A5101639721- Xenotransplantation and immune response
- Animal Genetics and Reproduction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Spinal Fractures and Fixation Techniques
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- S100 Proteins and Annexins
- Pelvic and Acetabular Injuries
- Hippo pathway signaling and YAP/TAZ
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Urologic and reproductive health conditions
- Liver Disease and Transplantation
- Birth, Development, and Health
- HIV/AIDS Research and Interventions
- Fibroblast Growth Factor Research
- Acute Ischemic Stroke Management
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- HIV, Drug Use, Sexual Risk
- Allergic Rhinitis and Sensitization
Hainan Medical University
2020-2025
Beijing University of Chinese Medicine
2025
Shenyang Institute of Automation
2025
Zhejiang University of Science and Technology
2023-2024
University of South China
2017-2024
Peking University Third Hospital
2023-2024
Peking University
2014-2024
PLA 306 Hospital
2024
Shandong Provincial Hospital
2013-2024
Shandong First Medical University
2023-2024
Genetically engineered pigs could provide a source of kidneys for clinical transplantation. The two longest kidney graft survivals reported to date have been 136 and 310 days, but survival >30 days has unusual until recently.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The Yes-associated protein-1 (YAP) plays a critical role in cell proliferation, apoptosis and angiogenesis. Verteporfin photosensitizer used photodynamic therapy also small molecular inhibitor Hippo-YAP pathway. However, little known about whether verteporfin could inhibit YAP activity PDAC cells. Our present results showed that suppressed proliferation PANC-1 SW1990 cells by arresting at G1 phase,...
Despite the presence of neutrophil extracellular traps [NETs] in inflamed colon having been confirmed, role NETs, especially circulating progression and thrombotic tendency inflammatory bowel disease [IBD] remains elusive. We extended our previous study to prove that NETs constitute a central component prothrombotic state IBD.In all 48 consecutive patients with IBD were studied. Acute colitis was induced by treatment C57BL/6 mice 3.5% dextran sulphate sodium [DSS] drinking water for 6 days....
BackgroundThe role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) stroke patients caused by thromboembolic occlusion the internal carotid artery (ICA) remains unclear. Our objectives were to evaluate critical NETs induction hypercoagulability and identify functional significance during atherothrombosis.MethodsThe levels NETs, activated platelets (PLTs), PLT-derived microparticles (PMPs) detected plasma 55 35 healthy controls. NET formation thrombi analysed using...
Summary Inflammatory bowel disease (IBD)-associated thromboembolic event often lacks precise aetiology. The aim of this study was to investigate the contribution phosphatidylserine (PS) exposure and neutrophil extracellular traps (NETs) towards hypercoagulable state in IBD. We demonstrated that levels PS exposed MPs sources MP-origin, platelets, erythrocytes, leukocytes cultured endothelial cells (ECs) were higher IBD groups than healthy controls using flow cytometry confocal microscopy....
Sda, produced by the B4GALNT2 enzyme, has been recognized as an important xenoantigen for pig-to-nonhuman primate xenotransplantation. However, little is known about Sda expression in pigs and its immunogenicity In this study, peripheral blood mononuclear cells (PBMCs) were isolated from wildtype, GTKO (with high, moderate, low expression), GTKO/β4GalNT2KO, GTKO/CMAHKO, or GTKO/CMAHKO/β4GalNT2KO pigs. Anti-pig IgM/IgG binding complement-dependent cytotoxicity (CDC) to pig PBMCs was measured...
Gene-edited pigs for xenotransplantation usually contain one or more transgenes encoding human complement regulatory proteins (CRPs). Because of species differences, CRP(s) expressed in gene-edited may have difficulty inhibiting the activation exogenous rabbit added to a complement-dependent cytotoxicity (CDC) assay. The use instead CDC experiments accurately reflect actual activity CRP(s). Peripheral blood mononuclear cells (PBMCs) were obtained from GTKO pig and two GTKO/hCD55 with high...
BACKGROUND Precancerous lesions of gastric cancer (PLGC) represent a critical pathological stage in the development intestinal cancer. Early detection and diagnosis are key to reducing incidence Substantial advancements have been made PLGC research recent years, making it necessary provide updated reviews using bibliometric methods. We hypothesize that this review will identify emerging trends, areas, gaps research, providing insights could guide future studies enhance prevention strategies....
ABSTRACT Background Gene‐edited pigs for xenotransplantation usually contain one or more transgenes encoding human complement regulatory proteins (CRPs). Because of species differences, CRP(s) expressed in gene‐edited may have difficulty inhibiting the activation exogenous rabbit added to a complement‐dependent cytotoxicity (CDC) assay. The use instead CDC experiments accurately reflect actual activity CRP(s). Methods Peripheral blood mononuclear cells (PBMCs) were obtained from GTKO pig and...
