A5100714279- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Bowel Disease
- Diabetes and associated disorders
- Traditional Chinese Medicine Studies
- Systemic Lupus Erythematosus Research
- Toxin Mechanisms and Immunotoxins
- Atherosclerosis and Cardiovascular Diseases
- Lignin and Wood Chemistry
- Catalysis for Biomass Conversion
- Protein Tyrosine Phosphatases
- Mycobacterium research and diagnosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Osteomyelitis and Bone Disorders Research
- Global Health and Surgery
- Liver Diseases and Immunity
- Global Health Workforce Issues
- Ocular Diseases and Behçet’s Syndrome
- Abdominal vascular conditions and treatments
Yueyang Hospital
2012-2025
Shanghai University of Traditional Chinese Medicine
2012-2025
Linyi People's Hospital
2024
North China Electric Power University
2022-2024
Jilin University
2022-2023
First Hospital of Jilin University
2023
Wannan Medical College
2020
First Affiliated Hospital of Wannan Medical College
2020
University of Southampton
2015
Shanghai University
2014
Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential mechanism action.
Previous studies have found an association between ankylosing spondylitis (AS) and chronic obstructive pulmonary disease (COPD); however, no research has investigated this relationship using Mendelian randomization (MR). This study employed a bidirectional two-sample MR approach to assess the causal connection AS COPD. The analysis utilized publicly available statistics on COPD from Genome-wide Association Study (GWAS). primary method was Inverse-Variance Weighting (IVW), supplemented by...
The objective of this study was to evaluate the feasibility using <sup>68</sup>Ga-labeled fibroblast activation protein inhibitor-04 (<sup>68</sup>Ga-FAPI-04) PET/CT imaging as a molecular tracer and noninvasive tool for assessing active renal tubulointerstitial fibrosis in patients with lupus nephritis (LN). <b>Methods:</b> included 29 LN who underwent <sup>68</sup>Ga-FAPI-04 scanning quantify uptake. Renal biopsies were performed within week scanning. levels biopsy samples assessed by...
Gout is a chronic disease caused by the deposition of sodium urate crystals, which prone to multiple comorbidities, especially cardiovascular and kidney diseases. Patients with gout have higher all-cause cause-specific mortality. However, it unclear whether affects survival in ICU patients. Data patient cohort were obtained from MIMIC IV database. The difference between two groups was compared Log-rank method. Cox regression used estimate hazard ratio. Possible influencing factors adjusted...
Background Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) share common traits of chronic recurrent inflammation affecting both the intestines joints. Epidemiological studies have revealed that incidence AS has jumped from 0.3% to 3% among patients with IBD. However, these findings do not definitively establish a causal relationship whereby IBD directly leads development AS. Moreover, whether activity will an impact on this process remains pending question. Methods...
The close relationship between ankylosing spondylitis (AS) and inflammatory bowel diseases (IBD) has been supported by many aspects, including but not limited to clinical manifestations, epidemiology pathogenesis. Some evidence suggests that immune cells actively participated in the pathogenesis of both diseases. However, information on which are primarily involved this process how these mobilize, migrate interact is still limited.Datasets were downloaded from Gene Expression Omnibus (GEO)...
Previously synthesized N-butyrylated hyaluronic acid (BHA) provides anti-inflammatory effects in rat models of acute gouty arthritis and hyperuricemia. However, the mechanism action remains to be elucidated. Herein, antioxidative activities BHA targeted signaling pathways were explored with LPS-induced RAW264.7 an adjuvant-induced inflammation a model. Results indicated that inhibited generation pro-inflammatory cytokines TNFα, IL-1β IL-6, reduced ROS production down-regulated JAK1-STAT1/3...
Rapid remission of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome in response to the Janus kinase inhibitor tofacitinib: A case report
Fibrinogen to albumin ratio (FAR) is a newly investigated indicator for inflammation. The study aimed explore the potential ability of FAR in assessing severity inflammation spondyloarthritis.The clinical data 196 spondyloarthritis (SpA) patients, 66 osteoarthritis (OA) and 81 healthy controls (HC) were collected this retrospective study. SpA group included 69 psoriatic arthritis 47 reactive patients 80 ankylosing spondylitis patients. Chi-square test Mann-Whitney U test, Spearman's...
Objective . To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS. Methods 40 low-activity-level pSS without visceral involvement participated this study were randomized to receive either or placebo HCQ. Patients investigators blinded treatment allocation. The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary lacrimal gland function, some laboratory variables. Safety-related data also...
Reactive arthritis (ReA) is defined as inflammatory secondary to an extra-articular infection with a key genetic background, HLA-B27. However, date, the diagnosis and classification remain incomplete. The study focused on similarities differences in clinical manifestation, imaging features, laboratory inspection between HLA-B27 negative patients positive order provide reference for future development of diagnostic criteria. Twenty-five ReA (19 6 patients) were included this retrospective...
Objective: To investigate the efficacy of Integrative medicine (IM), compare with Western (WM), in treatment rheumatoid arthritis (RA) a cohort study. Methods: This is study recruitment RA patients from 10 hospitals China. The primary outcome was change disease activity score 28 (DAS28) during 4 follow-up visits. Generalized estimating equation (GEE) models that controlled for variables were used to time trend and assess group differences secondary outcomes after propensity matching (PSM)....
Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides opportunity to comprehensively unravel the contributory role monocytes/macrophages in intricate pathogenesis pSS.
Objective . To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods A total 2452 RA at Hospitals Shanghai between January 2009 and February 2011 were analyzed. Their demographic clinical characteristics compared those without infection, determined by logistic regression analysis. Results Multivariate analysis indicated gender (<mml:math...
Abstract Tumor suppressor genes (TSGs) play critical roles in preventing tumorigenesis and they are frequently inactivated tumours. Recently developed high-density microarrays can detect subchromosomal deletions, recurrence of which usually indicates the location TSGs within deleted region. We analyzed testicular germ cell tumour (TGCT) clinical samples using SNP arrays found a frequent small deletion on region 6q25.3 containing only one known gene, ZDHHC14. While its cellular function is...