided into group (229 cases) a conventional (242 according type surgery. compared differences in...
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by cytokine storm. However, diagnostic test for AOSD in clinical use yet to be validated. The aim of our study was identify noninvasive biomarkers with high specificity and sensitivity diagnosis AOSD. MicroRNA (miRNA) profiles PBMC from new-onset patients without any treatment healthy controls (HCs) were analyzed miRNA deep sequencing. Plasma samples 100 60 HCs used validated the expression levels qRT-PCR....
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Anti-β2GP1 (β2-glycoprotein 1) antibodies are the primary pathogenic antibody to promote thrombosis in antiphospholipid syndrome (APS), yet underlying mechanism remains obscure. We aimed explore intracellular pathway that mediated platelet activation. Platelets were isolated from patients with APS and subjected RNA sequencing. Platelet aggregation, release of granules, spreading, clot retraction detected evaluate purified anti-β2GP1 total IgG healthy donors stimulate platelets with/without...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
Lactic acid (LA) is a sensitive indicator of exercise intensity and duration. A single bout prolonged intensive can cause transient immunosuppression through the interaction cellular, humoral, hormone factors. Exercise-induced influences on neutrophil extracellular traps (NETs) release have been reported, but underlying mechanism unknown. This study investigated NETs release, cell-free DNA (cf-DNA), LA concentration in mice after 60 145 min intensive, graded treadmill running. The cf-DNA...
Adult-onset Still's disease (AOSD) is an autoinflammatory with multisystem involvement. Early identification of patients severe complications and those refractory to glucocorticoid crucial improve therapeutic strategy. Exaggerated neutrophil activation enhanced formation extracellular traps (NETs) in AOSD were found be closely associated etiopathogenesis. In this study, we aim investigate, our knowledge for the first clinical value circulating NETs by machine learning distinguish organ...
Background KRAS and NRAS gene mutations are frequently observed in childhood leukemia. The objective of this study was to determine the frequency RAS association between other genetic aberrations Arab Asian children with acute lymphoblastic leukemia (ALL) or myeloid (AML). Methods Diagnostic samples 485 patients (<18 years) from Iraq Jordan were obtained, using Flinders Technology Associates filter papers. Polymerase chain reaction direct sequencing performed Japan. Results detected 86/318...
Objective Adult‐onset Still’s disease (AOSD) is a severe autoinflammatory disease. Neutrophil activation with enhanced neutrophil extracellular trap (NET) formation involved in the pathogenesis of AOSD. Functional leukocyte immunoglobulin‐like receptor A3 (LIR‐A3; gene name LILRA3 ) has been reported to be associated many autoimmune diseases. We aimed investigate association susceptibility and Methods The deletion polymorphism its tagging single‐nucleotide rs103294 were genotyped 164...
Adult-onset Still's disease (AOSD) is a systemic, multigenic autoinflammatory and the diagnosis of AOSD must rule out neoplasms, infections, other autoimmune diseases. Development rapid, efficient but noninvasive method urgently needed for improving therapy. In this study, we first performed urinary proteomic study using isobaric tags relative absolute quantification (iTRAQ) labeling combined with LC-MS/MS analysis in patients healthy control (HC) subjects. The proteins were enriched...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is an amplifier of inflammatory signals. Recently, a soluble form TREM-1 (sTREM-1) was described. This study aimed to investigate the role serum sTREM-1 in patients with adult-onset Still's disease (AOSD).Serum levels were detected 108 AOSD patients, 88 RA and 112 healthy controls (HC). The correlations activity, clinical characteristics laboratory parameters analysed by Spearman correlation test. Risk factors for chronic course...