Inflammation is known to preclude tolerance after transplantation. We have previously shown that systemic inflammation in xenograft recipients (SIXR) precedes activation of coagulation the absence T cell responses. Accordingly, SIXR may amplify innate and adaptive immune responses against xenografts pig-to-primate xenotransplantation, even with efficient immunosuppressive therapy. evaluated impact anti-inflammatory agents on pro-inflammatory cytokines chemokines pig artery patch heart...
Platelet‑derived growth factor (PDGF) is a potent mitogen and chemoattractant that serves role in the development of several types solid cancer, abnormal PDGF activity has been reported numerous human tumors. Tumor‑derived ligands are considered to act either paracrine or autocrine manner, serving roles phosphorylation receptors on tumor stromal cells microenvironment. Despite well‑established association between progression, precise mechanisms signaling pancreatic remain elusive. Therefore,...
Hepatic ischemia/reperfusion (I/R) injury is a common clinical problem. The present study was conducted to investigate the protective effect and mechanism of minocycline (Mino), tetracycline with anti-inflammatory antioxidant properties, on I/R liver in rats. In total, 54 male Sprague-Dawley rats were randomly divided into 3 groups 18 each: Sham-operated (control group), model (I/R group) Mino preconditioning (Mino group). group administered (45 mg/kg) by gastric irrigation at 36 h before...
This study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), D-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with disease activity. Data from 105 RA patients 102 age- gender-matched healthy controls were collected retrospective study. Disease activity score 28 joints based on C-reactive protein (DAS28-CRP) was used divide into low group (DAS28-CRP ≤ 2.7) active > 2.7). Receiver operating characteristic (ROC) curve...
Background: Platelet (PLT) and red blood cell (RBC) have been demonstrated to play a critical role in inflammatory processes. This study aimed evaluate the association of PLT RBC related parameters with disease activity rheumatoid arthritis (RA) patients, also investigate these indices differentiating among RA patients different activity. Methods: Clinical data from were retrospectively analyzed. divided into inactive group active according DAS28-CRP. The relationship between counts-related...
Background Severe coronavirus disease 2019 (COVID -19) has led to severe pneumonia or acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill patients with COVID-19 present typical sepsis-related clinical manifestations, including multiple organ dysfunction syndrome, coagulopathy, and septic shock. The molecular mechanisms underlie COVID-19, ARDS sepsis are not well understood. objectives of this study were analyze potential identify drugs for the...
In Brief Background Serum (extracellular) histone levels are increased in inflammatory states and the presence of coagulation dysfunction, for example, trauma, chemical/ischemic injury, infection. There is increasing evidence a systemic response associated with pig xenograft nonhuman primate. We evaluated extracellular baboons various xenografts. Methods measured serum histones heterotopic heart (n = 8), life-supporting kidney 5), orthotopic liver 4), artery patch 9) grafts by enzyme-linked...
Although colorectal cancer (CRC) is a prevalent malignancy of the digestive system, underlying mechanisms CRC tumorigenesis are still elusive. Arrestin-related domain-containing protein-3 (ARRDC3) has been reported to promote lysosome-mediated protein degradation. In present study, we find that expression ARRDC3 downregulated in specimens. Mechanistically, reveal binds and decreases oncoprotein YAP, cotranscription factor Hippo pathway. The regulation pathway by conserved from Drosophila...
Background Malva sylvestris L. (commonly known as mallow) has been widely used in traditional Tibetan formulations to treat allergic rhinitis (AR), and malvidin is a key anti-inflammation constituent of this plant. Objective The present study aimed evaluate the potential therapeutic effect mechanism an AR mouse model. Methods Malvidin's efficacy was evaluated model induced by ovalbumin (OVA) sensitization challenge. factors, such nasal symptoms, serum OVA-specific immunoglobulin E (IgE)...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is subdivided into type 1 and 2 inflammatory responses according to the mucosal patterns. Crocin can reduce level of T-helper cell (Th2) cytokines, such as interleukin-4 (IL-4), inhibit nuclear factor kappa-B (NF-κB) signaling pathway. Objective This study aimed investigate role group innate lymphoid cells (ILC2s) in inflammation eosinophilic inhibitory effect crocin on this inflammation. Methods Immunohistochemistry...
Purpose: Abnormal growth of vertebral body plate (VBGP) is considered as one the etiologic factors in adolescent idiopathic scoliosis (AIS).It was well-known that melatonin correlated with emergence and development AIS.This study aimed to investigate effect on rat VBGP chondrocytes vitro.Methods: Chondrocytes were isolated from VBGP, treated or without melatonin.Cell proliferation measured by Alamar Blue assay.Gene expression collagen type II aggrecan evaluated real-time PCR.Expression...