A5061612232- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Anomalies and Fetal Surgery
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Parasitic infections in humans and animals
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Immune Response and Inflammation
- Clinical Nutrition and Gastroenterology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- Metastasis and carcinoma case studies
Harbin Medical University
2011-2020
First Affiliated Hospital of Harbin Medical University
2011-2020
Fourth Affiliated Hospital of Harbin Medical University
2006
Harbin Institute of Technology
2006
The role of LncRNA ADAMTS9-AS2 in the regulation chemoresistance gastric cancer (GC) is largely unknown. Here we found that was low-expressed GC tissues and cells compared to their normal counterparts. In addition, inhibited miR-223-3p expressions by acting as competing endogenous RNA, levels showed negative correlations tissues. Of note, overexpression cell viability motility sponging miR-223-3p. were lower, higher cisplatin-resistant (CR-GC) than parental cisplatin-sensitive (CS-GC) cells....
UVRAG (UV radiation resistance associated) is an important regulator of mammalian macroautophagy/autophagy by interacting with BECN1, PIK3C3, and RUBCN. Phosphorylation MTORC1 negatively regulates autophagosome maturation under nutrient-enriched conditions. However, how ubiquitination regulated still unknown. Here we report that ubiquitinated SMURF1 at lysine residues 517 559, which decreases the association RUBCN promotes maturation. deubiquitinase ZRANB1 specifically cleaves SMURF1-induced...
Summary Inflammatory bowel disease (IBD)-associated thromboembolic event often lacks precise aetiology. The aim of this study was to investigate the contribution phosphatidylserine (PS) exposure and neutrophil extracellular traps (NETs) towards hypercoagulable state in IBD. We demonstrated that levels PS exposed MPs sources MP-origin, platelets, erythrocytes, leukocytes cultured endothelial cells (ECs) were higher IBD groups than healthy controls using flow cytometry confocal microscopy....
Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in hypercoagulable state colon patients remains unclear. We explored exposure PS on platelets and microparticles (MPs), evaluate its procoagulant activity patients. PS-positive MPs, mainly from endothelial cells, were detected flow cytometry confocal microscopy, their was assessed with purified complex assays, clotting time, fibrin turbidity. Plasma levels increased...
Abstract Altered expression of microRNA-590-5p (miR-590-5p) is involved in tumorigenesis, however, its role colorectal cancer (CRC) remains to be determined. In this study, we focused on examining the effects different levels miR-590-5p cells and normal cells. Results showed that there are lower human CRC tissues than control tissues. Similarly, our xenograft mouse model, knockdown promoted progression CRC. However, an overexpression mice inhibited angiogenesis, tumor growth, lung...
Cystic echinococcosis (CE) caused by the larval stage of Echinococcus granulosus sensu lato (s.l.) is one most important zoonotic parasitic diseases worldwide and 10 genotypes (G1–G10) have been reported. In China, almost all epidemiological genotyping studies E. s.l. are from west northwest pasturing areas. However, in Heilongjiang Province northeastern no molecular information available on To understand to speculate possible transmission patterns s.l., we molecularly identified genotyped...
TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role Trabid in tumors including hepatocellular carcinoma (HCC) and underlying mechanisms controlling its activity remain poorly understood. Here, we report that is significantly downregulated HCC tumor samples cell lines compared with normal controls expression level negatively correlated pathological grading, recurrence, metastasis. The...
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes. However, very little known about the regulatory mechanisms metabolism in hepatocellular carcinoma (HCC). We explored role dual‐specificity tyrosine (Y) phosphorylation–regulated kinase 3 (Dyrk3) HCC metabolism. Dyrk3 significantly down‐regulated compared with normal controls. Its...
Cyclovirobuxine D (CVB‑D) is an alkaloid, which mainly derived from Buxus microphylla. It has been reported that CVB‑D positive effects on breast cancer, gastric cancer and other malignant tumors. However, to the best of our knowledge, there are no reports regarding colorectal (CRC). The purpose present study was determine anticancer further elucidate its molecular mechanism(s). DLD‑1 LoVo cell lines were selected evaluate antitumor effect CVB‑D. Cytotoxicity, viability proliferation...
Despite considerable recent advancements in colorectal cancer (CRC) therapy, the prognosis of patients with advanced disease remains poor. Further understanding molecular mechanisms and treatment strategies this is required. Zinc finger protein 692 (ZNF692), also known as AREBP Zfp692, was first reported to have an important role gluconeogenesis. A study demonstrated that ZNF692 overexpressed lung adenocarcinoma (LUAD) tissues knockdown inhibited LUAD cell proliferation, migration, invasion...
