A5030899889- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Blood disorders and treatments
- Otitis Media and Relapsing Polychondritis
- Inflammation biomarkers and pathways
- Viral Infections and Immunology Research
- Family and Disability Support Research
- Retinopathy of Prematurity Studies
- Acute Myeloid Leukemia Research
- Sepsis Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Identity, Memory, and Therapy
Ruijin Hospital
2017-2025
Shanghai Jiao Tong University
2011-2025
Anhui University of Traditional Chinese Medicine
2025
Binzhou University
2025
Binzhou Medical University
2025
Beijing Chao-Yang Hospital
2021-2024
Capital Medical University
2012-2024
Beijing Tongren Hospital
2022-2024
Chinese PLA General Hospital
2024
XinHua Hospital
2024
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the small blood vessels of patients who succumb to disease. Antiphospholipid syndrome is an acquired potentially life-threatening thrombophilia which develop pathogenic autoantibodies targeting phospholipids phospholipid-binding proteins (aPL antibodies). Case series have recently detected aPL antibodies COVID-19. Here, we measured eight types...
Objective While endothelial dysfunction has been implicated in the widespread thromboinflammatory complications of COVID‐19, upstream mediators endotheliopathy remain, for most part, unknown. This study was undertaken to identify circulating factors contributing cell activation and COVID‐19. Methods Human cells were cultured presence serum or plasma from 244 patients hospitalized with COVID‐19 100 non–COVID‐19–related sepsis. Cell adhesion molecules (E‐selectin, vascular molecule 1,...
ABSTRACT Objective Currently, chimeric antigen receptor T‐cell (CART) therapy represents a highly effective approach for relapsed/refractory B‐cell lymphomas. However, it also carries treatment‐related risks. Limited data are available on the risks associated with CART in patients gastrointestinal involvement Therefore, we conducted retrospective cohort study to address this gap knowledge. Methods During period from May 2019 August 2022, total of 26 recurrent/refractory lymphoma involving...
Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels blood neutrophils associate with worsening oxygenation in COVID-19, is unknown whether drivers the thrombo-inflammatory storm or simple bystanders. To better understand potential role we measured neutrophil activation marker S100A8/A9 (calprotectin) hospitalized patients and determined its relationship to severity illness status. Patients...
Background: The present study investigated the prevalence of refractive error, visual impairment, and eye diseases in school-aged children western China.Methods: survey was done a representative county (Yongchuan District, Chongqing Municipality) China. Cluster random sampling used to select aged 6 15 years. We conducted door-to-door surveys examinations including optometry, stereoscopic vision test, position movement, slit lamp examination anterior segment, retinoscopy, fundus after...
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
This study investigated the distribution pattern of refractive status and prevalence errors in school-age children Western China to determine possible environmental factors.A random sampling strategy geographically defined clusters was used identify aged 6-15 years Yongchuan, a socio-economically representative area China. We carried out door-to-door survey actual eye examinations, including visual acuity measurements, stereopsis examination, anterior segment eyeball movements, fundus...
ABSTRACT Patients with coronavirus disease 19 ( COVID-19 ) are at high risk for thrombotic arterial and venous occlusions. At the same time, lung histopathology often reveals fibrin-based occlusion in small vessels of patients who succumb to disease. Antiphospholipid syndrome APS is an acquired potentially life-threatening thrombophilia which develop pathogenic autoantibodies aPL targeting phospholipids phospholipid-binding proteins. Case series have recently detected COVID-19. Here, we...
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
Previous studies have revealed that several micro-organisms, especially DNA viruses, been associated with adult-onset Still's disease (AOSD). However, there are no on the relationship between presence of viral infections in AOSD patients occurrence and reactivation. In present study, we aimed to investigate antibodies against virus, virus load nucleic acid sensors patients. Anti-viral were measured by enzyme-linked immunosorbent assay (ELISA) plasma samples from 100 70 healthy controls...
While endothelial dysfunction has been implicated in the widespread thrombo-inflammatory complications of coronavirus disease-19 ( COVID-19 ), upstream mediators endotheliopathy remain for most part cryptic. Our aim was to identify circulating factors contributing cell activation and COVID-19. Human cells were cultured presence serum or plasma from 244 patients hospitalized with 100 non-COVID sepsis. Cell adhesion molecules (E-selectin, VCAM-1, ICAM-1) quantified by in-cell ELISA. Serum...
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
<title>Abstract</title> Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” cell blueprint at single-cell resolution, wherein we observed substantial increase subsets across nearly all developmental stages. Notably, interferon...
The objective was to determine the mortality rate as well causes and predictors of in antiphospholipid antibody (aPL)-positive patients with/without APS classification. inclusion criteria for multicenter international ACTION registry are positive aPL according Revised Sapporo Classification Criteria tested within one year prior enrollment. Patients followed every 12 ± 3 months with clinical data blood collection. For this prospective analysis, firstly we analyzed death reported "deceased"....
Type 2 diabetes mellitus (T2DM), as a globally prevalent metabolic disorder, is continuously rising in prevalence and significantly increases the risk of developing coronary heart disease (CHD). Studies have shown that CHD higher T2DM patients compared to those without diabetes, making early identification prevention essential. Therefore, establishing an effective prediction model identify high-risk individuals for among crucial. This study aims develop validate with type mellitus,...
Abstract Introduction Given the chronic nature of knee osteoarthritis and its reliance on self-management, patients’ knowledge, attitudes, practice (KAP) significantly influence their ability to effectively manage osteoarthritis. This study aimed investigate KAP towards Methods cross-sectional survey was conducted among patients with osteoarthritis, using a self-designed questionnaire. Results A total 764 (96.47%) valid questionnaires enrolled, including 451 (59.03%) females, mean age 48.28...