A5101956441- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Mast cells and histamine
- Lymphoma Diagnosis and Treatment
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Ichthyology and Marine Biology
- Liver Disease Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Sphingolipid Metabolism and Signaling
- Proteoglycans and glycosaminoglycans research
- Hypertrophic osteoarthropathy and related conditions
- Genetic Associations and Epidemiology
- Urticaria and Related Conditions
- Wnt/β-catenin signaling in development and cancer
- Systemic Sclerosis and Related Diseases
- Speech and dialogue systems
Shandong First Medical University
2021-2024
Guangzhou Medical University
2023
Bristol-Myers Squibb (United States)
2021
Changhai Hospital
2010-2015
Second Military Medical University
2010-2015
Shanghai Changzheng Hospital
2014
Bristol-Myers Squibb (Switzerland)
2007-2012
We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of yeast Saccharomyces cerevisiae. Suppression other pathway-activating events was examined. In wild-type cells, expression either or gps2 led to enhanced recovery from cell cycle arrest induced by pheromone. Sequence analysis indicated contains only carboxy-terminal half gps1 coding sequence. The predicted gene product has striking similarity...
Objectives The hallmark of systemic sclerosis (SSc) is the accumulation extracellular matrix proteins by pathologically activated fibroblasts. This study analysed antifibrotic effects selective c-Jun N-terminal kinase (JNK) inhibitor, CC-930, which recently entered first clinical trials as a novel approach. Methods Phosphorylated was detected western blot and immunohistochemistry. model bleomycin-induced dermal fibrosis tight skin 1 (TSK1) mouse were used to investigate CC-930 on prevention...
The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. functions of β-catenin several other components this have investigated However, the potential role R-spondin proteins (RSPOs), enhancers signaling, not described. A specific interventional strategy targeting for fibrosis remains to be defined. We developed monoclonal antibodies against members RSPO family (RSPO1, 2, 3) probed their function vivo. demonstrated that RSPO3 plays...
Autoantibodies and the immunoreceptors to which they bind can contribute pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Spleen Tyrosine Kinase (Syk) is a non-receptor tyrosine kinase with central role in immunoreceptor (FcR) signaling immune cell functionality. Syk inhibitors have activity antibody-dependent activation assays, preclinical models arthritis, progressed into clinical trials for RA other diseases. Here we describe characterization novel...
A novel formal (4 + 1) annulation between
Existing speaker verification (SV) systems mainly consist of a frontend deep embedding network pretrained for identification(SID) followed by backend finetuned to provide similarity measure. Despite their success, the performance may degrade remarkably due domain mismatch. In this paper, we present novel dual-branch prototypical masked autoencoder(DB-PMAE) based SRE framework. Specifically, teacher and student branches with siamese encoders are jointly learn patch-level features prototypes....
Abstract Optimized animal models and effective imaging techniques are exceedingly important to study cranial defects in bone loss due chronic inflammation. In this study, the assessment procedure on a zebrafish inflammation‐type skull model was monitored vivo with spectral‐domain optical coherence tomography (SD‐OCT), efficacy of etidronate disodium regeneration assessed. An acute defect injury established adult using stereotaxic craniotomy device. SD‐OCT performed immediately following...
Objective . To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods A total 2452 RA at Hospitals Shanghai between January 2009 and February 2011 were analyzed. Their demographic clinical characteristics compared those without infection, determined by logistic regression analysis. Results Multivariate analysis indicated gender (<mml:math...
In the title-page footnotes of article by Jiang et al in May 2014 issue Arthritis & Rheumatology (pages 1121–1132), institutional affiliations authors who were designated with number 2 byline shown incorrectly. The correct are as follows: Jian Yang, PhD, Peter M. Visscher, PhD: University Queensland, Queensland Diamantina Institute, Translational Research and Brain Brisbane, Australia; Gibran Hemani, Patrick Danoy, MD, Dana Willner, Catherine Cremin, BSc(Hons), Johanna Hadler, Dipl Ing,...