A5101885064- Pulmonary Hypertension Research and Treatments
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Medical Research and Treatments
- Congenital Heart Disease Studies
- Stroke Rehabilitation and Recovery
- Heart Failure Treatment and Management
- Tuberculosis Research and Epidemiology
- Acute Ischemic Stroke Management
- Spinal Fractures and Fixation Techniques
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Infectious Diseases and Tuberculosis
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Issues in Pregnancy
- Pharmacological Effects of Natural Compounds
- Cerebrovascular and Carotid Artery Diseases
- Pharmacological Effects and Toxicity Studies
- Pelvic floor disorders treatments
- Cellular transport and secretion
- Neurological Disease Mechanisms and Treatments
- Cardiac Valve Diseases and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
Zunyi Medical University
2018-2025
PLA Academy of Military Science
2023-2024
Hunter Medical Research Institute
2021-2024
Guangzhou University of Chinese Medicine
2013-2024
Yangtze University
2022-2024
Chinese PLA General Hospital
2021-2024
Air Force Medical University
2024
Anhui Medical University
2015-2024
Chaohu Hospital of Anhui Medical University
2024
Washington University in St. Louis
2019-2024
Tuberculosis (TB) remains a serious global public health problem in the present. TB also affects other sites (extrapulmonary tuberculosis, EPTB), and accounts for significant proportion of tuberculosis cases worldwide. In order to comprehensively understand epidemiology EBTB China, improve early diagnosis treatment, we conducted large-scale multi-center observational study assess demographic data prevalence common EPTB inpatients, further evaluate concurrent with Pulmonary (PTB) associations...
COVID-19 is complicated by acute lung injury, and death in some individuals. It caused SARS-CoV-2 that requires the ACE2 receptor serine proteases to enter AEC. We determined what factors are associated with expression particularly patients asthma COPD.
Pulmonary artery hypertension (PAH) is an intractable disease of the small PAs in which multiple pathogenic factors are involved. Statins known to mitigate endothelial injury and inhibit vascular remodeling inflammation, all play crucial roles pathogenesis PAH. We tested hypothesis that nanoparticle (NP)-mediated delivery pitavastatin into lungs can be a novel therapeutic approach for treatment Among marketed statins, was found have most potent effects on proliferation PA smooth muscle cells...
Background There is a growing amount of evidence suggesting that immunity and inflammation play an important role in the pathophysiology schizophrenia. In this study, we aimed to examine relationship between hematological inflammatory markers with symptom severity Han Chinese patients drug-free Methods This retrospective study was conducted at Chaohu Hospital Anhui Medical University data were extracted from electronic medical record system over 5-year period (May 2017 April 2022), including...
Background and Purpose- Cerebral edema (CED) develops in the hours to days after stroke; resulting increase brain volume may lead midline shift (MLS) neurological deterioration. The time course implications of formation are not well characterized across spectrum stroke. We analyzed displacement cerebrospinal fluid (ΔCSF) as a dynamic quantitative imaging biomarker formation. Methods- selected subjects enrolled stroke cohort study who presented within 6 onset had baseline ≥1 follow-up...
Probes capable of simultaneously detecting and differentiating biothiols is crucial yet challenging in optical chemical sensing. In this study, we design a multimodal probe, CL-NBD, through integrating chemiluminescence (high sensitivity signal-to-noise ratio), absorption (visual discrimination by the naked eye), fluorescence to distinguish various biothiol species. CL-NBD exhibits distinct signal response modes for hydrogen sulfide (H2S), cysteine/homocysteine (Cys/Hcy), glutathione. Upon...
The gut-brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and gastrointestinal system. Our study aimed to explore correlation between intestinal microbiota demyelinating diseases from bibliometric perspective, focusing on research since 2014. A comprehensive search was carried out Web of Science Core Collection (WoSCC) locate studies diseases, with focus publications 1 January 2014 29 March 2024. We visualized analyzed...
Background: Sleep disorders, such as insomnia, are pervasive and frequently comorbid with depression, significantly affecting the quality of life patients. Insomnia is characterized by difficulty initiating or maintaining sleep, which leads to impairment. Depression persistent sadness loss interest, it often features symptoms insomnia. Understanding their interaction will be done for treatment strategies concerning both disorders. Despite existence extensive studies on insomnia there a...
Background: Epilepsy, the world’s third most prevalent chronic brain disorder, significantly affects patients’ quality of life and increases economic burden on families society. Previous studies have demonstrated that FK506-binding protein 51 (FKBP51) plays a crucial role in synaptic plasticity. However, FKBP51 exhibits different functions under various physiological pathological conditions. Our study explored relationship between epilepsy its possible mechanism action. We also analyzed...
