A5080867792- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Inflammation biomarkers and pathways
- Kawasaki Disease and Coronary Complications
- Systemic Sclerosis and Related Diseases
- Pressure Ulcer Prevention and Management
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Otitis Media and Relapsing Polychondritis
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Diagnosis and Treatment of Venous Diseases
- Rheumatoid Arthritis Research and Therapies
- Family and Disability Support Research
- Adrenal and Paraganglionic Tumors
- Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
Saitama Medical University
2019
Shanghai Clinical Research Center
2014
Adrenal Cushing’s syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders. We performed whole-exome sequencing 49 blood-tumor pairs RNA 44 cortisol-producing adenomas (ACAs), adrenocorticotropic hormone–independent macronodular hyperplasias (AIMAHs), oncocytomas (ADOs). identified a hotspot in the PRKACA gene with L205R mutation 69.2% (27 out 39) ACAs validated 65.5% total 87 ACAs. Our data revealed that...
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
Diabetes leads to amputation in approximately 15% 20% of patients and is associated with high morbidity mortality. Thus, improving the quality wound healing this condition essential. acute/chronic inflammation affecting all organs especially foot, while, inhibition microRNA-155 (miR-155) has been reported improve or reduce inflammatory situation. However, role miR-155 promoting diabetic not clear. To further study potential benefit inhibition, a male Sprague-Dawley rats was conducted...
Previous studies have revealed that several micro-organisms, especially DNA viruses, been associated with adult-onset Still's disease (AOSD). However, there are no on the relationship between presence of viral infections in AOSD patients occurrence and reactivation. In present study, we aimed to investigate antibodies against virus, virus load nucleic acid sensors patients. Anti-viral were measured by enzyme-linked immunosorbent assay (ELISA) plasma samples from 100 70 healthy controls...
Uric acid metabolism disorder triggers metabolic diseases, especially gout. However, increasing uric excretion remains a challenge. Here, an accelerative pathway via oral intestine-explosive hydrogel microsphere merely containing uricase and dopamine is reported. After administration, exposed immobilized on intestinal mucosa along with in situ polymerization cascade reaction triggered by the specific environment. By this means, trace amount of required to up-regulate transporter proteins...
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
<title>Abstract</title> Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” cell blueprint at single-cell resolution, wherein we observed substantial increase subsets across nearly all developmental stages. Notably, interferon...
Adult-onset Still's disease (AOSD) is an autoinflammatory disorder characterized by reactive neutrophilia and dysregulated cytokine release. Mature neutrophils exhibit increased alkaline phosphatase enzyme activity within cytoplasmic granules, particularly in response to inflammation or acute infection. However, whether neutrophil (NAP) elevated active AOSD, a hyperinflammatory state, remains unclear. We enrolled 114 patients diagnosed with 47 diffuse large B-cell lymphoma (DLBCL), 25...
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Anti-β2GP1 (β2-glycoprotein 1) antibodies are the primary pathogenic antibody to promote thrombosis in antiphospholipid syndrome (APS), yet underlying mechanism remains obscure. We aimed explore intracellular pathway that mediated platelet activation. Platelets were isolated from patients with APS and subjected RNA sequencing. Platelet aggregation, release of granules, spreading, clot retraction detected evaluate purified anti-β2GP1 total IgG healthy donors stimulate platelets with/without...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates the regulation of pathogenesis adult-onset Still’s disease (AOSD) not investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, explored anti-inflammatory effects on peripheral blood mononuclear cells (PBMCs) from patients AOSD. Blood samples were collected 62 AOSD 50 healthy control subjects (HC). The determined using...
The burden of obesity and associated cardiometabolic diseases have been considered as an important risk factor for lupus patients. Therefore, the links between autoimmunity were questioned, involvement in rise autoimmune conditions was strongly suggested. Hydroxychloroquine is known one most fascinating synthetic antimalarial drugs, presently among commonly employed medicines clinical treatment rheumatic diseases. has suggested to beneficial effects on lipids insulin sensitivity, which may...
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by cytokine storm. Efficient early diagnosis AOSD-associated MAS requires sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD activity served as biomarker for AOSD-MAS. PTX3 levels were significantly increased in patients compared to other autoimmune diseases healthy controls. Plasma showed...
Importance Anti–double-stranded DNA (dsDNA) antibody has been reported to have a close relationship with systemic lupus erythematosus (SLE) flares and participates in the pathogenesis of nephritis (LN) as well causing damage other organs. However, whether early use mycophenolate mofetil (MMF) could prevent SLE is not clear. Objective To assess efficacy safety MMF plus prednisone hydroxychloroquine sulfate compared alone patients SLE. Design, Setting, Participants This investigator-initiated,...