A5061622549- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Inflammation biomarkers and pathways
- Diabetes and associated disorders
- Kawasaki Disease and Coronary Complications
- Spondyloarthritis Studies and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Otitis Media and Relapsing Polychondritis
- Atherosclerosis and Cardiovascular Diseases
- Gout, Hyperuricemia, Uric Acid
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Family and Disability Support Research
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Blood disorders and treatments
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Center for Rheumatology
2018
Renji Hospital
2006-2016
Sina (China)
2014
University of California, Los Angeles
2003-2007
Ten Chen Hospital
2004
Institute of Nuclear Physics
2003
Nanjing General Hospital of Nanjing Military Command
1998
Nanjing University
1998
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Objective. To describe the onset, clinical features, prognostic factors, and treatment of adult-onset Still’s disease (AOSD) in cases from China. Methods. Sixty-one Chinese patients with AOSD were analyzed retrospectively. Results. Common features fever (100.0%), rash (88.5%), arthritis (82.0%). The laboratory findings as follows: leukocytosis (83.6%), increased erythrocyte sedimentation rate elevated transaminase concentrations (23.0%), ferritin levels (79.6%), negative antinuclear antibody...
Background: Inflammatory bowel disease is a chronic and idiopathic gastrointestinal inflammation mediated by disregulated immune responses. Artemisinin (a chemical from traditional Chinese herbal medicine Artemisia annua L.) its derivatives have been proven to exhibit anti-inflammatory immunomodulatory effects in the treatment of systemic lupus erythematosus rheumatoid arthritis with low side-effects. This study aimed evaluate potential therapeutic value artesunate for inflammatory disease....
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
Abstract Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with urate gout. However, their influence on the progression elevated levels to gout unclear. This study aims explore systematically effects of genetic variants pathogenesis in approximately 5,000 Chinese individuals. Six genes ( PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A ) were determined be P FDR < 0.05) population for first time. ABCG2 novel gene, SLC17A4 ,...
Previous studies have revealed that several micro-organisms, especially DNA viruses, been associated with adult-onset Still's disease (AOSD). However, there are no on the relationship between presence of viral infections in AOSD patients occurrence and reactivation. In present study, we aimed to investigate antibodies against virus, virus load nucleic acid sensors patients. Anti-viral were measured by enzyme-linked immunosorbent assay (ELISA) plasma samples from 100 70 healthy controls...
The presence of antiphospholipid antibodies was shown to be associated with thrombosis in coronavirus disease 2019 (COVID-19) patients. Recently, according reports from several studies, the vaccine-induced immune thrombotic thrombocytopenia is mediated by anti-platelet factor 4 (PF4)-polyanion complex adenovirus-vectored COVID-19 vaccine recipients. It impendent explore whether inactivated widely used China influences prothrombotic autoantibody production and induces thrombosis. In this...
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
<title>Abstract</title> Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” cell blueprint at single-cell resolution, wherein we observed substantial increase subsets across nearly all developmental stages. Notably, interferon...
The objective of this study was to evaluate the feasibility using <sup>68</sup>Ga-labeled fibroblast activation protein inhibitor-04 (<sup>68</sup>Ga-FAPI-04) PET/CT imaging as a molecular tracer and noninvasive tool for assessing active renal tubulointerstitial fibrosis in patients with lupus nephritis (LN). <b>Methods:</b> included 29 LN who underwent <sup>68</sup>Ga-FAPI-04 scanning quantify uptake. Renal biopsies were performed within week scanning. levels biopsy samples assessed by...
Adult-onset Still's disease (AOSD) is an autoinflammatory disorder characterized by reactive neutrophilia and dysregulated cytokine release. Mature neutrophils exhibit increased alkaline phosphatase enzyme activity within cytoplasmic granules, particularly in response to inflammation or acute infection. However, whether neutrophil (NAP) elevated active AOSD, a hyperinflammatory state, remains unclear. We enrolled 114 patients diagnosed with 47 diffuse large B-cell lymphoma (DLBCL), 25...
Abstract The combined presence of anti-phospholipid Ab (aPL) and thrombosis is recognized as the antiphospholipid syndrome (APS). aPL represent a heterogeneous group that recognize various phospholipids (PL), PL-binding plasma proteins, and/or PL-protein complexes. Recently, we found antithrombin in some APS patients these anti-thrombin could inhibit thrombin inactivation by antithrombin. Considering homologous to plasmin, which dissolves fibrin, hypothesize may have react with anti-plasmin...
To test the effects of a novel monoclonal antibody (mAb) against human osteopontin (OPN) in prevention and treatment collagen-induced arthritis (CIA) to elucidate underlying mechanisms these effects.DBA/1J mice immunized with type II collagen induce CIA were monitored assess anti-OPN mAb on clinical severity disease, pathologic changes joints examined histologically. The survival activated T cells from arthritic synovial fluid patients rheumatoid (RA) determined by TUNEL assay or annexin V...
Abstract Introduction Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT largely unknown. Although several studies have reported the association of antiphospholipid antibodies (aPL) GMT, relation between and aPL remains controversial. Previous demonstrated that some could bind to hemostatic fibrinolytic proteases share homologous enzymatic domains. Of protease-reactive aPL, can inhibit anticoagulant activity...