A5102224620- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Mesenchymal stem cell research
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- MicroRNA in disease regulation
- RNA regulation and disease
- Pharmacological Effects and Toxicity Studies
- Cancer-related molecular mechanisms research
- Neonatal and fetal brain pathology
- Medicinal Plant Pharmacodynamics Research
- Cholinesterase and Neurodegenerative Diseases
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- interferon and immune responses
- Medicinal Plants and Neuroprotection
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- Proteoglycans and glycosaminoglycans research
- Autophagy in Disease and Therapy
- Healthcare professionals’ stress and burnout
- Biological and pharmacological studies of plants
- Corneal Surgery and Treatments
Zunyi Medical University
2016-2025
Weatherford College
2024
Affiliated Hospital of Guizhou Medical University
2019-2020
MEI Research (United States)
2019
Affiliated Hospital of Zunyi Medical College
2018
Abstract In recent years, biomarkers have been integrated into the diagnostic process and become increasingly indispensable for obtaining knowledge of neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) human reported to participate a variety activities. Here, single-cell RNA sequencing analysis PBMCs from 4 AD patients (2 early stage, 2 late stage) normal controls was performed explore differential cell subpopulations patients. A significant...
Purpose: We aimed to retrospectively analyze the clinical features, laboratory and imaging results, predictors of poor prognosis for patients with an initial diagnosis autoimmune encephalitis (AE) at Affiliated Hospital Zunyi Medical University. Methods: Fifty AE who were admitted our hospital from May 2014 2018 enrolled retrospectively. Clinical characteristics experimental test data, including neutrophil-to-lymphocyte ratio (NLR), collected medical records within 24 hours admission....
Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason Alzheimer's disease (AD) pathogenesis. Thus, inhibition Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development agent candidates by cultured neurons against cytotoxicity widely accepted efficient strategy explore drug for patients. Previously, we have revealed trilobatin (TLB), a small molecule monomer, derives from Lithocarpus polystachyus...
The gut-brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and gastrointestinal system. Our study aimed to explore correlation between intestinal microbiota demyelinating diseases from bibliometric perspective, focusing on research since 2014. A comprehensive search was carried out Web of Science Core Collection (WoSCC) locate studies diseases, with focus publications 1 January 2014 29 March 2024. We visualized analyzed...
ABSTRACT The lack of natural aging‐inducing Alzheimer's disease (AD) model presents a significant gap in the current preclinical research. Here, we identified unique cohort 10 naturally aging tree shrews (TSs) displaying distinct Alzheimer's‐like pathology (ALP) from population 324, thereby establishing novel that closely mirrors human AD progression. Using single‐nucleus RNA sequencing, generated comprehensive transcriptome atlas, revealing cellular diversity and gene expression changes...
Abstract Background Epilepsy is one of the common clinical disorders with comorbid anxiety and depression that severely affects their quality life increases suicidality, while screening for currently lacks objective identifiers. This study aimed to analyze characteristics electroencephalogram (EEG) power spectrum in patients epilepsy depression, utilizing resting EEG data. Methods Resting data were collected under standard conditions from two groups: ( n = 42) without comorbidities 45). was...
TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role Trabid in tumors including hepatocellular carcinoma (HCC) and underlying mechanisms controlling its activity remain poorly understood. Here, we report that is significantly downregulated HCC tumor samples cell lines compared with normal controls expression level negatively correlated pathological grading, recurrence, metastasis. The...
Osteoarthritis (OA) is one of the most common but refractory degenerative articular cartilage diseases. The emerging human amniotic mesenchymal cells (hAMSCs) have been identified a promising stem cell source in repair, and hyaluronic acid (HA) versatile regulator for transplantation. Herein, an effective straightforward intra-articular injection therapy using cocktail hAMSCs HA developed to treat knee OA rat model. injured remarkably regenerated very close level normal after 56 days...
Osteogenic inducers play central roles in effective stem cell-based treatment of bone defects/losses. However, the current routine osteogenic inducer is a cocktail comprising three components that must be improved due to low induction efficiency and side effects. Therefore, there an urgent need develop safer more osteoinducers. Herein, we demonstrated effect Ganoderal A (GD-A), tetracyclic triterpenoid compound from Ganoderma lucidum. GD-A showed no cytotoxicity toward human amniotic...
Currently, the treatment of Alzheimer's disease (AD) is still at stage symptomatic due to lack effective drugs. The research on miracle fruit seeds (MFSs) has focused lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. purpose this study was provide data resources a potential drug for An AD mouse model established treated with MFSs 1 month. Morris water maze test used assess learning memory function mice. Nissl staining demonstrate histopathological...
Seizures induce the release of excitatory amino acids (EAAs) from intracellular fluid to extracellular fluid, and released EAAs primarily comprise glutamic acid (Glu) asparaginic (Asp). Glu neurotransmission functions via EAA transporters (EAATs) maintain low concentrations in space avoid excitotoxicity. EAAT2, most abundant transporter subtype central nervous system (CNS), plays a key role regulation glutamate transmission. Previous studies have shown that SB203580 promotes EAAT2 expression...
CD44 antigen (CD44) is a transmembrane protein found in cell adhesion molecules and involved the regulation of various physiological processes cells. It was hypothesized that directly affected chondrogenic differentiation human amniotic mesenchymal stem cells (hAMSCs). In present study, expression chondrocyte‑associated factors detected absence presence antibody blocker anti‑CD44 during hAMSCs. Following inhibition expression, transcriptional levels genes SRY‑box transcription factor 9,...
This study aimed to explore the neuroprotective effect of icariin/icaritin (ICA/ICT) and role ICA/ICT in treatment Alzheimer's disease (AD). ICA ICT were used treat okadaic acid (OA)-induced Tau hyperphosphorylation SH-SY5Y cells. We detected relative changes Tau, p-Tau, protein phosphatase 2A (PP2A), glycogen synthase kinase 3β (GSK-3β) by Western blotting enzyme-linked immunosorbent assay. At 40 nmol/L OA, cell viability cells was significantly changed. different concentrations IC AD model...
Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in microenvironment adhesion of surrounding tissues can affect quality regeneration repair. Previous studies have shown that human amniotic membrane promote healing a variety tissues. In this study, right common peroneal underwent 5-mm transection rats. Epineural repair was performed using 10/0 non-absorbable surgical suture. The site wrapped with two-layer...
Human amniotic epithelial cells (hAECs) are a useful and noncontroversial source of stem for cell therapy regenerative medicine, but their limited proliferative ability hinders the acquisition adequate quantities clinical use due to not expressing telomerase in hAECs. Our previous study showed that hyaluronic acid (HA), an important component extracellular matrix, promoted proliferation human mesenchymal cells. Herein, we hypothesize HA might improve capability In present study, role on...