Abstract The abnormal expression of adipocyte enhancer binding protein 1 (AEBP1) has been implicated in the carcinogenesis and progression various types human tumors. However, role AEBP1 colon adenocarcinoma (COAD) remains largely unelucidated. In this study, we explored clinical significance biological function COAD. We observed that was overexpressed COAD tissues cells correlated with tumor size, level histologic differentiation, lymph node metastasis, cancer stage patients. addition,...
Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western northwestern China considered as CE endemic areas. In northeastern China's Heilongjiang Province, increasing number sporadic human cases has attracted more attention. aims present study were to understand clinical characteristics investigated area compare coincidence rates CT, ultrasound serological test...
Abstract CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH) 2 D 3 concentration impacting on carcinogenesis. A case–control study including 528 colorectal cancer (CRC) patients 605 cancer-free controls a follow-up with 317 cases were conducted in northeast China. Genotypes tested by TaqMan Genotyping Assays. Individuals carrying the GG genotype of G > T (rs10877012) exhibited decreased CRC risk compared those TT (OR adjusted adj ) = 0.57, 95% Confidence Interval (CI) 0.38–0.84)....
Neuroblastoma is the most common extracranial solid tumor in childhood which often acquires drug resistance and becomes aggressive phenotypes. The high-risk patients suffer from high mortality due to limitation of treatment strategies. ARID1A (AT-rich interactive domain-containing protein 1A), a subunit SWI/SNF complexes, considered as suppressor many cancers. aim present study was investigate effect on migration invasion neuroblastoma cells. shRNA targeting designed delivered into SK-N-SH...
Fangchinoline (FAN), an alkaloid extracted from Stephania tetrandra, has a variety of biological and pharmacological activities, but evidence its effects on colon adenocarcinoma (COAD) is limited. Therefore, the present study aimed to elucidate molecular mechanisms by which FAN affects COAD. The cytotoxicity, viability proliferation DLD‑1 LoVo cells were assessed in presence using MTT colony formation assays. apoptosis cell cycle COAD analysed flow cytometry, migration invasion these wound...
Zinc finger protein 281 (ZNF281) has been recently shown to be critical for CRC progression. However, the immediate upstream regulators of ZNF281 remain unclear. Here we reported that E3 ligase β-transducin repeat-containing 2 (β-TrCP2) governs ubiquitination and degradation ZNF281. In human specimens, endogenous β-TrCP2 were inversely correlated with Beta-TrCP2 reversed phenotype cell overexpressed Moreover, found glycogen synthase kinase 3β (GSK-3β), not GSK-α, could bind phosphorylate at...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of gastrointestinal tract.Imatinib mesylate was considered a breakthrough drug in clinical treatment GIST, but GIST patients showed resistance to it.We aimed identify critical microRNAs (miRNAs) related imatinib imatinib-treated patients.Microarray datasets under accession numbers GSE63159 and GSE45901 were downloaded from Gene Expression Omnibus (GEO) database.The differentially expressed miRNAs (DEMs)...
Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation genome. With advances bioinformatics and genomics, extensive identification characterization lncRNAs is now possible. They regulate cellular growth, differentiation apoptosis. Dysregulation has been associated with numerous types human cancer. In present study, expression profile differentially expressed genes (DEGs) gastric cancer (GC) samples...
The objective of this study was to detect changes in T lymphocyte subpopulations mice with CT26 subcutaneous colon cancer after treatment donor infusion (DLI) and cyclophosphamide (CP) chemotherapy. A model established by injection carcinoma cells into BALB/C mice. were randomized different groups. We recorded survival times, tumor growth inhibition rates, histopathological changes, subsets peripheral blood the Mice treated DLI CP survived 33.5 ± 5.02 days, which significantly longer than...
AIM:To investigate the effect of donor splenocyte infusion combined with cyclosporine A (CsA) on rejection rat small bowel transplantation (SBT). METHODS:Male Sprague-Dawley (SD) rats and female Wistar weighing 230-270 g were used as donors recipients respectively in study.Heterotopic was performed.The divided into three groups: group one receiving allotransplantation (SD→Wistar), two (SD→Wistar) + infusion, (SD →Wistar) CsA followed by 10 mg/kg per day after transplantation, which recipient...