The erythropoietin-producing hepatoma (EPH) receptor A2 (EphA2) belongs to the Eph family of tyrosine kinases. EphA2 is highly correlated with formation many solid tumors and has been linked dysregulation signaling pathways that promote tumor cell proliferation, migration, invasion as well angiogenesis. Deregulation Wnt implicated in forms human disease including gastric cancer. We previously reported promotes epithelial-mesenchymal transition through Wnt/β-catenin Herein, we present a novel...
Abstract Cervical spondylosis (CS)-related neck pain is difficult to treat because of its degenerative nature. The aim this 9-center, single-blinded, randomized controlled trial was evaluate the efficacy optimized acupuncture for CS-related pain. Participants who met inclusion criteria were optimized, shallow, and sham groups (1:1:1). primary outcome change from baseline in Northwick Park Neck Pain Questionnaire score at week 4. followed up until 16. Of 896 participants, 857 received ≥1...
Abstract Background and Objective Severe asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non‐eosinophilic asthma. Non‐eosinophilic further divided into paucigranulocytic neutrophilic characterized by elevated neutrophils, mixed Type 1 17 cytokines in the airways. has few effective treatments many patients do not qualify for biologic therapies. The cystic fibrosis transmembrane conductance...
Anti-angiotherapy (Bevacizumab) is currently regarded as a promising option for glioma patients who are resistant to temozolomide (TMZ) treatment. But ongoing clinical research failed meet therapeutic expectations. This study aimed explore the pivotal genetic feature responsible TMZ and Bevacizumab resistance in patients.We downloaded transcriptomic methylation data of from The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), Gene Expression Omnibus (GEO) databases grouped these into...
Abstract Background Glioblastoma multiforme (GBM) is the most aggressive primary brain malignancy. Novel therapeutic modalities like tumor electric field therapy (TEFT) have shown promise, but underlying mechanisms remain unclear. The extracellular matrix (ECM) implicated in GBM progression, warranting investigation into TEFT‐ECM interplay. Methods T98G cells were treated with TEFT (200 kHz, 2.2 V/m) for 72 h. Collagen type VI alpha 1 (COL6A1) was identified as hub gene via comprehensive...
Insulin signaling can regulate various physiological functions, such as energy metabolism and reproduction so on, in many insects, including mosquito locust. However, the molecular mechanism of this process remains elusive. The tobacco cutworm, Spodoptera litura, is one most important pests agricultural crops around world. In study, phosphoinositide 3-kinase (SlPI3K), protein kinase B (SlAKT), target rapamycin (SlTOR), ribosomal S6 (SlS6K) transcription factor cAMP-response element binding...
People with diabetes are at high risk for shoulder pain, limited joint mobility, and adhesive capsulitis.The objective of this study was to evaluate the effects a movement intervention (ShoMo) compared wellness on primary outcomes active flexion reported Shoulder Pain Disability Index (SPADI) measured after 9 months later.The design prospective, randomized, controlled clinical trial.The setting research center an academic medical center.Fifty-two participants type 2 pain or motion were...
Objective: To investigate the clinicopathologic features and possible causes of granulomatous lobular mastitis(GLM). Methods: Three hundred cases GLM were collected from surgical specimens diagnosed at Longhua Hospital, Shanghai University Traditional Chinese Medicine January 2015 to November 2017. Morphologic reviewed using HE staining. A total 116 investigated by Gram The expression CD3, CD20, CD68, IgG, IgG4, CD38 CD138 was detected immunohistochemical Results: age patients 23 47 years...
Due to the significantly higher wind energy density in high-latitude sea areas compared other regions, construction of offshore farms is shifting towards these areas. However, areas, large amounts ice float on surface during winter, making loads a critical factor affecting structural safety turbines. For monopile flexible turbines, installing an ice-breaking cone near waterline effective measure withstand threat ice. To clarify resistance performance conical turbine foundations brash zones,...
Postpartum depression (PPD) presents a significant public health challenge. While PPD's impact extends from maternal to child development, cultural stigma and lack of awareness, particularly in developing countries, contribute its underestimation under diagnosed. This study investigated the non-biological associated factors for PPD Shenzhen city due unique socioeconomic landscape, where rapid urbanization migrant influx could uniquely mental health. By identifying local determinants,...
Abstract Inhaled nitric oxide (iNO) has been used for patients with increased pulmonary vascular resistance (PVR) shortly after Fontan operation, but repeat deterioration of PVR during or its withdrawal remains a major concern. Milrinone, phosphodiesterase type 3 (PDE3) inhibitor, can also reduce postoperative hypertension. We hypothesized that iNO, in conjunction milrinone, provide additive benefits hemodynamics and the occurrence iNO failure/rebound. Thirty‐one marked elevation...